| Identification |
|---|
| BMDB Protein ID
| BMDBP01589 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic AMP-responsive element-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CREB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein dimerization activity |
| Specific Function
| Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| CREB1 |
| Gene Sequence
|
>978 bp
ATGGAATCTGGAGCAGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCTGAAAGC
CAGCAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCTATGCCA
GCAGCTCACGCAACATCATCTGCTCCCACCGTAACTTTAGTACAGCTGCCCAATGGGACC
AAGGTTCAAGTCCATGGAGTTATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAA
GTCCAGACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCAGTGGAT
AGTGTAACCGATTCCCAAAAACGAAGAGAGATTCTTTCAAGGAGGCCTTCCTACAGGAAA
ATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAGAAATCT
GAAGAGGAGACTTCAGCACCTGCCATCACCACTGTCACGGTGCCAACTCCGATTTATCAG
ACTAGCAGTGGACAGTATATTGCCATTACCCAAGGAGGAGCAATACAACTGGCTAACAAT
GGTACTGATGGGGTACAGGGCCTGCAGACATTAACCATGACCAATGCAGCTGCCACTCAG
CCAGGTACTACCATCCTGCAGTATGCACAGACCACTGATGGACAGCAAATCCTAGTGCCC
AGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGATGTACAGACATACCAGATTCGCACA
GCGCCCACTAGCACCATTGCCCCTGGAGTTGTTATGGCGTCTTCCCCAGCACTTCCTACA
CAGCCTGCTGAAGAAGCGGCGCGAAAGAGAGAGGTTCGCCTCATGAAGAACAGGGAAGCA
GCACGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTCTAGAAAACAGAGTGGCA
GTGCTTGAAAATCAAAACAAGACACTGATTGAGGAGCTAAAAGCACTTAAGGACCTTTAC
TGCCACAAATCAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 325 |
| Molecular Weight
| 34877.0 |
| Theoretical pI
| 4.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-25
- 46-67
- 82-102
- 109-127
- 147-169
- 198-215
- 257-277
|
| Protein Sequence
|
>Cyclic AMP-responsive element-binding protein 1
MESGAENQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQ
TVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRK
ILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANN
GTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRT
APTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVA
VLENQNKTLIEELKALKDLYCHKSD
|
| External Links |
|---|
| GenBank ID Protein
| CAA40347.1 |
| UniProtKB/Swiss-Prot ID
| P27925 |
| UniProtKB/Swiss-Prot Entry Name
| CREB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X57031 |
| GeneCard ID
| CREB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
