| Identification |
|---|
| BMDB Protein ID
| BMDBP01470 |
| Secondary Accession Numbers
| None |
| Name
| Transcription factor NF-E2 45 kDa subunit |
| Synonyms
|
Not Available
|
| Gene Name
| NFE2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein dimerization activity |
| Specific Function
| Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| NFE2 |
| Gene Sequence
|
>1125 bp
ATGTCCCCGTGTCCTCCACAGCAGAGCAGGAACAGGGTAACACAGCTGCCCATTCCGGAG
CCAGGTGAGATGGAACTGACTTGGCAGGAGATCATGTCCATCACTGAGCTGCAGGGTCTG
AATGCTCCAAGTGAGCCATCGTTCGAGCCCCCAGCCCCTGTCCCATACCCAGGGCCCCCA
CCGCCTCCAAGTTACTGTCCCTGCTCTATCCACTCGGAGCCTGGCTTTCCCCTTCCTGCA
CCACCTTATGAGCTCCCAGCACCCACGTCTCATGTCCCAGACCCTCCGTACTCCTATGGC
AGCAACATGACTGTACCAGTCTCCAAGCCACTGACCCTCTCGGGCCTGCTCAGTGACCCC
CTCCCAGACCCCTTGGCCCTCCTGGACATTGGGTTGTCAGCGGGGCCATCCAAGCCCCAA
GAAGACCCAGAATCTGACTCAGGATTATCCCTCAACTATAGCGACGCTGAATCTCTTGAG
TTGGAGGGGACGGAGGCTGGCCGGCGTCGCAGCGAGTATGTAGAGATGTACCCAGTGGAG
TACCCCTACTCACTAATGCCCAACTCCTTGACCCACCCCAACTATGCCTTGCCACCTGCC
GAGACCCCCTTAGCCTTAGAACCCTCCTCTGGCCCTGTGCGGGCCAAGCCCACTGCACGG
GGGGAGGCAGGGAGTCGGGATGAGCGGCGGGCCCTGGCCATGAAGATCCCCTTCCCTACG
GACAAGATTGTCAACCTGCCAGTAGACGACTTTAACGAGCTGCTGGCGCGGTACCCGCTG
ACAGAGAGCCAGCTGGCCCTGGTCCGGGACATCCGAAGGCGGGGCAAGAACAAGGTGGCT
GCCCAGAACTGTCGCAAGAGAAAGCTGGAGACCATCGTGCAGCTGGAGCGGGAACTGGAG
CGGCTGGGCAGCGAGCGGGAGCGGCTTCTCCGGGCCCGAGGCGAAGCCGACCGGACCCTA
GAGGTCATGCGCCAACAGCTGACGGACCTGTACCGTGACATTTTCCAGCACTTACGGGAT
GAAGCAGGCAACAGCTACTCCCCTGAAGACTATGCGCTACACCAGGCTGCTGATGGGGCC
ATCTTCCTGGTGCCCCGGGGGACCAAGATGGAGGCCACAGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 41390.0 |
| Theoretical pI
| 4.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transcription factor NF-E2 45 kDa subunit
MSPCPPQQSRNRVTQLPIPEPGEMELTWQEIMSITELQGLNAPSEPSFEPPAPVPYPGPP
PPPSYCPCSIHSEPGFPLPAPPYELPAPTSHVPDPPYSYGSNMTVPVSKPLTLSGLLSDP
LPDPLALLDIGLSAGPSKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVE
YPYSLMPNSLTHPNYALPPAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPT
DKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELE
RLGSERERLLRARGEADRTLEVMRQQLTDLYRDIFQHLRDEAGNSYSPEDYALHQAADGA
IFLVPRGTKMEATD
|
| External Links |
|---|
| GenBank ID Protein
| AAX08653.1 |
| UniProtKB/Swiss-Prot ID
| Q5EAD3 |
| UniProtKB/Swiss-Prot Entry Name
| NFE2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020636 |
| GeneCard ID
| NFE2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
