| Identification |
|---|
| BMDB Protein ID
| BMDBP01276 |
| Secondary Accession Numbers
| None |
| Name
| Glutathione S-transferase A1 |
| Synonyms
|
Not Available
|
| Gene Name
| GSTA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| GSTA1 |
| Gene Sequence
|
>669 bp
ATGGCAGGGAAGCCCACTCTTCACTATTTCAATGGACGCGGCAGAATGGAGTGCATTCGG
TGGCTCCTAGCTGCAGCTGGAGTGGAGTTTGAAGAGAAATTTATAGAAAAACCAGAAGAC
TTGGATAAGTTAAAAAATGATGGGAGTTTGATGTTCCAGCAAGTGCCAATGGTTGAAATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCACCAAATACAAC
CTCTACGGGAAAGACATGAAGGAGAGAGCCCTGATTGATATGTATTCAGAGGGTGTGGCA
GATTTGGGTGAAATGATCATGCATTTTCCACTGTGCCCACCTGCTGAAAAAGATGCCAAG
CTGACCCTAATCCGAGAAAAGACAACAAACCGTTATCTCCCTGCATTTGAAAATGTGCTG
AAGAGCCATGGACAAGACTACCTGGTGGGCAACAAGCTGAGCAGGGCTGACATCCACTTG
GTTGAACTTCTCTACTATGTGGAAGAGCTGGACCCCAGCCTTTTGGCCAACTTCCCTCTG
CTAAAGGCCCTAAAAGCCAGAGTCAGCAGTCTCCCGGCTGTGAAGAAATTTCTGCAGCCT
GGCAGCCAGAGGAAGCCTCCCACGGATGAGAAAAAAATAGAAGAAGCCAGGAAGGTTTTC
AAGTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 222 |
| Molecular Weight
| 25452.0 |
| Theoretical pI
| 8.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione S-transferase A1
MAGKPTLHYFNGRGRMECIRWLLAAAGVEFEEKFIEKPEDLDKLKNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYSEGVADLGEMIMHFPLCPPAEKDAK
LTLIREKTTNRYLPAFENVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDPSLLANFPL
LKALKARVSNIPAVKKFLQPGSQRKPPTDEKKIEEARKVFKF
|
| External Links |
|---|
| GenBank ID Protein
| AAB72239.1 |
| UniProtKB/Swiss-Prot ID
| Q28035 |
| UniProtKB/Swiss-Prot Entry Name
| GSTA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U49179 |
| GeneCard ID
| GSTA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
