| Identification |
|---|
| BMDB Protein ID
| BMDBP01412 |
| Secondary Accession Numbers
| None |
| Name
| Pleiotrophin |
| Synonyms
|
Not Available
|
| Gene Name
| PTN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:1550956) (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| PTN |
| Gene Sequence
|
>507 bp
ATGCAGACTCCACAGTACCTGCAGCAACGTCGAAAATTTGCAGCTGCCTTTTTGGCATTT
ATTTTCATCTTGGCAGCTGTGGACACCGCTGAAGCAGGAAAGAAAGAGAAACCAGAAAAG
AAGGTGAAGAAGTCTGACTGTGGAGAATGGCAGTGGAGTGTGTGTGTACCCACCAGTGGG
GACTGTGGGCTGGGCACCCGCGAGGGCACCCGTACCGGAGCTGAGTGTAAACAAACCATG
AAGACCCAGAGATGTAAGATCCCCTGCAACTGGAAAAAGCAATTTGGAGCGGAGTGCAAA
TACCAGTTCCAGGCCTGGGGAGAATGTGATCTGAACACGGCTCTGAAGACCCGAACTGGG
AGCCTGAAGCGAGCCCTCCACAACGCCGACTGCCAGAAGACAGTCACCATCTCCAAGCCC
TGTGGCAAGCTGACCAAGTCCAAACCTCAAGCAGAATCTAAGAAGAAGAAAAAGGAAGGC
AAGAAACAGGAGAAGATGCTGGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 168 |
| Molecular Weight
| 18902.0 |
| Theoretical pI
| 10.3 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 110-129
- 141-161
- 181-205
- 348-370
- 403-431
- 443-463
- 469-490
- 511-534
- 540-561
|
| Protein Sequence
|
>Pleiotrophin
MQTPQYLQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG
DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG
SLKRALHNADCQKTVTISKPCGKLTKSKPQAESKKKKKEGKKQEKMLD
|
| External Links |
|---|
| GenBank ID Protein
| CAA37120.1 |
| UniProtKB/Swiss-Prot ID
| P21782 |
| UniProtKB/Swiss-Prot Entry Name
| PTN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X52945 |
| GeneCard ID
| PTN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
