| Identification |
|---|
| BMDB Protein ID
| BMDBP01376 |
| Secondary Accession Numbers
| None |
| Name
| Acidic amino acid decarboxylase GADL1 |
| Synonyms
|
Not Available
|
| Gene Name
| GADL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate. |
| Pathways
|
- Taurine and Hypotaurine Metabolism
|
| Reactions
|
| 3-Sulfinoalanine → Hypotaurine + Carbon dioxide |
details
|
| Cysteic acid → Taurine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| GADL1 |
| Gene Sequence
|
>1509 bp
ATGGTTCCAAGCAGGAAGAACGTGGTTCTCGTGGATGGAGTCATACTGAACGGCCCCGCA
ACAGATGTAAAAGCAGGAGAAAAATTTGTGGAAGATGCCTGTAGACTAATAATGGAAGAG
GTGGTTTTGAAGGCTACAGACATCAATGAGAAGGTCTGTGAGTGGCGGCCCCCTGAAGAG
CTGAAGCGGCTTCTCGACTTGGAGCTGAGGGACGCGGGAGAGCCGCACCACCGGCTGCTG
CAGCGCTGCCAGGACGTCATACGCTACAGCGTCAAGACCAACCATCCAAGATTTTTCAAC
CAGTTATATGCTGGACTTGATTATTACTCTTTGGTGGCCAGATTTATGACAGAAGCATTA
AACCCAAGTGTTTATACGTATGAGGTGTCCCCAGTGTTTCTGTTGGTAGAAGAAGCGGTT
CTGAAGAAAATGATTGAATTTATTGGCTGGAAAGAAGGGGATGGAATATTTAACCCAGGT
GGTTCAGTGTCCAATATGTATGCCATGAATTTAGCCAGATACAAGTACTGTCCTGATATT
AAGGAAAAGGGGCTGTCTGGCTTGCCAAGATTAATCCTTTTCACATCTGCAGAGTGTCAT
TACTCCATGAAGAAGTCTGCTTCCTTTCTTGGGATTGGTACTGAGAATGTGTGCTTTGTG
GAGACAGATGGAAGAGGTAAGATGATACCTGAGGAGCTGGAGAAGCGCGTGCAGGAGGCC
AAGAAAGAGGGTGCAGCTCCGTTCCTTGTGTGTGCCACGTCTGGTACCACCGTGCTGGGG
GCCTTCGATCCTCTGGATGAGATAGCGGACATCTGCGAGAGGCACGGCCTCTGGCTCCAT
GTAGACGCTTCTTGGGGTGGCTCAGCCTTGATGTCCAGGAAGCACCGCAGGCTCCTGCAG
GGTATCCACAGAGCTGATTCTGTGGCGTGGAACCCACACAAAATGTTGATGGCTGGGATT
CAGTGCTGCGCTTTCCTCGTCAAAGACAAATCTGACCTTCTTAAGAGATGCTACTCGGCC
AACGCGTCTTACCTCTTCCAGCAGGATAAATTTTATGATGTCAGCTATGACACAGGCGAC
AAATCCATCCAATGCAGCAGGAGACCAGATGCATTCAAGTTCTGGCTGGCCTGGAAGGCC
CTGGGCACGCTAGGCCTTGAGGAAAGAGTTAACCGCGCTCTTGCTTTATCTAGGTACCTA
GTAGAAGAAATCAAGAAAAGAGAAGGATTCAAGTTACTGATGGAACCTGAATATGCCAAT
ATTTGCTTTTGGTACATTCCACCAAGCCTCAGACAGATGGAGGAAGGACCTGAGTTCTGG
GCAAAACTTCATTTGGTGGCCCCGGCCATTAAGGAGCGGATGATGAAGAAGGGGAGCCTC
ATGCTGGGCTACCAGCCACACCAGGGGAAAGTCAACTTCTTCCGGCAGGTGGTGATCAGC
CCTCAAGTCAGCCGGGAGGACATGGACTTCCTGCTGGATGAGATAGACCTCCTGGGGAAG
GACATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 521 |
| Molecular Weight
| 59380.0 |
| Theoretical pI
| 6.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutamate decarboxylase-like protein 1
MSLLPDRERAPDGDISPQEMVPSRKNVVLVDGVILNGPATDVKAGEKFVEDACRLIMEEV
VLKATDINEKVCEWRPPEELKRLLDLELRDAGEPHHRLLQRCQDVIRYSVKTNHPRFFNQ
LYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGG
SVSNMYAMNLARYKYCPDIKEKGLSGLPRLILFTSAECHYSMKKSASFLGIGTENVCFVE
TDGRGKMIPEELEKRVQEAKKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHGLWLHV
DASWGGSALMSRKHRRLLQGIHRADSVAWNPHKMLMAGIQCCAFLVKDKSDLLKRCYSAN
ASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWLAWKALGTLGLEERVNRALALSRYLV
EEIKKREGFKLLMEPEYANICFWYIPPSLRQMEEGPEFWAKLHLVAPAIKERMMKKGSLM
LGYQPHQGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM
|
| External Links |
|---|
| GenBank ID Protein
| AAI48147.1 |
| UniProtKB/Swiss-Prot ID
| A6QM00 |
| UniProtKB/Swiss-Prot Entry Name
| GADL1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC148146 |
| GeneCard ID
| GADL1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
