| Identification |
|---|
| BMDB Protein ID
| BMDBP01428 |
| Secondary Accession Numbers
| |
| Name
| Cytochrome b-245 heavy chain |
| Synonyms
|
Not Available
|
| Gene Name
| CYBB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| CYBB |
| Gene Sequence
|
>1713 bp
ATGGGGAACTGGGTTGTGAATGAGGGCATCTCCATCTTTGTCATTCTGGTATGGCTGGGG
ATGAACGTCTTCCTTTTTGTCTGGTACTACCGGGTTTATGATATCCCAGATAAGTTCTTT
TACACTCGAAAACTTCTTGGGTCAGCGCTGGCCCTGGCCAGAGCCCCTGCAGCCTGCCTG
AATTTCAACTGCATGCTGATTCTGCTGCCTGTCTGTCGAAATCTGCTCTCCTTCCTCAGG
GGTTCCAGTGCGTGCTGCTCAACAAGAATTCGGAGACAACTGGACAGGAACCTCACCTTT
CATAAAATGGTGGCATGGATGATTGCACTTCACACTGCAATTCATACCATTGCACATCTA
TTTAATGTGGAGTGGTGTGTGAATGCCCGAGTCAACAATTCTGATCCTTATTCAATAGCA
CTCTCTGACATTGGAGATAAGCCTAATGAAACTTACCTCAATTTTGTTCGACAGAGAATC
AAGAATCCTGAAGGAGGCCTGTATGTGGCTGTGACTCGGTTGGCAGGCATCACTGGAGTC
GTCATTACACTGTGCCTGATATTAATTATCACATCCTCCACCAAAACCATCCGGAGGTCT
TATTTTGAAGTGTTTTGGTACACACACCATCTCTTTGTGATCTTCTTCATTGGTCTCGCC
ATCCATGGAGCTCAGCGGATTGTACGTGGGCAGACTGCAGAGAGTTTGTTGAAACACCAA
CCAAGAAACTGTTATCAAAACATCTCACAGTGGGGAAAAATAGAGAACTGCCCAATCCCA
GAGTTCTCTGGGAACCCTCCTATGACTTGGAAATGGATAGTGGGTCCCATGTTCCTGTAT
CTCTGTGAGAGGTTGGTACGGTTTTGGAGATCTCAACAGAAGGTGGTCATCACCAAGGTG
GTCACTCACCCTTTCAAAACCATCGAGCTCCAGATGAAGAAGAAAGGATTCAAGATGGAG
GTGGGCCAATACATTTTCGTCAAGTGTCCCGTGGTGTCCAAGCTGGAGTGGCACCCTTTC
ACCCTGACCTCTGCCCCTGAGGAAGACTTCTTTAGCATCCATATCCGCATCGTGGGGGAC
TGGACAGAGGGACTCTTCAAAGCTTGTGGCTGTGATAAGCAGGAGTTTCAAGATGCCTGG
AAACTACCAAAGATAGCTGTTGACGGGCCCTTTGGCACTGCCAGTGAGGACGTGTTCAGT
TACGAGGTGGTGATGTTAGTGGGAGCAGGGATCGGGGTTACGCCCTTTGCATCCATCCTC
AAGTCGGTCTGGTACAAATATTGCAATAAAGCCCCAAATCTGAGGCTCAAAAAGATCTAC
TTCTACTGGCTGTGCCGGGACACACATGCCTTTGAGTGGTTTGCGGACCTGCTGCAGCTG
CTGGAAACACAGATGCAGGAGAAGAACAACACGGACTTCCTCAGCTACAACATCTGCCTC
ACTGGCTGGGATGAGTCTCAGGCCAGTCACTTTGCTATGCATCATGACGAGGAGAAAGAT
GTAATCACAGGCCTGAAACAAAAGACCTTGTATGGACGACCCAACTGGGATAACGAGTTC
AAGACCATTGGAAGTCAACATCCCAATACCAGAATAGGAGTCTTCCTCTGCGGACCGGAA
GCCTTGGCTGACACCCTTAATAAGCAGTGCATCTCCAACTCCGACTCTGGCCCCAGGGGA
GTGCATTTCATTTTCAACAAGGAAAACTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 570 |
| Molecular Weight
| 65643.0 |
| Theoretical pI
| 8.74 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 9-29
- 49-69
- 103-123
- 170-190
- 201-221
- 262-282
|
| Protein Sequence
|
>Cytochrome b-245 heavy chain
MGNWVVNEGISIFVILVWLGMNVFLFVWYYRVYDIPDKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHL
FNVEWCVNARVNNSDPYSIALSDIGDKPNETYLNFVRQRIKNPEGGLYVAVTRLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAQRIVRGQTAESLLKHQ
PRNCYQNISQWGKIENCPIPEFSGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPVVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFKACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNKAPNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQEKNNTDFLSYNICL
TGWDESQASHFAMHHDEEKDVITGLKQKTLYGRPNWDNEFKTIGSQHPNTRIGVFLCGPE
ALADTLNKQCISNSDSGPRGVHFIFNKENF
|
| External Links |
|---|
| GenBank ID Protein
| AAC27247.1 |
| UniProtKB/Swiss-Prot ID
| O46522 |
| UniProtKB/Swiss-Prot Entry Name
| CY24B_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF036097 |
| GeneCard ID
| CYBB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
