| Identification |
|---|
| BMDB Protein ID
| BMDBP01596 |
| Secondary Accession Numbers
| None |
| Name
| Rho-related GTP-binding protein RhoU |
| Synonyms
|
Not Available
|
| Gene Name
| RHOU |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| RHOU |
| Gene Sequence
|
>768 bp
ATGCCCCCGCAGCAGGGGGACCCCGCGTTCCCGGGCCGCTGCGAGGCGCCGCCCGTGCCG
CCCCGCCGGGAGCGCGGGGTCCGTGGGCCCGGGGCGCCGGGGGGCCGGGGGCGCGCGGGC
GGCCCCGAGGGGCACGGCGTCAAGTGCGTGCTGGTCGGCGACGGCGCCGTGGGCAAGACC
AGCTTGGTGGTGAGCTACACCACCAACGGCTACCCCACCGAGTACATCCCCACCGCCTTC
GACAACTTCTCGGCTGTGGTTTCCGTGGATGGGCGGCCCGTGAAACTCCAGCTCTGTGAC
ACTGCAGGACAGGATGAGTTTGACAAGCTCCGGCCTCTGTGCTACACCAATGCCGACATC
TTCCTCCTGTGCTTCAGTGTTGTGGGTCCCTCCTCCTTCCAGAACGTCAGTGAGAAATGG
GTGCCAGAGATTCGGTGCCACTGTCCCAAAGCCCCCATCATCCTCGTGGGGACACAGTCG
GACCTCAGAGAAGACGTCAAAGTCCTCATCGAGCTGGACAAATGCAAAGAGAAGCCGGTA
CCCGAGGAGGCGGCCAGGTTGTGTGCCGAGGAGATCAAAGCCACCTCTTACATTGAGTGC
TCGGCCTTGACTCAGAAGAACCTCAAAGAGGTCTTCGATGCAGCCATTGTAGCCGGCATT
CAGTATTCAGACTCCCAGCAGCAGCCAAAGAAGTCCAAGAGCAGGACTCCCGACAAGATG
AAGACCTTATCCAAGTCCTGGTGGAAGAAGTACTGCTGTTTCGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 255 |
| Molecular Weight
| 27824.0 |
| Theoretical pI
| 8.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 30-56
- 77-98
- 113-133
- 140-158
- 178-200
- 229-246
- 288-307
- 319-338
- 350-372
|
| Protein Sequence
|
>Rho-related GTP-binding protein RhoU
MPPQQGDPAFPGRCEAPPVPPRRERGVRGPGAPGGRGRAGGPEGHGVKCVLVGDGAVGKT
SLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVKLQLCDTAGQDEFDKLRPLCYTNADI
FLLCFSVVGPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPV
PEEAARLCAEEIKATSYIECSALTQKNLKEVFDAAIVAGIQYSDSQQQPKKSKSRTPDKM
KTLSKSWWKKYCCFV
|
| External Links |
|---|
| GenBank ID Protein
| AAI40581.1 |
| UniProtKB/Swiss-Prot ID
| A5D7J5 |
| UniProtKB/Swiss-Prot Entry Name
| RHOU_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC140580 |
| GeneCard ID
| RHOU |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
