| Identification |
|---|
| BMDB Protein ID
| BMDBP01246 |
| Secondary Accession Numbers
| |
| Name
| Glucose-6-phosphate isomerase |
| Synonyms
|
Not Available
|
| Gene Name
| GPI |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). |
| Pathways
|
- Carbohydrate degradation
- D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4
- Glycolysis
|
| Reactions
|
| Fructose 6-phosphate → Glucose 6-phosphate |
details
|
| Beta-D-Glucose 6-phosphate → Fructose 6-phosphate |
details
|
| Beta-D-Glucose 6-phosphate → Glucose 6-phosphate |
details
|
| Beta-D-Fructose 6-phosphate → Glucose 6-phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q22-q24 |
| SNPs
| GPI |
| Gene Sequence
|
>1674 bp
ATGGCCGCGCTCACCCAGAACCCGCAGTTCAAGAAACTGAAGACATGGTACGAGCAGCAC
GGCTCTGACCTCAACTTGCGCCGCCTTTTCGAAGGAGACAGGGACCGCTTTAACCGCTTC
AGCTTGAACCTCAACACCAACCATGGGCATATTCTGGTGGACTACTCCAAGAACCTGGTG
ACGGAGACTGTGATGCAGATGCTGGTGGACGTGGCTAAGTCCAGGGGTGTGGAGGCCGCC
CGGGAGCGCATGTTTACTGGTGAGAAGATCAACTTCACTGAGGATCGGGCTGTGCTGCAC
GTGGCCCTTCGGAACCGATCAAACGCACCCATTTTGGTGGATGGTAAGGATGTGATGCCA
GAGGTCAACAGAGTCCTGGAGAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGTGGTGAA
TGGAAAGGGTACTCGGGCAAGGCCATCACGGACGTCATCAACATCGGTATTGGCGGCTCT
GACCTGGGACCCCTCATGGTGACTGAATCCCTCAAGCCCTACTCTTCAGAAGGTCCCCGG
GTCTGGTTTGTCTCCAACATTGACGGGACTCACATTGCCAAAACGCTGGCCACCCTGAAC
CCCGAGTCCTCTCTCTTTATCATTGCCTCCAAGACCTTCACTACCCAGGAGACCATCACG
AACGCAGAGACAGCGAAGGAGTGGTTTCTCCTGTCGGCCAAGGATCCTTCTGCAGTCGCG
AAACACTTTGTTGCCCTGTCTACCAACACTGCCAAAGTGAAGGAGTTTGGAATTGATCCT
CAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGCCGCTACTCGCTGTGGTCAGCCATC
GGACTCTCCATTGCCCTGCACGTGGGATTTGACAACTTCGAGCAGCTGCTCTCAGGAGCT
CACTGGATGGACCAGCACTTCCGCACAACGCCCCTGGAGAAGAACGCCCCCGTGCTGCTG
GCTCTGCTGGGCATATGGTACATCAACTGCTTTGGGTGTGAGACGCACGCCATGCTGCCC
TATGATCAGTACCTGCACCGCTTTGCTGCCTACTTCCAGCAGGGTGACATGGAGTCCAAT
GGGAAGTACATCACCAAGTCTGGCACCCGCGTGAACTACCAGACGGGCCCCATTGTGTGG
GGGGAGCCAGGGACCAATGGCCAGCACGCCTTCTACCAGCTCATCCACCAAGGTACCAAG
ATGATACCCTGCGACTTCCTCATCCCGGTCCAGAGCCAGCACCCCATAAGGAACGGTTTG
CATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACTGAGGCCCTGATGAGGGGGAAG
TCGACAGAGGAGGCCCGGAAGGAGCTACAGGCTGCTGGAAGGAGTCCAGAGGACTTTGAG
AAGCTGTTGCCTCACAAGGTCTTTGAAGGAAATCGCCCGACCAACTCTATAGTGTTCACC
AAACTCACGCCATTCATTCTTGGAGCCTTGATTGCCATGTATGAGCACAAGATCTTCGTT
CAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAG
CTGGCTAAGAAAATTGAACCTGAGCTTGACGGGAGCAGCCCAGTGACTTCTCACGATTCT
TCCACCAATGGGCTGATCAACTTCATCAAGCAGGAGCGAGAGGCCAGAAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 557 |
| Molecular Weight
| 62855.0 |
| Theoretical pI
| 7.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glucose-6-phosphate isomerase
MAALTQNPQFKKLKTWYEQHGSDLNLRRLFEGDRDRFNRFSLNLNTNHGHILVDYSKNLV
TETVMQMLVDVAKSRGVEAARERMFTGEKINFTEDRAVLHVALRNRSNAPILVDGKDVMP
EVNRVLEKMKSFCQRVRSGEWKGYSGKAITDVINIGIGGSDLGPLMVTESLKPYSSEGPR
VWFVSNIDGTHIAKTLATLNPESSLFIIASKTFTTQETITNAETAKEWFLLSAKDPSAVA
KHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA
HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVNYQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQSQHPIRNGL
HHKILLANFLAQTEALMRGKSTEEARKELQAAGRSPEDFEKLLPHKVFEGNRPTNSIVFT
KLTPFILGALIAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDS
STNGLINFIKQEREARS
|
| External Links |
|---|
| GenBank ID Protein
| AAI03417.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBD7 |
| UniProtKB/Swiss-Prot Entry Name
| G6PI_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DAAA02046903 |
| GeneCard ID
| GPI |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
