<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:27:35 UTC</creation_date>
  <update_date>2020-05-20 21:07:13 UTC</update_date>
  <accession>BMDBP01571</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>SLC22A16</gene_name>
  <general_function>Carbohydrate transport and metabolism</general_function>
  <specific_function>High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000062</accession>
      <name>L-Carnitine</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>9</chromosome_location>
    <locus/>
    <gene_sequence>&gt;906 bp
ATGGGGTCCAGCAACTTGGAGCTGATTTTTGACAGCGTGGGGCACTTCGGCAGATACCAA
ATATTCCTCTATTTTATATGTGCCTTCCAAAATATCTCTTGTGGTATCCACTACTTGGCT
TCTGTGTTCTTGTCAGTGTCCCCCCAGCATACCTGTAGGCCCCCAGGCAATGTGAGTCAG
GTTCTTTTCCAAGACCTCTCTACTTGGCAGTTGGAGGACATCTGGACCCAGTTCTCCGTA
GGCCGTGAGGATCGCATTCTCGTGCAGCTGCAGGATGGGGCGATCTGGGAGCTTACCAGC
TGTCAGAGGTTCCGGAGGGATGACCAGTCGAGCCTGGACTATGAGTACAGCGGCCAGAAG
AGCAGCTTCCCTTGCTTGGATGGCTACATCTACGACAGAAGCAAGTGGCTCAGCACTGTG
GTGACCCAGTGGGACCTGGTGTGTAACCGAGAGTGGTTTGGAAGGCTGATCCAGCCCACG
TTTATGTTTGGAGTCCTGCTGGGAGCAGTGATCTTTGGCTACCTCTCCGACAGGGCAGGA
AGACGACTTGTTTTGTGGGCCTCAAGCACCGGTGTATTTTTGTTTGGCATAGCGGCGGCA
TTCACATTTGATTATTACAGCTTCATAGTCGCACGCTTTCTTCTTGCTATCTCTGGAAGT
GGCTATCTCGTGGTGGTGTTTGTCTATGTGACAGAATTTGTCGGCATGAAGTCTCGGACG
TGGGCGTCCATCCACTTGCATTCCTTTTTTTGCTTTTGGAACCATGGTGGTGGCTTTGAC
GGGCTACTTCGTCAGGACCTGGTGGATCTATCAGATAGTCCTCTCCTCCGTGACTGTCCC
CTTTGTCTTGTGCTGTTGGATGCTCCCAGAGACACCTTTTTGGCTTATCTCAGGGGGAAA
ATATGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>572</residue_number>
    <molecular_weight>64355.0</molecular_weight>
    <theoretical_pi>6.59</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>21-41</region>
      <region>156-176</region>
      <region>183-203</region>
      <region>208-228</region>
      <region>244-264</region>
      <region>268-288</region>
      <region>359-379</region>
      <region>389-409</region>
      <region>416-436</region>
      <region>441-461</region>
      <region>476-496</region>
      <region>503-523</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Solute carrier family 22 member 16
MGSSNLELIFDSVGHFGRYQIFLYFICAFQNISCGIHYLASVFLSVSPQHTCRPPGNVSQ
VLFQDLSTWQLEDIWTQFSVGREDRILVQLQDGAIWELTSCQRFRRDDQSSLDYEYSGQK
SSFPCLDGYIYDRSKWLSTVVTQWDLVCNREWFGRLIQPTFMFGVLLGAVIFGYLSDRAG
RRLVLWASSTGVFLFGIAAAFTFDYYSFIVARFLLAISGSGYLVVVFVYVTEFVGMKSRT
WASIHLHSFFAFGTMVVALTGYFVRTWWIYQIVLSSVTVPFVLCCWMLPETPFWLISGGK
YEEAQKVIDTMAKWNRTRPCKLSEILSLDHDGSAGNKPSQVEKHTLSELFYDWSIGTRTL
ILWLIWFTGCLGFYTFSLNSVHLGGSEYLNLFLMGVVEIPAYVLVCLGMDRVGRRNILIF
SLLSSAVTSGVIMVIPKDYHVWLVVASMAGKFFIGAAFGLIYLYTAELYPTIVRSLAVGS
GSTVGRVGSIVAPLCIYLSSVWIFMPQLLVGTLALVSGVLTFLLPETLRRPLTTTWEETE
KESSSGKLLSTTSNTVLENVTVENSEDSSLNK</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI18254.1</genbank_protein_id>
  <uniprot_id>Q17QN9</uniprot_id>
  <uniprot_name>S22AG_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC118253</genbank_gene_id>
  <genecard_id>SLC22A16</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
