| Identification |
|---|
| BMDB Protein ID
| BMDBP01402 |
| Secondary Accession Numbers
| None |
| Name
| Antithrombin-III |
| Synonyms
|
Not Available
|
| Gene Name
| SERPINC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heparin binding |
| Specific Function
| Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| SERPINC1 |
| Gene Sequence
|
>1398 bp
ATGATTTCCAATGGGATAGGAACCGTCACCGCTGGAAAAAGGAGTATATGTCTTCTCCCT
TTGCTGCTTATTGGCCTCTGGGGCTGTGTGACCTGTCATCGGAGCCCTGTGGAAGACGTC
TGCACAGCCAAACCTCGGGACATTCCTGTGAATCCCATGTGTATTTACCGTTCCTCAGAG
AAGAAGGCAACTGAGGGCCAAGGCTCCGAGCAGAAGATCCCTGGGGCCACCAACCGGCGG
GTCTGGGAACTGTCCAAGGCCAATTCCCACTTTGCCACTGCCTTCTATCAGCATTTGGCA
GACTCCAAGAATAACAATGACAACATTTTCCTGTCACCCCTGAGTATCTCCACAGCTTTT
GCTATGACCAAGCTGGGTGCCTGTGACAACACACTCAAGCAGTTGATGGAGGTTTTTAAG
TTTGATACCATCTCTGAGAAAACTTCTGATCAGATCCACTTTTTCTTTGCCAAACTGAAC
TGCCGACTCTATCGAAAAGCCAATAAATCCTCTGAGTTGGTATCAGCCAACCGTCTTTTT
GGAGGCAAATCCATTACATTCAATGAGACCTACCAGGACATCAGTGAGGTGGTATATGGG
GCCAAGCTCCAGCCCCTGGACTTCAAGGGAAATGCAGAGCAGTCCAGATTGACTATCAAC
CAATGGATATCCAATAAGACTGAAGGGCGTATCACTGATGTCATTCCCCCACAAGCCATC
AATGAGTTCACTGTCCTGGTGCTAGTCAACACCATTTACTTCAAGGGCCTGTGGAAGTCA
AAGTTCAGTCCCGAGAACACAAGGAAGGAACTGTTCTACAAGGCTGATGGGGAGTCATGT
TCAGTACTCATGATGTACCAGGAAAGCAAGTTCCGCTATCGGAGAGTAGCAGAAAGCACC
CAGGTGCTCGAGTTGCCCTTCAAGGGTGATGACATCACCATGGTGCTCATCCTGCCCAAG
CTGGAGAAGACCCTGGCCAAGGTGGAACAGGAACTCACCCCAGACATGCTGCAGGAGTGG
CTGGATGAGCTGACAGAGACGCTGCTGGTGGTCCACATGCCCCGCTTCCGCATCGAGGAC
AGCTTCAGCGTGAAGGAGCAGCTGCAAGACATGGGCCTCGAAGACCTGTTCAGTCCTGAG
AAGTCCAGGCTCCCAGGTATTGTTGCAGAAGGTCGGAGCGACCTCTATGTCTCAGATGCA
TTCCACAAGGCATTTCTTGAGGTAAATGAGGAAGGCAGTGAAGCTGCAGCAAGTACCGTC
ATTAGCATCGCTGGTCGTTCGCTGAACTCGGACAGGGTGACCTTCAAGGCCAACAGGCCC
ATCCTGGTTCTCATCAGGGAAGTTGCTCTGAACACTATTATATTCATGGGTAGAGTAGCC
AACCCTTGTGTTGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 465 |
| Molecular Weight
| 52347.0 |
| Theoretical pI
| 7.38 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 109-135
- 191-214
- 263-287
- 348-372
- 384-404
- 416-435
- 447-471
- 478-510
|
| Protein Sequence
|
>Antithrombin-III
MISNGIGTVTAGKRSICLLPLLLIGLWGCVTCHRSPVEDVCTAKPRDIPVNPMCIYRSSE
KKATEGQGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAF
AMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLF
GGKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAI
NEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAEST
QVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIED
SFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTV
ISIAGRSLNSDRVTFKANRPILVLIREVALNTIIFMGRVANPCVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI02748.1 |
| UniProtKB/Swiss-Prot ID
| P41361 |
| UniProtKB/Swiss-Prot Entry Name
| ANT3_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102747 |
| GeneCard ID
| SERPINC1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
