<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:26:43 UTC</creation_date>
  <update_date>2020-05-20 21:03:54 UTC</update_date>
  <accession>BMDBP01382</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>CCN2</gene_name>
  <general_function>Involved in heparin binding</general_function>
  <specific_function>Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001394</accession>
      <name>Heparin</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>9</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1050 bp
ATGTCAGCCACCGGCCTGGGCCCGGTCCGCTGCGCCTTCGTGCTCCTGCTCGCCCTCTGC
AGCCGGCCCGCCTCCAGCCAGGACTGCTGCAGCGCCCCGTGCCAGTGCCCTGCCGGCCCG
GCGCCGCGCTGCCCCGCCGGCGTCAGCTTGGTGCTGGACGGCTGCGGCTGCTGCGTGTGC
GCCAAGCAGCTGAGCGAGTTGTGTACCGAGCGCGACCCCTGCGATCCGCACAAGGGCCTC
TTCTGCGACTTCGGCTCCCCAACCAACCGCAAGATCGGCGTGTGCACCGCTAAAGATGGT
GCCCCCTACATTTTCGGAGGAACTGTGTACCAGAGCGGAGAGTCTTTCCAGAGCAGCTGC
AAATACCAGTGCACGTGTCTGGACGGGTCGGTGGGCTGCGTGCCCCTATGCAGCGTGGAC
GTCCGCCTGCCCAGCCCCGACTGCCCCTTCCCACGGAGGGTCAAACTGCCCGGGAAATGC
TGCGAGGAATGGGTGTCCCGTGATGAGAAGGAGCACACCGTGGTCGGCCCTGCGCTGGCA
GCTTACCGGCTGGAAGACACGTTTGGCCCAGACCCAACCATGATCCGAGCCAACTGCCAG
GTCCAGACCACAGAGTGGAGTGCCTATTCCAAGACCTGCGGAATGGGCATCTCCACCCGG
GTTACCAATGACAACGCATTCTGCAGGCTGGAGAAGCAGAGCCGCCTCTGCATGGTCAGG
CCTTGCGAAGCTGACCTGGAGGAGAACATTAAGAAAGGCAAAAAGTGCATCCGGACTCCC
AAAATCTCCAAGCCTATCAAGTTTCAGCTTTCTGGCTGCACCAGCATGAAGACATACCGA
GCTAAATTCTTCGGAGTGTGCACAGACGGGCGGTGCTGCACCCCCCACAGAACCACCACC
CTTCCCGTGGAGTTCAAGTGTCCTGATGGGGAGGTCATGAAGAAGAGCATGATGTTCATC
AAGACCTGTGCCTGCCATTACAACTGCCCCGGAGACAATGACATCTTCGAGTCACTGTAC
TACAGGAAGATGTATGGAGACATGGCCTAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>349</residue_number>
    <molecular_weight>37924.0</molecular_weight>
    <theoretical_pi>7.89</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>1-26</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Connective tissue growth factor
MSATGLGPVRCAFVLLLALCSRPASSQDCSAPCQCPAGPAPRCPAGVSLVLDGCGCCRVC
AKQLSELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYQSGESFQSSC
KYQCTCLDGSVGCVPLCSVDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALA
AYRPEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVR
PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT
LPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAB66596.1</genbank_protein_id>
  <uniprot_id>O18739</uniprot_id>
  <uniprot_name>CCN2_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>AF000137</genbank_gene_id>
  <genecard_id>CCN2</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
