| Identification |
|---|
| BMDB Protein ID
| BMDBP01703 |
| Secondary Accession Numbers
| None |
| Name
| Zinc finger and BTB domain-containing protein 18 |
| Synonyms
|
Not Available
|
| Gene Name
| ZBTB18 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleic acid binding |
| Specific Function
| Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| ZBTB18 |
| Gene Sequence
|
>1596 bp
ATGTGTCCTAAAGGTTATGAAGACAGTATGGAGTTTCCAGACCATAGTAGACATTTGCTG
CAGTGTCTGAGCGAGCAGAGACATCAGGGTTTTCTTTGTGACTGCACTGTTCTGGTGGGA
GATGCCCAGTTCCGAGCGCACCGAGCTGTACTGGCTTCATGCAGCATGTATTTCCACCTC
TTTTACAAGGACCAGCTGGACAAAAGAGACATTGTTCATCTGAACAGCGACATTGTTACA
GCCCCAGCCTTCGCTCTCCTGCTTGAATTCATGTATGAAGGGAAACTCCAGTTCAAAGAC
TTGCCCATTGAAGACGTGCTAGCAGCTGCCAGTTATCTCCACATGTATGACATTGTCAAA
GTCTGCAAAAAGAAGCTGAAAGAGAAAGCCACCACGGAGGCAGACAGCACCAAAAAGGAA
GAAGATGCTTCAAGTTGTTCGGACAAAGTCGAGAGCCTCTCGGATGGCAGCAGCCACATG
GCAGGCGATTTGCCCAGTGATGAAGATGAAGGGGAAGATGAAAAACTGAACATCTTGCCC
AGCAAAAGGGACTTGGCGGCCGAGCCTGGGAACATGTGGATGCGATTGCCCTCGGACTCA
GCAGGCATCCCCCAGGCTGGCGGAGAGGCAGAGCCACACGCCACAGCAGCTGGAAAAACA
GTAGCCAGCCCCTGCAGCTCAACAGAGTCTTTGTCCCAGAGGTCTGTCACCTCCGTGAGG
GATTCGGCAGATGTTGACTGTGTGCTGGACCTGTCTGTCAAGTCCAGCCTTTCAGGAGTT
GAAAATCTGAACAGCTCTTATTTCTCTTCACAGGACGTGCTGAGAAGCAACCTGGTGCAG
GTGAAGGTGGAGAAAGAGGCTTCCTGTGATGAGAGTGATGTTGGCACTAATGACTATGAC
ATGGAACATAGCACTGTGAAAGAGAGTGTGAGCACTAATAACAGGGTACAGTATGAGCCG
GCCCATCTGGCTCCTCTGAGGGAGGACTCGGTCCTGAGGGAGCTGGAGCGGGAGGACAAA
GCCAGCGACGACGAGATGATGACCCCCGAGAGCGAGCGGGTCCAGGTGGAGGGCGGCATG
GAGAGCAGCCTGCTGCCCTACGTCTCCAACATCCTGAGCCCGGCCGGCCAGATCTTCATG
TGCCCCCTGTGCAACAAGGTCTTCCCCAGCCCGCACATCCTGCAGATCCACCTGAGCACG
CACTTCCGCGAGCAGGACGGCCTGCGCAGCAAGCCGGCCGCCGACGTCAACGTGCCCACC
TGCTCGCTGTGCGGGAAGACGTTCTCCTGCATGTACACCCTGAAGCGCCACGAGAGGACT
CACTCGGGCGAGAAGCCCTACACGTGCACGCAGTGCGGCAAGAGCTTCCAGTACTCGCAC
AACCTGAGCCGCCACGCCGTGGTGCACACGCGCGAGAAGCCGCACGCCTGCAAGTGGTGC
GAGCGCAGGTTCACGCAGTCCGGGGACCTGTACCGGCATATCCGCAAGTTCCACTGTGAG
TTGGTGAACTCCTTGTCGGTCAAAAGCGAGGCGCTGAGCCTGCCCGCGGTCAGAGACTGG
ACCTTAGAAGATAGCTCTCAAGAACTCTGGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 522 |
| Molecular Weight
| 58356.0 |
| Theoretical pI
| 5.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Zinc finger protein 238
MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHL
FYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVK
VCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHMAGDLPSDEDEGEDEKLNILP
SKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVR
DSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYD
MEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELEREDKASDDEMMTPESERVQVEGGM
ESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGLRSKPAADVNVPT
CSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWC
ERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPAVRDWTLEDSSQELWK
|
| External Links |
|---|
| GenBank ID Protein
| AAI26551.1 |
| UniProtKB/Swiss-Prot ID
| A0JN76 |
| UniProtKB/Swiss-Prot Entry Name
| ZBT18_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126550 |
| GeneCard ID
| ZBTB18 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
