| Identification |
|---|
| BMDB Protein ID
| BMDBP01370 |
| Secondary Accession Numbers
| None |
| Name
| Serum albumin |
| Synonyms
|
Not Available
|
| Gene Name
| ALB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in copper ion binding |
| Specific Function
| Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| ALB |
| Gene Sequence
|
>1824 bp
ATGAAGTGGGTGACTTTTATTTCTCTTCTCCTTCTCTTCAGCTCTGCTTATTCCAGGGGT
GTGTTTCGTCGAGATACACACAAGAGTGAGATTGCTCATCGGTTTAAAGATTTGGGAGAA
GAACATTTTAAAGGCCTGGTACTGATTGCCTTTTCTCAGTATCTCCAGCAGTGTCCATTT
GATGAGCATGTAAAATTAGTGAACGAACTAACTGAGTTTGCAAAAACATGTGTTGCTGAT
GAGTCCCATGCCGGCTGTGAAAAGTCACTTCACACTCTCTTTGGAGATGAATTGTGTAAA
GTTGCATCCCTTCGTGAAACCTATGGTGACATGGCTGACTGCTGTGAGAAACAAGAGCCT
GAAAGAAATGAATGCTTCCTGAGCCACAAAGATGATAGCCCAGACCTCCCTAAATTGAAA
CCAGACCCCAATACTTTGTGTGATGAGTTTAAGGCAGATGAAAAGAAGTTTTGGGGAAAA
TACCTATACGAAATTGCTAGAAGACATCCCTACTTTTATGCACCAGAACTCCTTTACTAT
GCTAATAAATATAATGGAGTTTTTCAAGAATGCTGCCAAGCTGAAGATAAAGGTGCCTGC
CTGCTACCAAAGATTGAAACTATGAGAGAAAAGGTACTAGCTTCATCTGCCAGACAGAGA
CTCAGGTGTGCCAGTATTCAAAAATTTGGAGAAAGAGCTTTAAAAGCATGGTCAGTAGCT
CGCCTGAGCCAGAAATTTCCCAAGGCTGAGTTTGTAGAAGTTACCAAGCTAGTGACAGAT
CTCACAAAAGTCCACAAGGAATGCTGCCATGGTGACCTACTTGAATGCGCAGATGACAGG
GCAGATCTTGCCAAGTACATATGTGATAATCAAGATACAATCTCCAGTAAACTGAAGGAA
TGCTGTGATAAGCCTTTGTTGGAAAAATCCCACTGCATTGCTGAGGTAGAAAAAGATGCC
ATACCTGAAAACCTGCCCCCATTAACTGCTGACTTTGCTGAAGATAAGGATGTTTGCAAA
AACTATCAGGAAGCAAAAGATGCCTTCCTGGGCTCGTTTTTGTATGAATATTCAAGAAGG
CATCCTGAATATGCTGTCTCAGTGCTATTGAGACTTGCCAAGGAATATGAAGCCACACTG
GAGGAATGCTGTGCCAAAGATGATCCACATGCATGCTATTCCACAGTGTTTGACAAACTT
AAGCATCTTGTGGATGAGCCTCAGAATTTAATCAAACAAAACTGTGACCAATTCGAAAAA
CTTGGAGAGTATGGATTCCAAAATGCGCTCATAGTTCGTTACACCAGGAAAGTACCCCAA
GTGTCAACTCCAACTCTCGTGGAGGTTTCAAGAAGCCTAGGAAAAGTGGGTACTAGGTGT
TGTACAAAGCCGGAATCAGAAAGAATGCCCTGTACTGAAGACTATCTGAGCTTGATCCTG
AACCGGTTGTGCGTGCTGCATGAGAAGACACCAGTGAGTGAAAAAGTCACCAAGTGCTGC
ACAGAGTCATTGGTGAACAGACGGCCATGTTTCTCTGCTCTGACACCTGATGAAACATAT
GTACCCAAAGCCTTTGATGAGAAATTGTTCACCTTCCATGCAGATATATGCACACTTCCC
GATACTGAGAAACAAATCAAGAAACAAACTGCACTTGTTGAGCTGTTGAAACACAAGCCC
AAGGCAACAGAGGAACAACTGAAAACCGTCATGGAGAATTTTGTGGCTTTTGTAGACAAG
TGCTGTGCAGCTGATGACAAAGAAGCCTGCTTTGCTGTGGAGGGTCCAAAACTTGTTGTT
TCAACTCAAACAGCCTTAGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 607 |
| Molecular Weight
| 69293.0 |
| Theoretical pI
| 6.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serum albumin
MKWVTFISLLLLFSSAYSRGVFRRDTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPF
DEHVKLVNELTEFAKTCVADESHAGCEKSLHTLFGDELCKVASLRETYGDMADCCEKQEP
ERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYY
ANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCASIQKFGERALKAWSVA
RLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKE
CCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRR
HPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEPQNLIKQNCDQFEK
LGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLIL
NRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLP
DTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVV
STQTALA
|
| External Links |
|---|
| GenBank ID Protein
| AAA51411.1 |
| UniProtKB/Swiss-Prot ID
| P02769 |
| UniProtKB/Swiss-Prot Entry Name
| ALBU_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M73993 |
| GeneCard ID
| ALB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
