| Identification |
|---|
| BMDB Protein ID
| BMDBP01279 |
| Secondary Accession Numbers
| None |
| Name
| Monoacylglycerol lipase ABHD6 |
| Synonyms
|
Not Available
|
| Gene Name
| ABHD6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acylglycerol lipase activity |
| Specific Function
| Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| ABHD6 |
| Gene Sequence
|
>1014 bp
ATGGATCTTGACGTGGTTAACATGTTTGTGATTGCGGGTGGGACACTGGCCCTTCCGATC
CTGGCATTCGTAGCCTCTTTTCTCCTGTGGCCTTCAGCCCTGATAAGAATCTATTACTGG
TACTGGCGGAGGACGCTGGGCATGCAGGTCCGCTATGTGCGCCACGAAGACTATCAGTTC
TGCTACTCCTTCCGTGGCAGGCCTGGCCACAAACCTTCCATCCTCATGCTCCACGGGTTC
TCTGCCCACAAGGACATGTGGCTCAGCATGGTCAAGTTCCTCCCGAAGAACCTGCACCTG
GTCTGCGTGGACATGCCAGGGCATGAAGGCACCACTCGGTCCTCACTGGATGACCTGTCC
ATAGATGGGCAAGTCAAGAGGATACACCAGTTTGTAGAATGCCTCAAGCTGAACAAAAAG
CCCTTCCACCTGGTAGGCACCTCCATGGGCGGCCACGTGGCTGGGGTGTATGCTGCTCAC
TACCCATCAGACGTCTGCAGCCTGTCCCTTGTGTGTCCTGCGGGTCTGCAGTACTCAACT
GATAATAAATTTGTGCAACGGCTCAAAGAACTGCAGGAGTCGGCCGCCGTAGAGAAGATT
CCCTTGATCCCGACCACCCCGAAGGAGATGAGTGAGATGCTGCAGCTCTGCTCCTACGTA
CGCTTCAAGGTGCCCCAGCAGATCCTGCAGGGCCTTGTTGATGTCCGCATCCCTCACAAC
ACCTTCTACCGAAAGCTGTTTTTGGAAATCGTCAGTGAGAAGTCGAGATACTCCCTCCAT
CAGAACATGGACAAGATTAAGGTCCCCACGCAGATCATCTGGGGGAAACAAGACCAGGTG
CTCGATGTGTCCGGGGCAGACATGTTGGCCAAGTCAATCGCCAACTCCCAGGTGGAGCTC
CTGGAAAACTGTGGGCACTCAGTGGTGATGGAGAGGCCCAGGAAGACAGCCAAGCTCCTT
GTCGACTTCTTGGCTTCTGTACACAGCACAGACAACAGCAAGAAGCTGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 337 |
| Molecular Weight
| 38353.0 |
| Theoretical pI
| 9.12 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Monoacylglycerol lipase ABHD6
MDLDVVNMFVIAGGTLALPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVRHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSMVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGHVAGVYAAHYPSDVCSLSLVCPAGLQYST
DNKFVQRLKELQESAAVEKIPLIPTTPKEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
TFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANSQVEL
LENCGHSVVMERPRKTAKLLVDFLASVHSTDNSKKLD
|
| External Links |
|---|
| GenBank ID Protein
| AAI16145.1 |
| UniProtKB/Swiss-Prot ID
| Q1LZ86 |
| UniProtKB/Swiss-Prot Entry Name
| ABHD6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC116144 |
| GeneCard ID
| ABHD6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
