1.0 2018-05-07 22:26:26 UTC 2020-05-20 21:06:49 UTC BMDBP01319 Enzyme HGS Involved in zinc ion binding Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). BMDB0000464 Calcium 19 >2334 bp ATGGGGCGTGGCAGTGGCACCTTCGAGCGTCTCCTAGACAAAGCGACCAGCCAGCTTCTT CTGGAGACTGACTGGGAGTCCATCCTCCAGATCTGTGACCTGATCCGCCAGGGGGACACG CAGGCAAAATATGCAGTGAGTTCCATCAAGAAGAAAGTTAATGATAAGAATCCCCACGTG GCCTTGTACGCCCTAGAGGTCATGGAGTCTGTGGTGAAGAATTGCGGCCAGACAGTCCAT GATGAGGTGGCAAACAAGCAGACCATGGAGGAGCTGAAGGATCTGCTGAAGAGGCAGGTG GAAGTAAACGTCCGGAACAAGATCCTGTATCTGATTCAGGCCTGGGCACACGCCTTCCGG AACGAGCCCAAGTACAAGGTGGTCCAGGACACGTACCAGATCATGAAGGTGGAAGGACAC GTCTTCCCAGAGTTCAAGGAAAGCGATGCCATGTTTGCTGCGGAGAGAGCCCCTGACTGG GTGGATGCTGAGGAGTGCCACCGGTGCCGGGTGCAGTTTGGGGTCATGACCCGCAAGCAC CACTGCCGGGCGTGTGGCCAGATCTTCTGCGGCAAGTGCTCTTCCAAGTACTCCACCATC CCCAAGTTCGGCATTGAGAAGGAGGTGCGGGTGTGTGAGCCCTGCTTTGAGCAGCTCAAC AAGAAAGCGGAGGGAAAAGCGGCCTCGACGACGGAGCTGCCCCCGGAGTACCTGACCAGC CCGCTGTCTCAGCAGTCGCAGCTGCCCCCTAAAAGGGATGAGACAGCCCTGCAGGAAGAG GAGGAGCTGCAGCTGGCCCTGGCCCTGTCTCAGTCGGAGGCCGAGGAGAAGGAACGGATG AGGCAGAAGTCGGCCTATACCGCGTACCCCAAGGCGGAACCCACGCCCGTGGCCTCCTCA GCACCCCCCGCCAGCAGCCTGTATTCTTCGCCTGTGAACTCGTCGGCGCCTCTGGCTGAG GACATCGATCCTGAGCTTGCGCGGTACCTGAACCGGAACTACTGGGAGAAGAAGCAGGAG GAGGCTCGGAAGAGCCCCACGCCGTCCGCGCCGGTGCCTCTGACAGAGCCCACGGCCCAG CCTGGGGAGGGACACGCAATCCCTGCCAACGTGGAGACTTCCCTCCCAGAGACAGACCCT CAGGCCGTAACTGCAGCCGGAGCTGCCTTTAGTGAGCAGTACCAGAATGGGGAGTCCGAG GAGAGCCACGCACAGTTCCTGAAGGCCCTCCAGAATGCCGTCACCACCTTCGTCAACCGC ATGAAGAGCAACCACGTGCGGGGCCGCAGCATCACCAACGACTCGGCCGTGCTGTCCCTC TTCCAGTCCATCAACACCATGCACCCCCAGCTGCTGGAGCTGCTCAACCAGCTGGATGAG CGCAGGTTATACTACGAGGGACTGCAGGACAAGCTGGCACAGATCCGTGATGCCCGGGGG GCACTCAGCGCCCTGCGGGAGGAGCACCGGGAGAAGCTTCGCCGCGCAGCTGAGGAGGCT GAGCGCCAGCGCCAGATCCAGCTGGCCCAGAAGCTGGAGATCATGCGGCAGAAGAAGCAG GAGTACTTAGAGGTGCAGCGGCAGCTGGCCATCCAGCGCCTGCAGGAGCAGGAGAAGGAG CGGCAAATGCGCCTGGAGCAGCAGAAGCAGACCATCCAGATGCGGGCCCAGATGCCCGCT TTCTCCCTGCCCTACGCCCAGCTCCAGGCCATGCCTGCAGCAGGGGGCGTGCTGTACCAG CCTTCCGGCCCGGCGAGCTTCGCGGGCACCTTCAGCCCGGCCGGCTCGGTGGAGGGCTCG CCCATGCACACCATGTACATGAGTCAGCCGGCCCCGGCTGCCAGCGGCCCCTACCCCAGC ATGCCAGCAGCCGCAGCAGACCCCAGCATGGTGAGCGCTTACATGTACCCAGCAGGGGCG GCTGGTGCACAGGCAGCCGCACAGGGCCCCGCAGGGCCCACCACCAGCCCAGCCTACTCA TCATACCAGCCTACTCCCACGCAGGGCTATCAGACCGTGGCCTCCCAGGCCCCACAGAGC CTCCCAGCCATCTCCCAGCCCCCGCAGTCTGGTACGATGGGCTACATGGGGAGCCAGTCA GTGTCCATGGGCTACCAGCCTTATAGCATGCAGAATCTCATGCCGACCCTCCCCGGCCAA GACGCGCCTCTGCCGCCCCCACAGCAACCCTATATCTCAGGGCAGCAGCCCGTGTACCAG CAGATGGCGCCCTCCAGCGGCCCTCCTCAGCAGCAGCCCCCAGTGGCCCAGCAGCCCCCA GCACAGGGCCCGCCAGCACAGGGCAGTGAAGCCCAGCTCATCTCGTTTGACTGA 777 85786.0 6.1 None >Hepatocyte growth factor-regulated tyrosine kinase substrate MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHV ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQLNKKAEGKAASTTELPPEYLTS PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKSAYTAYPKAEPTPVASS APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPTAQ PGEGHAIPANVETSLPETDPQAVTAAGAAFSEQYQNGESEESHAQFLKALQNAVTTFVNR MKSNHVRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARG ALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKE RQMRLEQQKQTIQMRAQMPAFSLPYAQLQAMPAAGGVLYQPSGPASFAGTFSPAGSVEGS PMHTMYMSQPAPAASGPYPSMPAAAADPSMVSAYMYPAGAAGAQAAAQGPAGPTTSPAYS SYQPTPTQGYQTVASQAPQSLPAISQPPQSGTMGYMGSQSVSMGYQPYSMQNLMPTLPGQ DAPLPPPQQPYISGQQPVYQQMAPSSGPPQQQPPVAQQPPAQGPPAQGSEAQLISFD ABG66987.1 Q0V8S0 HGS_BOVIN BT026148 HGS