| Identification |
|---|
| BMDB Protein ID
| BMDBP01391 |
| Secondary Accession Numbers
| None |
| Name
| Fibroblast growth factor 2 |
| Synonyms
|
Not Available
|
| Gene Name
| FGF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| FGF2 |
| Gene Sequence
|
>468 bp
CCCCGCCAGGGCCTTGGTGGGGCCATGGCCGCCGGGAGCATCACCACGCTGCCAGCCCTG
CCGGAGGACGGCGGCAGCGGCGCTTTCCCGCCGGGCCACTTCAAGGACCCCAAGCGGCTG
TACTGCAAGAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGCCGAGTGGACGGGGTC
CGCGAGAAGAGCGACCCACACATCAAACTACAACTTCAAGCAGAAGAGAGAGGGGTTGTG
TCTATCAAAGGAGTGTGTGCAAACCGTTACCTTGCTATGAAAGAAGATGGAAGATTACTA
GCTTCTAAATGTGTTACAGACGAGTGTTTCTTTTTTGAACGATTGGAGTCTAATAACTAC
AATACTTACCGGTCAAGGAAATACTCCAGTTGGTATGTGGCACTGAAACGAACTGGGCAG
TATAAACTTGGACCCAAAACAGGACCTGGGCAGAAAGCTATACTTTTT
|
| Protein Properties |
|---|
| Number of Residues
| 155 |
| Molecular Weight
| 17250.0 |
| Theoretical pI
| 10.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Heparin-binding growth factor 2
MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHI
KLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKY
SSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS
|
| External Links |
|---|
| GenBank ID Protein
| AAA30518.1 |
| UniProtKB/Swiss-Prot ID
| P03969 |
| UniProtKB/Swiss-Prot Entry Name
| FGF2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M13440 |
| GeneCard ID
| FGF2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
