| Identification |
|---|
| BMDB Protein ID
| BMDBP01811 |
| Secondary Accession Numbers
| None |
| Name
| Synaptic vesicular amine transporter |
| Synonyms
|
Not Available
|
| Gene Name
| SLC18A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| SLC18A2 |
| Gene Sequence
|
>1554 bp
ATGGCCCTGAGCGAGCTGGCGCTGCTCCGCCGGCTTCAGGAGAGCCGGCACTCGCGGAAG
CTCATCCTGTTCATCGTGTTCCTCGCGCTGCTGCTGGACAACATGCTGCTCACGGTTGTG
GTCCCCATCATCCCGAGTTACTTGTACAGCATTGAGCATGAGAAAGATGCTCTAGAAATC
CAGACCGCCAAGCCCGGGCTCACAGCCTCCGCCCCCGGGAGCTTCCAGAACATCTTCTCC
TATTATGACAACTCCACCATGGTCACCGGGAACAGCACCGACCACCTTCAGGGGGCGCTG
GTGCATGAGGCCACCACGCAGCACATGGCCACTAACTCGTCCTCGGCCTCTTCCGACTGT
CCCAGTGAAGACAAAGACCTCCTGAATGAGAATGTGCAGGTCGGGCTGCTGTTTGCCTCG
AAAGCCACTGTCCAGCTCCTCACCAACCCGTTCATAGGACTGTTGACCAACAGAATTGGC
TACCCAATTCCCATGTTTACGGGATTCTGCATCATGTTTATCTCAACAGTTATGTTCGCC
TTCTCCCGCACGTACGCCTTCCTGCTGATCGCCAGGTCCCTGCAGGGCATCGGTTCCTCC
TGCTCATCTGTAGCTGGCATGGGCATGCTGGCCAGCGTGTACACAGATGACGAGGAGAGG
GGCAACGCCATGGGGATCGCCCTGGGAGGCCTGGCCATGGGGGTCCTAGTGGGCCCCCCC
TTTGGGAGTGTGCTGTACGAGTTTGTGGGGAAGACAGCTCCGTTCCTGGTCTTGGCTGCC
CTGGTGCTCTTGGATGGAGCCATTCAGCTCTTTGTGCTCCAGCCGTCCCGGGTACAGCCA
GAGAGCCAGAAGGGGACGCCGCTCACCACCCTGCTGAGGGACCCATACATCCTCATCGCT
GCAGGGTCCATCTGCTTCGCAAACATGGGGATTGCCATGCTGGAGCCAGCCCTGCCCATC
TGGATGATGGAGACCATGTGTTCCCACAAGTGGCAGCTGGGCGTGGCTTTCTTGCCAGCT
AGCGTCTCTTATCTCATTGGAACCAATGTTTTTGGGATCCTCGCACACAAAATGGGGAGA
TGGCTTTGTGCTCTTCTAGGAATGATAATTGTCGGAATGAGCATTTTATGTATTCCTCTT
GCAAAAAACATCTACGGACTCATAGCTCCCAACTTTGGAGTTGGTTTTGCAATTGGCATG
GTGGATTCATCAATGATGCCCATCATGGGCTACCTGGTCGACCTGCGGCACGTGTCGGTC
TATGGGAGCGTGTACGCCATTGCCGATGTTGCGTTTTGTATGGGATATGCCATAGGTCCT
TCTGCTGGTGGGGCTATCGCAAAGGCAATTGGATTTCCATGGCTCATGACAATTATTGGA
ATAATTGATATTCTTTTTGCTCCTCTCTGCTTTTTTCTTCGAAGTCCACCTGCCAAGGAA
GAAAAAATGGCTATCCTCATGGATCACAACTGCCCCATTAAAACAAAAATGTACACGCAG
AACAGCAGCCAGTCGCATCCGATAGGTGAGGATGAAGAATCTGAAAGTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 517 |
| Molecular Weight
| 55756.0 |
| Theoretical pI
| 5.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 21-41
- 133-153
- 163-183
- 193-213
- 223-245
- 252-274
- 295-314
- 332-355
- 361-381
- 393-413
- 418-438
- 444-465
|
| Protein Sequence
|
>Synaptic vesicular amine transporter
MALSELALLRRLQESRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIEHEKDALEI
QTAKPGLTASAPGSFQNIFSYYDNSTMVTGNSTDHLQGALVHEATTQHMATNSSSASSDC
PSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFTGFCIMFISTVMFA
FSRTYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPP
FGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLRDPYILIA
AGSICFANMGIAMLEPALPIWMMETMCSHKWQLGVAFLPASVSYLIGTNVFGILAHKMGR
WLCALLGMIIVGMSILCIPLAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSV
YGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKE
EKMAILMDHNCPIKTKMYTQNSSQSHPIGEDEESESD
|
| External Links |
|---|
| GenBank ID Protein
| AAA18333.1 |
| UniProtKB/Swiss-Prot ID
| Q27963 |
| UniProtKB/Swiss-Prot Entry Name
| VMAT2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U02876 |
| GeneCard ID
| SLC18A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
