1.0 2018-05-07 22:26:23 UTC 2020-05-20 21:07:42 UTC BMDBP01309 Enzyme FURIN Posttranslational modification, protein turnover, chaperones Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). BMDB0000464 Calcium 21 >2394 bp ATGGAGCTGAGGCCCTGGTTGTTCTGGGTGGTAGCAGCAGCGGGAGCCTTGGTCCTGCTG GTGGCCGATGCCCGCGGAGAGAAGGTCTTCACCAACACCTGGGCCGTGCACATTCCTGGA GGCCCAGCCGTCGCTGACCGTGTGGCACGCAAGCATGGCTTCCTCAACCTGGGCCAGATC TTCGGTGACTATTACCACTTCTGGCATCGAGCGGTGACAAAGCGGTCCCTGTCTCCTCAC CGCCTGGGCCACAACCGGCTGCAGCGGGAACCTCAAGTTAAGTGGCTGGAGCAGCAGGTG GCAAAGCGACGGGCCAAACGGGACATATACCAGGAGCCCACGGACCCCAAGTTTCCCCAG CAGTGGTACCTGTCTGGCGTCACCCAGCGGGACCTGAATGTGAAGGAGGCCTGGGCGCAG GGCTACACGGGGCGTGGCATTGTGGTCTCTATCCTGGACGACGGCATCGAGAAGAACCAC CCAGACTTGGCAGGCAATTATGATCCTGGGGCCAGCTTCGATGTCAATGATCAGGACCCT GACCCCCAGCCCCGGTACACACAGATGAATGACAACAGGCATGGCACACGGTGTGCAGGA GAGGTGGCTGCGGTGGCCAACAATGGTGTCTGTGGCGTAGGCGTGGCCTACAATGCCCGA ATTGGAGGGGTGCGCATGCTGGATGGCGAAGTGACAGATGCCGTGGAGGCACGCTCGCTG GGCCTGAACCCCAACCACATCCACATCTACAGTGCCAGCTGGGGCCCCGAGGACGACGGC AAGACCGTGGATGGGCCAGCCCACCTGGCTGAGGAGGCCTTCTTCCGGGGGGTCAGCCAG GGCCGCGGGGGTCTGGGCTCCATCTTTGTCTGGGCCTCGGGGAACGGGGGCCGGGAACAT GACAGCTGCAATTGCGACGGCTACACCAACAGCATCTACACGCTGTCCATCAGCAGCGCC ACACAGTTCGGCAACGTGCCCTGGTACAGTGAGGCCTGCTCGTCCACGCTGGCCACCACC TACAGTAGTGGCAACCAGAATGAGAAGCAGATCGTGACCACTGACCTGCGGCAGAAGTGT ACAGAGTCTCACACGGGCACCTCTGCGTTCGCCCCACTGGCAGCAGGCATCATCGCTCTC ACCCTGGAGGCCAATAAGAACCTCACTTGGCGGGACATGCAGCACTTGGTAGTCCGGACC TCAAAGCCAGCCCACCTCAACGCCAACGACTGGGCCACCAATGGTGTGGGCCGCAAAGTG AGCCATTCGTACGGCTACGGGCTGTTGGACGCCGGCGCCATGGTGGCTCTGGCCCAGAAC TGGACGACGGTGGCCCCTCAGCGGAAATGCACCATCGACATCCTCACTGAGCCCAAGGAC ATCGGGAAGCGGCTGGAGGTGCGGAAGACCGTGACCGCCTGCCTGGGGGAGCCCAGCCAC ATCACGCGGCTGGAGCATGCTCAGGCACGGCTCACCCTGTCCTACAACCGCCGCGGTGAC CTTGCCATCCACCTGGTCAGCCCCATGGGCACCCGCTCCACCCTGCTGGCTGCCAGGCCA CATGACTACTCTGCAGATGGGTTTAACGACTGGGCCTTCATGACGACCCATTCCTGGGAC GAGGATCCCTCTGGCGAGTGGGTCTTAGAGATTGAAAACACCAGTGAAGCCAACAACTAT GGGACACTGACCAAGTTCACCCTCGTGCTTTATGGCACGGCCCCTGAGGGTTTGCCCACA CCCCCTGAGAGCATCGGCTGTAAGACCCTCACTTCCAGTCAGGCCTGTGTGGTGTGCGAG GAAGGCTTCTCCTTGCACCAGAAGAACTGCGTCCAGCACTGTCCCCCAGGCTTCGCTCCC CAAGTCCTGGACACACACTACAGCACAGAGAACGACGTGGAGATCATCCGGGCCAGCGTC TGCACGCCCTGCCACGCCTCGTGCGCCACGTGCCAGGGCCCCGCCCCCACAGACTGCCTC AGCTGCCCCAGCCACGCCTCCCTGGACCCGGTGGAGCAGACGTGCTCGCGCCAGAGCCAG AGCAGCCGCGAGTCGCACCAGCAGCAGCCGCCGCCGCCCCCTCGGCCACCGCCCGCGGAG GTAGCGACGGAGCCGCGGCTGCGGGCGGACCTGCTGCCCTCGCACCTGCCCGAGGTGGTG GCCGGCCTCAGCTGCGCCTTCATCGTGCTGGTCTTCGTTACCGTCTTCCTGGTCCTGCAG CTGCGCTCGGGCTTCAGCTTCCGAGGGGTGAAAGTGTACACCATGGACCGCGGCCTCATC TCCTACAAGGGACTACCCCCTGAAGCCTGGCAGGAGGAGTGCCCGTCCGACTCAGAGGAG GACGAGGGCCGGGGCGAGAGGACCGCCTTTATCAAAGACCAGAGCGCCCTTTGA 797 87251.0 6.39 719-739 1-26 >Furin MELRPWLFWVVAAAGALVLLVADARGEKVFTNTWAVHIPGGPAVADRVARKHGFLNLGQI FGDYYHFWHRAVTKRSLSPHRLGHNRLQREPQVKWLEQQVAKRRAKRDIYQEPTDPKFPQ QWYLSGVTQRDLNVKEAWAQGYTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL GLNPNHIHIYSASWGPEDDGKTVDGPAHLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC TESHTGTSAFAPLAAGIIALTLEANKNLTWRDMQHLVVRTSKPAHLNANDWATNGVGRKV SHSYGYGLLDAGAMVALAQNWTTVAPQRKCTIDILTEPKDIGKRLEVRKTVTACLGEPSH ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPTPPESIGCKTLTSSQACVVCE EGFSLHQKNCVQHCPPGFAPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCL SCPSHASLDPVEQTCSRQSQSSRESHQQQPPPPPRPPPAEVATEPRLRADLLPSHLPEVV AGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEE DEGRGERTAFIKDQSAL CAA53569.1 Q28193 FURIN_BOVIN 1P8J X75956 FURIN