| Identification |
|---|
| BMDB Protein ID
| BMDBP01599 |
| Secondary Accession Numbers
| None |
| Name
| Transforming protein RhoA |
| Synonyms
|
Not Available
|
| Gene Name
| RHOA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. May be an activator of PLCE1 (By similarity). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| RHOA |
| Gene Sequence
|
>582 bp
ATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGAGATGGAGCCTGTGGCAAGACTTGC
TTGCTCATTGTCTTTAGCAAGGACCAGTTCCCAGAGGTGTATGTCCCTACGGTGTTTGAG
AACTATGTGGCAGATATTGAAGTGGATGGAAAGCAGGTAGAGTTGGCTTTATGGGACACA
GCTGGGCAGGAAGATTATGATCGCTTGAGGCCTCTCTCCTACCCGGATACCGACGTTATA
CTGATGTGTTTCTCCATTGATAGCCCTGATAGTTTAGAAAACATACCAGAAAAATGGACT
CCGGAAGTCAAGCATTTCTGTCCCAACGTGCCCATCATCCTGGTTGGGAACAAGAAGGAT
CTTCGAAACGACGAGCACACAAGGCGGGAGCTGGCCAAGATGAAGCAGGAGCCAGTAAAA
CCCGAAGAAGGCAGAGATATGGCAAACAGGATTGGTGCTTTTGGGTACATGGAGTGTTCA
GCAAAGACCAAAGATGGAGTGAGGGAGGTTTTTGAAATGGCCACGAGAGCTGCTCTGCAA
GCCAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 193 |
| Molecular Weight
| 21768.0 |
| Theoretical pI
| 5.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transforming protein RhoA
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ
ARRGKKKSGCLVL
|
| External Links |
|---|
| GenBank ID Protein
| AAA30409.1 |
| UniProtKB/Swiss-Prot ID
| P61585 |
| UniProtKB/Swiss-Prot Entry Name
| RHOA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M27278 |
| GeneCard ID
| RHOA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
