1.0 2018-05-07 22:26:47 UTC 2020-05-20 21:03:59 UTC BMDBP01396 Enzyme SFRP1 Involved in protein binding Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. BMDB0001394 Heparin 27 >927 bp ATGGGCGGCGGGCGCTGGGCCGCGGCGGGCGCGCTGCTGGCGCTGGCCGCCGGGCTCCTG GCCGCGGGCTCGGCCAGCGAGTACGACTACGTGAGCTTCCAGTCGGACATCGGCGCCTAC CAGAGCGGGCGCTTCTACACCAAGCCACCGCAGTGCGTGGACATCCCGGCAGACCTGCGG CTGTGCCACAACGTGGGCTACAAGAGGATGGTGCTGCCCAACCTGCTGGAGCACGAGACC ATGGCCGAGGTGAAGCAGCAGGCCAGCAGCTGGGTGCCCCTGCTCAACAAGAACTGCCAC ATCGGCACCCAGGTCTTCCTGTGCTCGCTCTTCGCGCCCGTCTGCCTGGACCGGCCCATC TACCCGTGCCGCTGGCTCTGCGAGGCCGTGCGCGACTCGTGCGAGCCGGTCATGCAGTTC TTCGGCTTCTACTGGCCCGAGATGCTCAAGTGCGACAAGTTTCCCGAGGGCGACGTCTGC ATCGCCATGACCCCGCCCAACGCCACCGAGGCCTCCAAGCCCCAAGGCACGACCGTGTGT CCTCCATGTGACAACGAGCTGAAGTCTGAAGCCATCATTGAGCATCTCTGTGCCAGCGAG TTTGCCCTGAGGATGAAAATCAAAGAAGTGAAAAAGGAAAACGGCGACAAGAAGATTGTC CCCAAGAAGAAGAAGCCCCTGAAGCTGGGGCCCATCAAGAAGAAGGAGCTGAAGAAGCTG GTCCTATACCTGAAGAACGGGGCCGACTGCCCCTGCCACCAGCTGGACAACCTCAGCCAC CACTTCCTCATCATGGGCCGCAAGGTCAAGAGCCAGTACCTGCTGACCGCCATCCACAAG TGGGACAAGAAAAACAAGGAGTTCAAGACCTTCATGAAGAAGATGAAGAATCACGAGTGT CCCACTTTCCAGTCGGTCTTCAAGTGA 308 34763.0 8.99 1-25 >Secreted frizzled-related protein 1 MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLR LCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPI YPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVC PPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKL VLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKTFMKKMKNHEC PTFQSVFK AAB67062.1 O19116 SFRP1_BOVIN U85945 SFRP1