| Identification |
|---|
| BMDB Protein ID
| BMDBP01285 |
| Secondary Accession Numbers
| None |
| Name
| Dehydrogenase/reductase SDR family member 11 |
| Synonyms
|
Not Available
|
| Gene Name
| DHRS11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. |
| Pathways
|
- Estrogen biosynthesis
- Steroid Biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| DHRS11 |
| Gene Sequence
|
>768 bp
ATGGAGCGGTGGCGTGACCGGCTGGCACTGGTGACGGGAGCCTCGGGAGGTATCGGCGCG
GCCGTGGCCCGGGCCCTGGTCCAGCAGGGTCTGAAGGTGGTGGGTTGTGCCCGCACCGTG
GGCAACATCGAGGAGCTGGCTGCCGAATGTAAGAGTGCAGGCTACCCCGGGACTTTGATC
CCCTACAGATGTGACCTGTCGAACGAGGAGGACATCCTCTCCATGTTCTCAGCGGTCCGC
TCTCAGCACAGCGGTGTGGACATCTGCATCAACAATGCTGGCCTGGCCCGGCCGGACACC
CTGCTCTCAGGCAGCACCAGCGGCTGGAAGGAAATGTTCAATGTGAACGTGCTGGCCCTC
AGCATCTGCACGCGGGAAGCCTGCCAGTCCATGAGGGAGCGGAAGGTGGATGACGGGCAC
ATCATCAACATCAACAGCATGTGTGGCCACCGAGTGCCACCCCCGGCTGAGACCCATTTC
TACAGTGCTACCAAGTACGCTGTCACCGCGCTGACGGAGGGGCTGAGGCAAGAGCTCCGG
GAGGCCCGGAGCCACATCCGAGCCACGTGCATTTCTCCAGGAGTGGTGGAGACACAGTTC
GCCTTCAAACTCCACGACAAGGACCCCGAGAAGGCAGCCGCCACCTATGAACACATGAAG
TGTCTCAAACCTGAGGATGTGGCCGAGGCCGTGATCTATGTTCTCAGCACGCCCCCTCAT
GTCCAGATCGGAGACATCCAGATGAGGCCCACAGAGCAGGTGACCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 255 |
| Molecular Weight
| 27811.0 |
| Theoretical pI
| 6.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dehydrogenase/reductase SDR family member 11
MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLI
PYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGLARPDTLLSGSTSGWKEMFNVNVLAL
SICTREACQSMRERKVDDGHIININSMCGHRVPPPAETHFYSATKYAVTALTEGLRQELR
EARSHIRATCISPGVVETQFAFKLHDKDPEKAAATYEHMKCLKPEDVAEAVIYVLSTPPH
VQIGDIQMRPTEQVT
|
| External Links |
|---|
| GenBank ID Protein
| AAI03082.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBV9 |
| UniProtKB/Swiss-Prot Entry Name
| DHR11_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC103081 |
| GeneCard ID
| DHRS11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
