1.0 2018-05-07 22:26:33 UTC 2020-05-20 21:07:42 UTC BMDBP01344 Enzyme KCNMA1 Inorganic ion transport and metabolism Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity). BMDB0000464 Calcium BMDB0000547 Magnesium BMDB0000586 Potassium BMDB0001361 Carbon monoxide BMDB0003178 Heme 28 >3501 bp ATGGCAAATGGTGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGC AGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCTTCTTCCTCC TCCTCCTCTTCCTCGTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCG GTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGGATGTGGTGGGCTTTCCTGGCC TCCTCCATGGTGACTTTCTTCGGCGGCCTCTTCATCATCTTGCTCTGGAGGACGCTCAAG TACCTGTGGACCGTTTGCTGCCACTGCGGGGGCAAAACGAAGGAGGCCCAGAAGATTAAC AATGGCTCAAGCCAGGCAGATGGCACTCTCAAGCCAGTGGATGAAAAAGAGGAGACGGTG GCAGCCGAGGTCGGCTGGATGACCTCCGTGAAAGACTGGGCGGGGGTGATGATATCTGCC CAGACGCTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATTGGTGCACTT GTAATATACTTCATAGATTCGTCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGAT TTCACATTACAGATCGACATGGCGTTCAACGTATTCTTCCTTCTCTACTTTGGCTTGCGG TTTATTGCAGCCAACGATAAGCTATGGTTCTGGCTTGAAGTGAACTCTGTGGTAGATTTC TTCACGGTCCCCCCTGTGTTTGTGTCCGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGA TTTTTAAGAGCTCTCAGACTGATCCAGTTTTCAGAAATTTTACAGTTTCTGAATATCCTG AAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATTTTTATCAGCACGTGGCTC ACAGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAA AACAACCAGGCTCTTACCTACTGGGAATGTGTCTATCTGCTCATGGTGACCATGTCCACT GTTGGTTACGGGGATGTTTATGCAAAAACCACGCTCGGGCGTCTCTTCATGGTCTTCTTC ATCCTCGGGGGACTGGCCATGTTTGCCAGCTACGTCCCTGAAATCATAGAGTTAATAGGA AACCGCAAGAAATACGGGGGCTCCTATAGTGCGGTTAGTGGAAGAAAGCACATAGTGGTC TGTGGACACATCACACTGGAGAGCGTTTCCAACTTCCTGAAGGACTTTCTGCACAAGGAC CGGGACGATGTCAATGTGGAGATCGTCTTTCTTCACAACATCTCCCCTAACCTGGAGCTG GAAGCCTTGTTCAAACGACATTTTACTCAGGTGGAGTTTTATCAGGGTTCAGTCCTCAAT CCACATGATCTTGCAAGAGTCAAGATAGAGTCAGCAGATGCGTGCCTGATCCTTGCCAAT AAGTACTGCGCAGACCCCGATGCTGAAGATGCCTCCAACATCATGAGAGTCATCTCCATA AAGAACTACCACCCGAAGATAAGAATCATCACTCAGATGCTGCAGTATCACAATAAGGCC CATCTGCTAAACATCCCGAGCTGGAATTGGAAAGAGGGGGATGATGCAATCTGCCTCGCA GAACTGAAGCTGGGGTTCATCGCCCAGAGCTGCCTGGCTCAAGGGCTCTCCACCATGCTC GCCAACCTCTTCTCCATGAGGTCATTCATAAAGATTGAGGAAGACACGTGGCAGAAATAC TACTTGGAAGGAGTCTCAAATGAAATGTACACAGAATATCTCTCCAGTGCCTTCGTGGGT CTGTCCTTCCCGACTGTTTGTGAGCTGTGTTTTGTGAAGCTCAAGCTTCTCATGATAGCC ATTGAGTACAAGTCCGCCAATCGAGAGAGCCGTATATTAATTAATCCTGGAAACCATCTT AAGATCCAAGAAGGTACTTTAGGATTTTTCATCGCAAGTGATGCCAAAGAAGTTAAAAGG GCATTTTTTTACTGCAAGGCCTGTCATGATGACATCACGGATCCCAAAAGGATAAAAAAA TGCGGCTGCAAACGGCTTGAAGATGAACAGCCGTCGACACTGTCACCCAAAAAAAAGCAG CGCAACGGAGGCATGCGGAACTCACCCAGCTCGTCGCCCAAGCTGATGAGGCATGACCCC TTGTTAATTCCTGGCAATGATCAGATTGACAACATGGACTCCAATGTGAAGAAATATGAC TCTACTGGGATGTTTCACTGGTGTGCGCCCAAGGAGATAGAGAAAGTCATCCTGACCCGA AGTGAAGCTGCCATGACCGTCCTGAGCGGCCACGTGGTGGTCTGCATCTTTGGCGACGTC AGCTCTGCCCTGATTGGCCTTCGGAACCTGGTGATGCCGCTCCGTGCCAGCAACTTTCAC TACCACGAGCTCAAGCACATCGTGTTTGTGGGCTCCATCGAGTACCTCAAGCGGGAATGG GAGACACTGCATAACTTCCCCAAGGTTTCCATCTTGCCTGGTACGCCATTAAGTCGGGCT GATTTAAGGGCCGTCAACATCAACCTCTGTGACATGTGCGTTATCCTGTCAGCCAATCAG AATAATATTGATGATACTTCGCTGCAGGACAAGGAATGCATCTTGGCGTCACTCAACATC AAATCTATGCAGTTTGATGACAGCATCGGGGTCTTGCAGGCTAATTCCCAAGGGTTCACA CCTCCAGGAATGGACCGATCCTCACCAGATAACAGCCCGGTACATGGGATGTTACGCCAG CCCTCCATCACTACTGGGGTCAACATCCCCATCATCACTGAACTAGTGAACGATACTAAT GTTCAGTTTTTGGACCAAGACGATGACGATGACCCCGACACAGAACTGTACCTCACGCAG CCGTTTGCATGTGGGACAGCGTTCGCCGTCAGTGTCCTGGATTCACTCATGAGCGCAACA TACTTCAATGACAACATCCTTACCCTGATACGGACCCTGGTGACTGGAGGAGCCACACCA GAGCTGGAGGCTTTGATCGCTGAGGAGAATGCACTCCGCGGGGGCTACAGCACCCCCCAG ACGCTGGCCAACAGGGACCGCTGCCGTGTGGCCCAGTTAGCGCTGCTGGACGGGCCCTTT GCGGACCTGGGGGATGGTGGTTGTTATGGTGATCTGTTCTGCAAAGCTCTGAAAACATAC AATATGCTTTGTTTTGGAATTTATCGGCTGAGAGATGCTCACCTCAGCACCCCCAGCCAG TGCACGAAGAGGTATGTCATCACCAACCCCCCGTACGAGTTTGAGCTCGTGCCGACGGAC CTGATCTTCTGCTTAATGCAGTTTGACCACAACGCCGGCCAGTCCCGGGCCAGCCTCTCC CATTCCTCCCACTCGTCCCAGTCCTCTAGCAAGAAGAGCTCCTCCGTCCACTCCATCCCA TCCACGGCAAACCGACAGAACCGGCCCAAGTCCCGGGAGTCCCGAGACAAACAGAAGTAC GTGCAGGAAGAGCGGCTCTGA 1166 130063.0 6.76 75-95 167-187 203-223 228-248 253-273 289-309 356-376 None >Calcium-activated potassium channel subunit alpha-1 MANGGGGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSVHEPKMDALIIP VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKIN NGSSQADGTLKPVDEKEETVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGAL VIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWL TAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFF ILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKD RDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILAN KYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLA ELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVG LSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKR AFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPSSSPKLMRHDP LLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDV SSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFT PPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQ PFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQ TLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQ CTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIP STANRQNRPKSRESRDKQKYVQEERL AAK54352.1 Q28204 KCMA1_BOVIN AY033472 KCNMA1