1.0 2018-05-07 22:26:18 UTC 2020-05-20 21:12:04 UTC BMDBP01291 Enzyme MRVI1 Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. BMDB0004246 Bradykinin 15 >2736 bp ATGGTAAAAGCTCCCCAGAGTGAAGAGAGGCTGGCCGGAGGAGGAAAGGGGAATAACTCA GTTTTAGCCTGTGGAGCCCAGGCCTCTTGGAGCATCTTTGGGGCTGACGCAGCGGAGGTT CCGGGCACACGCAGTCACTCCCGCCAGGAGGCTGCCATGCCCCACATTCCCGAGGACGAG GAGCCCCCCGGAGAGCCACAGGCAGCCCAGAGCCCGGCCGGCCAAGACCCTGCCACCACA GGAATATCTTGCAGTCCACCCACCATCATCCTGACTGGGGATGCCAGTTCACCAGAAGGA GAAACTGACAAAAACCCGGTCAACAGAGCCCACAGTCCCCACAGGAGGCTTTCTCACCGA CACTTGAAGGTTTCCACTGCTTCGCTGACTTCTGTGGACCCTGCAGGGCACGTCATTGAC CTGGTCAATGACCAGCTGCCAGACATCAGCATCTCAGAGGAGGACAAGAAGAAAAACCTG GCACTACTGGAGGAAGCCAAGTTGGTGAGCGAGCGGTTCCTGACCCGCCGTGGAAGGAAG TCCAGGAGCAGTCCCGGAGAGTCCTCACCAGCTGTTTCCCCAAACCTCAGCCCCGGAGCT TCTCCTGCGTCCTCTCAGAGCAACTCCCTCACCGTCCCCACGCCGCCTGGTTTGGATGTG TGCAGTGGCCCACCGTCCCCTCTGCCCGGAGCACCGCCACAGAAGGGGGATGAGGCCGAA GTCCCTTCACCTCACCTTGGCGAGTCTAACGTCCTCAAAGGGCTAGCTGACCGGAAGCAG AATGACCAGAGAACACTGTCTCAGGGCAGGCTGACTGCCCGCTCTCCCACAGTTGAGAAG TCCAAAGAGATTACGATAGAACAAAAGGAAAACTTCGATCCCCTCCAGCGCCCGGAGGCC ATACCCAAGGGCCCAGCTTCTGGCCCAGGCAGTGGTGGGAAGATGGCCCTTAACAGCCCC CAGCCTGGCCCCGTGGAGAGCGAGCTGGGAAAGCCGCTGGCAAAGACAGCCAAGGAGGGC AACCCTCTGCCCAGAGGTCCAACCCAGGGCTCTGGGGGGGTGGCTCCCCAGGCCTCCCAG GGGAAGAGTACAGTTGGAGAGCCCGCAGGGTCCAAGGTTGGCTCCAAAGCTGAGCTGTGG CCCCCGACGTCCCGGCCGCCCCTGCTGCGGGGAGTGTCCTGGGACAGCGGCCCCGAAGAA CCCGGCCCCCGGCTGCAGAAAGTGCTTGCCAAGCTGCCGCTGGCTGAGGAAGAGAAGCGT TTTACAGGCAAAGCTGGCAGCAAGCTGGCCAAGGCGCCCGGACTCAAAGACTTTCAGATA CAAGTGCAGCCTGTGCGGATGCAGAAACTGACCAAGCTTCGTGAGGAGCACATCCTGCTG AGAAATCAGAACTTAGTGGGGCTCAAGCTTCCAGAACTTAGTGAAGCGGCTGAGCAGGAA AAAGGACACCCTTCTGAACTCTCCTCAGCTATTGAGGAAGAAGAGTCAAAGGGCGGGCTG GATGTCATGCCCAATATTTCTGATGTGCTGCTTCGCAAACTGCGGGTCCACAAGTCCCTC CCTGGAAGTGCCCCTCCACTCACTGAAAAGGAAGTCGAGAACGTGTTTGTACAACTGTCC TTGGCCTTTAGAAATGACAGCTACACCCTGGAATCTAGAATTAACCAGGCAGAAAGGGAA CGCAACCTGACAGAGGAAAACACAGAGAAGGAACTGGAAAACTTCAAAGCTTCCATTACG TCCTCAGCTTCCCTCTGGCACCACTGTGAGCACCGGGAGACCTACCAGAAGCTGCTGGAG GACATTGCTGTCCTGCACCGCCTGGCTGCCCGCCTCTCCAGCCGTGCCGAGATGGTGGGG GCCGTCCGCCAGGAAAAACGCATGTCGAAAGCAACAGAAGTGATGATGCAGTATGTGGAG AACCTAAAGAGGACGTATGAGAAGGACCATGCAGAGCTCATGGAGTTTAAAAAACTTGCA AATCAAAATTCGAGCCGCAGCTGTGGCCCCTCTGAAGATGGAGTCCCTCGCACAGCGCGG TCCATGTCCCTTTCGCTGGGAAAGAACATGCCCCGCCGAAGGGTCAGCGTTGCCGTGGTG CCCAAGTTTAATATCCTGAACCTGCCGGGCCAGTCACCCAGCTCATCCCCCATTCCTTCC TTACCAGCCCTGTCAGAATCATCCAATGGGAAAGGCAACCCACCTGTCTCCTCAGCACTG CCTGCACTTTTGGAAAATGGAAAGACAAATGGCGACCCAGATTGTGAAGCCTCTGCTTCT GTGCCAACTCCGAGCTGCCTGGAGGGGATCAGCCAGGAGGCTAAGGCCAGGATGGAGGAA GAAGCTTACAACAAGGGATACCAAGAAGGTCTAAAGAAAACCAAGGAGCTTCAAGGCCTG AGGGAGGAGGAAGAAGAACAGAAGAGCGAGAGCCCAGAGGAGCCAGAGGAGGTGGCAGAA ACTGAGGAAGAGGAGAAGGAGCAGAGAAGCAGCAAACTTGAAGAACTGGTTCATTTCTTA CAAGTCATGTATCCCAAACTGTGTCAGCATTGGCAAGTCATCTGGATGATGGCCGCGGCG ATGCTGGTCTTGACTGTCGTGCTGGGGCTCTACGGTTCCCATAACTCTTGCGTAGAGCAG GCCGACGGGTCCCTTGGGAAATCCACGTGCTCAGCAGCCCAACGGGACTCCTGGTGGAGC TCAGGACTCCAGCATGAGCAGCCTACAGAGCAGTAG 911 98375.0 6.05 853-873 None >Protein MRVI1 MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDE EPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHR HLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRK SRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQKGDEAE VPSPHLGESNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEQKENFDPLQRPEA IPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQ GKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKR FTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQE KGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLS LAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLE DIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLA NQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPS LPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEE EAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEVAETEEEEKEQRSSKLEELVHFL QVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWS SGLQHEQPTEQ AAF61202.1 Q9N1F0 MRVI1_BOVIN AF195526 MRVI1