| Identification |
|---|
| BMDB Protein ID
| BMDBP01602 |
| Secondary Accession Numbers
| None |
| Name
| Integrin alpha-L |
| Synonyms
|
Not Available
|
| Gene Name
| ITGAL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| ITGAL |
| Gene Sequence
|
>3498 bp
ATGAATTCCTGCATCATCGTGCTGAGGTTGCTGCTGTCTGGACCTTTTGTCTTTGCCCCA
GCCTGGAGCTACAACCTGGATGTGCGACATGTGCAAAACTTCTCCTTTCCACTTGCCGGG
AGGCATTTTGGGTACCGCGTTCTGCAAGTTGGAAATGGGGTTGTCGTGGGAGCTCCAAGC
GAAGGGAACAGCATGGGAAACCTGTATCAATGCCAGCCAGAAACTGGAGACTGCCTGCCA
GTCACACTGAGTTCCAACTATACCTCCAAGTACTTGGGAATGACCTTGGCAACAGACCCC
ACAAGTGACAACCTGTTGGCCTGTGATCCTGGGCTGTCTCGAACATGTGACCAGAACATC
TATCTAAGTGGTCTGTGTTACCTCATCCACGAGAACCTGAGGGGTCCGGTGCTGCAAGGG
CACCCTGGTTATCAGGAATGTATAAAGGGCAACGTAGACTTGGTATTTCTGTTTGATGGC
TCAATGAGCTTGCAGCAAGATGAATTTGAGAAAATTGTGGACTTCATGAAGGATGTGATG
AAGAAACTCAGCAACTCTTCCTACCAGTTTGCGGCTGTTCAGTTTTCTACATATTTCAGA
ACAGAATTTACTTTCTTGGATTACATTAGACAGAAGGACCCTGACGCTCTGTTGGCTGGA
GTCAAACACATGCGTTTGTTGACCAACACCTTTGGTGCCATCAACTATGTTGCGAAAGAA
GTGTTCCGGCCAGACCTGGGAGCCCGCCCAGATGCCACCAAAGTGCTTATCATCATCACT
GATGGGGAAGCCACCGACGAACACAACATTGATGCGGCCAAAGACATCATCCGCTACATC
ATTGGGATTGGAAAAAATTTTAAGACCAAAGAAAGTCAGGAGGCGCTCCATCAGTTTGCC
TCCAAACCCGTGGAGGAGTTTGTAAAGATCCTGGACACGTTTGAGAAGCTGAAAGATCTA
TTCACCGAGCTGCAAAAAAAGATCTATGTCATTGAGGGCACAAGCAAACAGGACCTGACA
TCCTTCAACATGGAGCTGTCCTCCAGCGGGATCAGCGCGGACCTCAGCGAGGGCCATGGC
GTTGTGGGGGCCGTTGGAGCCAAGGACTGGGCTGGGGGCTTTCTCGACCTGAAGGCAGAC
CTGAAAAGCAGTACATTTGTTGGCAATGAACCACTGACAGTAGAATCGAGGGCAGGATAT
TTGGGTTACACGGTGACCTGGCTGCCCTCCCGAGGGACCATGTCATTGCTGGCCACTGGA
GCCCCCAGATACCAGCATGTCGGGCGGGTGCTGCTGTTCCAACAGCCAAAGAGAGGAGGA
CCCTGGAGCCAGATCCAGGAAATAGATGGGATCCAGATTGGCTCTTATTTTGGTGGCGAG
TTGTGTGGCGTTGACGTGGACAGAGATGGGGAGACGGAGCTGTTGCTGATTGCAGCCCCC
CTGTACTATGGGGAGCAGAGAGGAGGCCGGGTGTTTATCTACCAGAAAATACAGCTGGAG
TTCCAAATGGTCTCAGAGCTGCAGGGGGAGACCGGCTACCCCCTTGGGCGATTTGGAGCT
GCCATCGCTGCCCTGACAGACATCAACGGGGATGAGCTGACAGACGTGGCTGTGGGAGCC
CCTCTGGAGGAGCAGGGGGCCGTGTACATCTTCAATGGGCAACAAGGGGGGCTGAGCCCC
CGGCCCAGTCAGCGGATAGAAGGGACCCAGATGTTCTCAGGAATTCAATGGTTTGGACGC
TCCATCCACGGGGTGAAGGACCTCGGCGGGGATGGCCTGGCAGATGTGGCTGTGGGGGCT
GAGGGCCAGGTGATCGTGCTCAGCTCCCGGCCTGTGGTGGACATCATCACAAGCGTGTCC
TTCTCCCCGGCCGAGATCCCAGTGCATGAAGTCGAGTGCTCCTATTCCACCAGCAACCAG
AAGAAGGAAGGCGTTAACCTCACAGTCTGTTTCCAGGTCAAGTCTCTCATCTCCACCTTC
CAAGGGCACCTGGTTGCCAACCTCACTTACACTCTGCAGCTGGATGGCCATCGGACCCGA
AGCCGGGGCTTGTTCCCAGGAGGGAAACACAAACTCATCGGGAACACAGCTGTCACCCCT
GTCAAGTCCTGCTTTGTGTTCTGGTTCCACTTCCCGATATGCATTCAAGATCTCATCTCT
CCCATCAACGTCTCCCTAAGTTACTCTCTCTGGGAGGAAGAAGGGACACCGAGGGACCCA
AGGGCGCTGGACAGGGACATCCCGCCCATCCTGAAACCCTCACCACACTTGGAGACCAAG
GAGATTCCTTTTGAGAAGAACTGCGGAGAGGACAAGAATTGTGAGGCAGACCTGAAGCTG
GCCTTCTCCGACATGAGATCCAAAATCCTGCGTCTGACCCCCTCTGCCAGCCTCTCTGTG
AGGCTGACACTGAGGAACACAGCAGAAGATGCTTACTGGGTCCAGGTCACCCTGAGCTTC
CCCCAGGGACTCTCATTCCGCAAAGTGGAGATCCTCAAGCCCCACAGCCATGTACCTGTG
GGCTGCGAGGAGCTCCCTGAGGAGGCCGTAGTGCACAGCAGGGCCCTCTCCTGCAATGTG
AGCTCTCCCATCTTCGGAGAAGACAGCATGGTTGATATCCAGGTGATGTTTAATACGCTG
CAGAAAGGCTCCTGGGGGGATTTTATCGAGCTGCAGGCCAATGTGAGCTGCAACAATGAG
GACTCAAGCCTCCTGGAGGACAACTCGGCCACCACCAGCATCCCTGTCATGTACCCCATC
AACGTCCTCACCAAGGACCAGGAAAACTCCACGCTGTATATCAGTTTCACCCCCAAGAGT
CCCAAGATCCACCATGTCAAGCACATTTACCAGGTGAGGATCCAGCCTTCTAACTATGAC
AACATGCCCCCACTGGAGGCCTTGGTTAGGGTACCACGGGTGCACAGCGAGGGGCTCATC
ACCCACAAGTGGAGCATACAGATGGAGCCTCCAGTCAACTGCAGCCCCAGAAATCTGGAG
AGTCCATCTGATGAGGCTGAGTCTTGCTCGTTTGGAACCGAGTTCCGCTGCCCAATTGAC
TTCAGACAGGAGATCCTTGTCCAAGTGAACGGGATGGTGGAGTTGAGGGGGACGATCAAG
GCCTCCTCCATGTTGAGCCTCTGTAGCTCCCTCGCTATCTCCTTCAACAGCAGCAAGCAT
TTTCACCTCTATGGCAGGAACGCCTCCATGGCCCAGGTCGTCATGAAGGTTGACCTTGTA
TATGAGAAAGAGATGCTCTATCTCTACGTGCTGAGCGGAATCGGGGGGCTGTTGTTGCTG
TTCCTGATTTTCATAGCTCTGTACAAGGTTGGTTTCTTCAAACGGAACCTGAAGGAGAAG
ATGGAGGCGAACGTAGATGCTTCCAGTGAAATCCCTGGAGAAGATGCTGGGCAGCCGGAG
TTGGAGAAAGAGTGCAAGGACCCAGGCTGCCTGGAGCCCCTCCAGAAGACGGATGAGGAC
GGAAGTGGTGGAGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1165 |
| Molecular Weight
| 128726.0 |
| Theoretical pI
| 5.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Integrin alpha-L
MNSCIIVLRLLLSGPFVFAPAWSYNLDVRHVQNFSFPLAGRHFGYRVLQVGNGVVVGAPS
EGNSMGNLYQCQPETGDCLPVTLSSNYTSKYLGMTLATDPTSDNLLACDPGLSRTCDQNI
YLSGLCYLIHENLRGPVLQGHPGYQECIKGNVDLVFLFDGSMSLQQDEFEKIVDFMKDVM
KKLSNSSYQFAAVQFSTYFRTEFTFLDYIRQKDPDALLAGVKHMRLLTNTFGAINYVAKE
VFRPDLGARPDATKVLIIITDGEATDEHNIDAAKDIIRYIIGIGKNFKTKESQEALHQFA
SKPVEEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSEGHG
VVGAVGAKDWAGGFLDLKADLKSSTFVGNEPLTVESRAGYLGYTVTWLPSRGTMSLLATG
APRYQHVGRVLLFQQPKRGGPWSQIQEIDGIQIGSYFGGELCGVDVDRDGETELLLIAAP
LYYGEQRGGRVFIYQKIQLEFQMVSELQGETGYPLGRFGAAIAALTDINGDELTDVAVGA
PLEEQGAVYIFNGQQGGLSPRPSQRIEGTQMFSGIQWFGRSIHGVKDLGGDGLADVAVGA
EGQVIVLSSRPVVDIITSVSFSPAEIPVHEVECSYSTSNQKKEGVNLTVCFQVKSLISTF
QGHLVANLTYTLQLDGHRTRSRGLFPGGKHKLIGNTAVTPVKSCFVFWFHFPICIQDLIS
PINVSLSYSLWEEEGTPRDPRALDRDIPPILKPSPHLETKEIPFEKNCGEDKNCEADLKL
AFSDMRSKILRLTPSASLSVRLTLRNTAEDAYWVQVTLSFPQGLSFRKVEILKPHSHVPV
GCEELPEEAVVHSRALSCNVSSPIFGEDSMVDIQVMFNTLQKGSWGDFIELQANVSCNNE
DSSLLEDNSATTSIPVMYPINVLTKDQENSTLYISFTPKSPKIHHVKHIYQVRIQPSNYD
NMPPLEALVRVPRVHSEGLITHKWSIQMEPPVNCSPRNLESPSDEAESCSFGTEFRCPID
FRQEILVQVNGMVELRGTIKASSMLSLCSSLAISFNSSKHFHLYGRNASMAQVVMKVDLV
YEKEMLYLYVLSGIGGLLLLFLIFIALYKVGFFKRNLKEKMEANVDASSEIPGEDAGQPE
LEKECKDPGCLEPLQKTDEDGSGGD
|
| External Links |
|---|
| GenBank ID Protein
| AAP94035.1 |
| UniProtKB/Swiss-Prot ID
| P61625 |
| UniProtKB/Swiss-Prot Entry Name
| ITAL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY267467 |
| GeneCard ID
| ITGAL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
