Showing Protein Erlin-2 (BMDBP01336)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01336 |
| Secondary Accession Numbers | None |
| Name | Erlin-2 |
| Synonyms | Not Available |
| Gene Name | ERLIN2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 27 |
| Locus | Not Available |
| SNPs | ERLIN2 |
| Gene Sequence |
>1017 bp ATGGCTCAGTTGGGAGCGGTTGTGGCTGTGGCTGCCAGTTTCTTTTGTGCATCTCTCTTC TCGGCAGTGCACAAGATAGAAGAGGGACATATTGGGGTGTATTACAGAGGTGGTGCCCTG CTGACTTCCACCAGCGGCCCTGGCTTCCATCTCATGCTTCCTTTCATCACATCATATAAG TCTGTGCAGACCACACTCCAGACAGATGAGGTGAAGAATGTGCCTTGTGGGACAAGCGGT GGCGTGATGATCTACTTCGACAGGATCGAGGTGGTGAACTTCCTGGTCCCACACGCAGTG TATGACATAGTGAAGAACTACACAGCCGATTACGACAAGGCCCTCATCTTCAACAAGATC CACCATGAGTTGAACCAATTCTGCAGTGTCCACACGCTTCAGGAGGTCTACATCGAGCTC TTCGATCAGATTGATGAAAATCTCAAACTGGCTCTGCAACAAGACCTGACCTCCATGGCC CCTGGGCTTGTCATCCAAGCTGTGCGGGTGACAAAGCCCAACATCCCAGAAGCCATCCGC AGGAACTATGAGCTGATGGAAAGCGAGAAGACTAAGCTCCTGATCGCAGCCCAGAAGCAG AAGGTGGTAGAGAAGGAAGCCGAGACAGAGCGGAAGAAGGCCCTCATTGAGGCAGAGAAG GTGGCGCAGGTGGCCGAAATCACCTTTGGGCAGAAGGTGATGGAGAAGGAGACAGAGAAG AGGATCTCAGAGATTGAAGATGCTGCGTTCCTGGCCCGGGAGAAGGCCAAGGCAGACGCC GAGTGCTACACTGCCATGAAAATAGCCGAAGCAAATAAGCTGAAGCTGACCCCTGAGTAT CTGCAGCTGATGAAGTACAAGGCCATTGCTTCCAACAGCAAGATTTACTTTGGCAAAGAC ATCCCTAACATGTTCATGGACTCTGCGGGCGGCGTGGGCAAGCAGTTTGAAGGACTGGCT GACAAGCTGAGCTTTGTCTTGGAAGATGAGCCCATGGAGGCAGACTCCGAGAACTGA |
| Protein Properties | |
| Number of Residues | 338 |
| Molecular Weight | 37730.0 |
| Theoretical pI | 5.18 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Erlin-2 MAQLGAVVAVAASFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYK SVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKI HHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIR RNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITFGQKVMEKETEK RISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKD IPNMFMDSAGGVGKQFEGLADKLSFVLEDEPMEADSEN |
| External Links | |
| GenBank ID Protein | AAI14708.1 |
| UniProtKB/Swiss-Prot ID | Q1RMU4 |
| UniProtKB/Swiss-Prot Entry Name | ERLN2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC114707 |
| GeneCard ID | ERLIN2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |