| Identification |
|---|
| BMDB Protein ID
| BMDBP01331 |
| Secondary Accession Numbers
| None |
| Name
| Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ACAP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF GTPase activator activity |
| Specific Function
| GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| ACAP1 |
| Gene Sequence
|
>2238 bp
ATGACGGTCAAGCTGGATTTTGAGGAGTGTCTTAAGGACTCACCCCGCTTCCGAGCCTCT
GTCGAGCTGGTGGAAGCCGAAGTGTCAGAATTGGAGACCCGGCTGGAAAAGCTCCTCAAA
CTGGGGAATGGCCTCCTGGAAAGTGGGCGGCACTACCTTGCCGCCAGCCGGGCCTTCATC
GTGGGCATTTGTGATCTTGCCCACCTGGGACCACCAGAGCCCATGATGGCGGAGTGTCTG
GACAAATTCACTCAGAGCCTGAGCCATAAGCTGGACAGCCATGCTGAGCTTCTCGACGCC
ACCCAGCACACACTGCAGCGGCAAATTCAGACCTTGGTCAAGGAAGGTCTCCGGAGCTTC
CGAGAGGCTGGCCGGGATTTCTGGCGGGGGGCCGAGAGCCTGGAGGCTGCTCTTACCCAC
AATGCAGAGGTTCCCAGGCGCCGGGCCCAGGAGGCAGAAGAGGCTGGAGCTGCTTTGAAG
GTTGCTCGAGCTGGGTACCGGGGCCGGGCCCTGGACTATGCCCTGCAGATCAATGTGATT
GAGGACAAGAGGAAGTTTGACATCATGGAGTTTGTGCTGCGTTTGGTGGAGGCCCAGGCT
ACCCATTTCCAGCAGGGCCACGAGGAGCTGAGCCAGCTGGCCCAGTATCGCAAGGAGCTG
GGTGGCCAGTTACACCAGCTGGTCCTGAATTCAGCCCGCGAGAAGAGGGACATGGAGCAG
AGACATGTGCTGCTAAAACAGAAGGAGCTGGGTGGGGAGGAGCCAGAGCCAAGCCTAAAG
GAGGGGCCTGGTGGCTTGGTCATGGAAGGACATCTCTTCAAAAGGGCCAGCAATGCATTT
AAGACCTGGAGCAGACGCTGGTTCACTATTCAGAGCAACCAACTGGTCTATCAGAAGAGG
TACAAGGACCCTGTGACCGTGGTGGTGGATGACCTTCGTCTCTGCACAGTGAAGCTCTGT
CCTGACTCAGAAAGACGGTTCTGCTTTGAGGTTGTGTCCCCCAGCAAGTCTTGCCTCCTG
CAGTCTGACTCAGAGCGCCTCATGCAGCTGTGGGTCAGCGCCGTGCAGAGCAGCATCGCC
ACAGCCTTCAGCCAGGCTCGCCTTGATGACAGCCCCCGGGGTCTAGGCCAGGGCTCAGGA
CACCTGGCCATAAGCTCCGCTGCCACCCTGGGCCCTGGTGGGTTGACCAGGGGAAGGGAG
CCTGGGGGAGTGGGGCACGTGGCAGCCCAGGTGCAGAGCGTGGACGGCAATGCCCAGTGC
TGTGACTGCCGGGAGCCTGCCCCCGAGTGGGCCAGCATCAACCTCGGCGTCACCCTCTGC
ATTCAGTGCTCTGGCATTCACAGGAGCCTTGGAGTTCATTTCTCCAAAGTCCGGTCTCTG
ACCCTTGACTCATGGGAGCCGGAACTCGTGAAGCTCATGTGTGAGCTGGGAAATGTCGTC
ATAAACCAGATCTATGAAGCCCGAGTGGAGGCCATGGCTGTGAAGAAGCCAGGACCCAGC
TGCTCCCGGCAAGAGAAGGAGGCCTGGATTCATGCTAAATACGTGGAGAAGAAGTTCCTG
ACCAAGCTTCCTGAGATTCGAGGGCGAAGAGGTGGCCGGGGGCCCCCCAGGGGACATCCT
CCTGTGCCCCCAAAGCCAGGGCTTATCAGGCCCAAGCCGGGGAGCTTCAGATCCAAGCCA
GAGCCCCCCTCTGAGGACCTGCAGAGCCTGCACCCTGGGGCCCTGCTCTTTCGAGCTGCT
GGGCACCCTCCATCCCTTCCCACCATGGCTGATGCCCTTGCCCATGGAGCCGATGTCAAC
TGGGTCAACGGGGGTCAGGAGAATGCCACACCGCTGATCCAGGCCACAGCTGCTGTGAGA
GTCTTGAATTCTCTTCTGGCCTGTGAGTTTCTCCTCCAGAACGGGGCAAACGTGAACCAG
GTGGACAACCAAGGCCGGGGCCCGCTCCACCACGCGACAATTCTTGGCCACACGGGGCTG
GCCTGCCTGTTTCTGAAACGGGGAGCCGATCTAGGAGTTCGAGACTCTGAAGGCAGAGAC
CCCCTGACCATCGCCGTGGAAACAGCCAACGCTGACATCGTCACTCTGCTACGATTGGCA
AAAATGCGGGAGGCCGACGCAGCCCAGGGCCAGGCTGGAGACGAGACATATCTTGACATC
TTCCGTGATTTCTCCCTCATGGCATCCGACGACCCGGAGAAGCTGAGCCGGCGTAGTCAT
GACCTCCACACGCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 745 |
| Molecular Weight
| 82129.0 |
| Theoretical pI
| 7.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
MTVKLDFEECLKDSPRFRASVELVEAEVSELETRLEKLLKLGNGLLESGRHYLAASRAFI
VGICDLAHLGPPEPMMAECLDKFTQSLSHKLDSHAELLDATQHTLQRQIQTLVKEGLRSF
REAGRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALKVARAGYRGRALDYALQINVI
EDKRKFDIMEFVLRLVEAQATHFQQGHEELSQLAQYRKELGGQLHQLVLNSAREKRDMEQ
RHVLLKQKELGGEEPEPSLKEGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKR
YKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSPSKSCLLQSDSERLMQLWVSAVQSSIA
TAFSQARLDDSPRGLGQGSGHLAISSAATLGPGGLTRGREPGGVGHVAAQVQSVDGNAQC
CDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVV
INQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHP
PVPPKPGLIRPKPGSFRSKPEPPSEDLQSLHPGALLFRAAGHPPSLPTMADALAHGADVN
WVNGGQENATPLIQATAAVRVLNSLLACEFLLQNGANVNQVDNQGRGPLHHATILGHTGL
ACLFLKRGADLGVRDSEGRDPLTIAVETANADIVTLLRLAKMREADAAQGQAGDETYLDI
FRDFSLMASDDPEKLSRRSHDLHTL
|
| External Links |
|---|
| GenBank ID Protein
| AAI42329.1 |
| UniProtKB/Swiss-Prot ID
| A5PK26 |
| UniProtKB/Swiss-Prot Entry Name
| ACAP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142328 |
| GeneCard ID
| ACAP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
