| Identification |
|---|
| BMDB Protein ID
| BMDBP01500 |
| Secondary Accession Numbers
| None |
| Name
| Translocator protein |
| Synonyms
|
Not Available
|
| Gene Name
| TSPO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1649835). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| TSPO |
| Gene Sequence
|
>510 bp
ATGGCCCCACCCTGGGTGCCTGCCGTGGGCTTCACGCTGTTGCCCAGTCTGGGGGGCTTC
CTGGGTGCCCAGTACACCCGCGGAGAGGGTTTCCGCTGGTACGCCAGCCTGCAGAAGCCC
CCGTGGCACCCGCCCCGCTGGATTCTGGCTCCCATCTGGGGCACACTCTACTCGGCCATG
GGGTATGGTTCCTACATGATCTGGAAAGAGCTGGGGGGCTTCTCGAAGGAGGCGGTGGTT
CCCCTGGGCCTCTACGCTGGGCAGCTGGCTCTGAACTGGGCATGGCCTCCCCTCTTCTTC
GGCACTCGACAAATGGGCTGGGCCTTGGTGGATCTCCTGCTGACTGGCGGCATGGCAGCA
GCCACGGCCATGGCCTGGCACCAGGTGAGCCCGCCGGCTGCCTGCCTGCTGTACCCGTAC
CTGGCCTGGCTGGCCTTTGCCGGCATGCTCAACTACCGCATGTGGCAGGACAACCAGGTC
CGGAGGAGTGGCCGGCGGCTCTCGGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 169 |
| Molecular Weight
| 18927.0 |
| Theoretical pI
| 9.94 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-26
- 47-67
- 80-100
- 106-126
- 135-155
|
| Protein Sequence
|
>Translocator protein
MAPPWVPAVGFTLLPSLGGFLGAQYTRGEGFRWYASLQKPPWHPPRWILAPIWGTLYSAM
GYGSYMIWKELGGFSKEAVVPLGLYAGQLALNWAWPPLFFGTRQMGWALVDLLLTGGMAA
ATAMAWHQVSPPAACLLYPYLAWLAFAGMLNYRMWQDNQVRRSGRRLSE
|
| External Links |
|---|
| GenBank ID Protein
| AAA30686.1 |
| UniProtKB/Swiss-Prot ID
| P30535 |
| UniProtKB/Swiss-Prot Entry Name
| TSPO_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M64520 |
| GeneCard ID
| TSPO |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
