| Identification |
|---|
| BMDB Protein ID
| BMDBP01813 |
| Secondary Accession Numbers
| None |
| Name
| Histamine H1 receptor |
| Synonyms
|
Not Available
|
| Gene Name
| HRH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histamine receptor activity |
| Specific Function
| In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. |
| Pathways
|
- Histamine H1 Receptor Activation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| HRH1 |
| Gene Sequence
|
>1476 bp
ATGACCTGTCCCAACTCCTCCTGCGTCTTCGAAGACAAGATGTGTCAGGGGAATAAGACT
GCCCCTGCCAACGATGCCCAGCTGACGCCCCTGGTGGTGGTCCTGAGCACCATCTCCTTG
GTCACAGTGGGACTCAACCTGCTGGTCCTGTATGCTGTGCGCAGCGAGCGGAAACTACAC
ACCGTGGGGAACCTCTACATCGTCAGCCTCTCAGTGGCCGACCTGATCGTGGGGGTGGTC
GTCATGCCCATGAACATCCTCTACCTCCTCATGTCTAGGTGGTCCCTGGGGCGTCCTCTC
TGCCTCTTCTGGCTTTCCATGGACTATGTGGCCAGCACGGCATCCATTTTCAGCGTCTTC
ATCTTGTGCATTGACCGCTACCGTTCTGTGCAGCAGCCCCTCAAGTACCTGCGGTATCGT
ACCAAGACCCGAGCATCCATCACCATCCTAGCCGCCTGGTTTCTCTCCTTCCTGTGGATT
ATCCCCATTCTGGGCTGGCGTCACTTCCAGCCAAAGACCCCAGAGCCCCGGGAGGACAAG
TGTGAGACGGACTTCTACAACGTCACGTGGTTCAAAGTCATGACCGCCATCATCAACTTC
TACTTGCCCACCTTGCTCATGCTCTGGTTCTATGCCAAGATCTACAAGGCTGTGCGGCAG
CACTGCCAGCACCGGGAGCTCATCAACGGGTCCTTCCCCTCCTTCTCTGACATGAAGATG
AAGCCGGAGAACCTCCAGGTGGGCGCTAAGAAACCGGGGAAGGAGTCCCCCTGGGAGGTT
CTGAAAAGGAAGCCAAAAGACACCGGGGGTGGACCTGTCTTGAAGCCACCATCTCAAGAG
CCAAAAGAGGTGACATCTCCAGGTGTCTTCAGCCAAGAGAAGGAAGAGAAGGATGGAGAA
CTGGGCAAATTCTACTGCTTCCCGCTTGACACTGTGCAGGCGCAGCCGGAGGCAGAGGGG
AGTGGCAGGGGCTACGCAACCATCAACCAGAGCCAGAACCAGCTTGAGATGGGTGAGCAG
GGCCTGAGCATGCCTGGGGCTAAGGAGGCCTTAGAGGATCAGATCCTAGGTGACAGCCAG
TCCTTCTCCCGGACAGACTCGGACACCCCCGCAGAGCCGGCACCAGCGAAAGGCAAGTCG
CGAAGCGAGTCTAGCACAGGCCTGGAGTACATCAAGTTCACTTGGAAGAGGCTCCGCTCG
CATTCGAGACAGTACGTGTCTGGCTTGCACATGAACCGAGAGCGGAAGGCCGCCAAGCAG
TTGGGTTTTATCATGGCGGCCTTCATCATCTGCTGGATTCCTTACTTCATCTTCTTCATG
GTCATTGCCTTCTGTGAGAGCTGCTGCAACCAGCATGTGCACATGTTCACCATCTGGCTG
GGCTACATCAACTCCACGCTGAACCCCCTCATCTACCCCTTGTGCAATGAGAACTTCAAG
AAGACCTTCAAGAAAATTCTGCACATTCGTTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 491 |
| Molecular Weight
| 55957.0 |
| Theoretical pI
| 9.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 31-53
- 64-84
- 103-124
- 145-165
- 191-211
- 421-442
- 455-474
|
| Protein Sequence
|
>Histamine H1 receptor
MTCPNSSCVFEDKMCQGNKTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLH
TVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVF
ILCIDRYRSVQQPLKYLRYRTKTRASITILAAWFLSFLWIIPILGWRHFQPKTPEPREDK
CETDFYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINGSFPSFSDMKM
KPENLQVGAKKPGKESPWEVLKRKPKDTGGGPVLKPPSQEPKEVTSPGVFSQEKEEKDGE
LGKFYCFPLDTVQAQPEAEGSGRGYATINQSQNQLEMGEQGLSMPGAKEALEDQILGDSQ
SFSRTDSDTPAEPAPAKGKSRSESSTGLEYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQ
LGFIMAAFIICWIPYFIFFMVIAFCESCCNQHVHMFTIWLGYINSTLNPLIYPLCNENFK
KTFKKILHIRS
|
| External Links |
|---|
| GenBank ID Protein
| BAA01045.1 |
| UniProtKB/Swiss-Prot ID
| P30546 |
| UniProtKB/Swiss-Prot Entry Name
| HRH1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D10197 |
| GeneCard ID
| HRH1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
