| Identification |
|---|
| BMDB Protein ID
| BMDBP01293 |
| Secondary Accession Numbers
| |
| Name
| Adenosylhomocysteinase |
| Synonyms
|
Not Available
|
| Gene Name
| AHCY |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. |
| Pathways
|
- Amino-acid biosynthesis
- L-homocysteine biosynthesis
- L-homocysteine from S-adenosyl-L-homocysteine: step 1/1
|
| Reactions
|
| Se-Adenosylselenohomocysteine + Water → Selenohomocysteine + Adenosine |
details
|
| S-Adenosylhomocysteine + Water → Homocysteine + Adenosine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| AHCY |
| Gene Sequence
|
>1299 bp
ATGTCGGACAAGCTGCCTTACAAAGTCGCTGACATCAGCCTGGCCGCTTGGGGACGCAAG
GCCCTGGACCTGGCAGAGAATGAGATGCCGGGCCTGATGCACATGCGAGAAATGTACTCG
GCCTCCAAGCCTCTGAAGGGCGCTCGCATTGCTGGCTGCCTGCACATGACCGTGGAGACC
GCCGTCCTCATTGAGACCCTCGTTGCCCTGGGTGCTGAGGTGCGGTGGTCCAGCTGCAAT
ATCTTCTCCACCCAGGACCATGCAGCAGCTGCCATTGCCAAGGCTGGCATTCCAGTGTAC
GCCTGGAAGGGTGAAACGGATGAGGAGTACCTGTGGTGCATTGAACAGACGCTGTACTTC
AAGGACGGGCCCCTCAACATGATTCTGGACGACGGTGGTGACCTCACCAACCTCATCCAC
ACCAAGTACCCGCAGCTCCTGTCAGGCATCCGAGGCATCTCTGAAGAGACCACAACGGGG
GTCCACAACCTGTACAAGATGATGGCCAAAGGGATCCTGAAGGTGCCGGCCATCAATGTC
AATGACTCTGTCACCAAGAGCAAGTTTGACAACCTCTATGGCTGCCGGGAGTCCCTCATA
GATGGCATCAAGCGGGCCACAGATGTCATGATTGCGGGCAAGGTGGCGGTGGTTGCAGGC
TATGGCGACGTGGGCAAGGGCTGTGCCCAGGCCCTGAGGGGATTTGGGGCCCGCGTCATC
ATCACGGAGATTGACCCCATCAACGCACTTCAAGCTGCCATGGAGGGCTACGAGGTGACC
ACCATGGATGAGGCCTGTCAGGAGGGCAACATCTTTGTCACCACCACGGGCTGTACTGAC
ATCATTCTTGGCCAGCACTTTGAACAGATGAAGGATGATGCCATTGTGTGTAACATTGGG
CACTTTGACGTGGAGATCGATGTCAAGTGGCTGAACGAGAACGCTGTGGAGAAGGTGAAC
ATCAAGCCCCAGGTGGATCGCTACTTGTTGAAGAACGGACGCCGCATCATCCTGCTGGCC
GAGGGCCGGCTGGTCAACCTGGGCTGTGCCATGGGCCATCCTAGCTTTGTGATGAGCAAC
TCCTTCACCAACCAGGTCCTGGCGCAGATCGAGCTCTGGACCCACCCAGACAAGTACCCC
GTCGGAGTCCACTTCCTGCCCAAGAAGCTGGATGAAGCAGTGGCTGAAGCCCACCTGGGC
AAGCTGAATGTGAAGCTGACCAAGCTGACTGAGAAGCAGGCCCAGTACCTGGGCGTGTCC
CGTGAAGGCCCGTTCAAGCCTGATCACTACCGCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 432 |
| Molecular Weight
| 47638.0 |
| Theoretical pI
| 6.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenosylhomocysteinase
MSDKLPYKVADISLAAWGRKALDLAENEMPGLMHMREMYSASKPLKGARIAGCLHMTVET
AVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMAKGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCTDIILGQHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVLAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGVS
REGPFKPDHYRY
|
| External Links |
|---|
| GenBank ID Protein
| ABQ12977.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHL4 |
| UniProtKB/Swiss-Prot Entry Name
| SAHH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT030537 |
| GeneCard ID
| AHCY |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
