| Identification |
|---|
| BMDB Protein ID
| BMDBP01820 |
| Secondary Accession Numbers
| None |
| Name
| Muscarinic acetylcholine receptor M3 |
| Synonyms
|
Not Available
|
| Gene Name
| CHRM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in muscarinic acetylcholine receptor activity |
| Specific Function
| The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| Pathways
|
- G-Protein Signaling Through Tubby Proteins
- Gastric Acid Production
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| CHRM3 |
| Gene Sequence
|
>1773 bp
ATGACCTTGCACAATAACAATACAACCTCACCCTTGTTTCCGAACATCAGCTCTTCCTGG
ATTCACGGCCCTTCGGATACAGGGCTGCCCCCAGGAACAGTTACTCATTTTGGCAGCTAC
AACATTTCTCGGGCAGCTGGGAATCTCTCCTCTCCAAATGGCACCACCAGTGACCCTCTA
GGAGGTCATACCATCTGGCAGGTGGTCTTCATTGCATTCTTAACAGGCGTCCTGGCCTTG
GTGACCATCATTGGCAACATCCTGGTGATAGTGGCATTCAAGGTCAACAAGCAGCTGAAG
ACAGTCAACAACTACTTCCTCTTAAGTCTGGCCTGTGCTGACCTGATTATTGGGGTCATT
TCGATGAATCTGTTTACTACCTACATCATCATGAACCGATGGGCGTTGGGGAACCTGGCC
TGTGACCTCTGGCTATCCATTGACTACGTGGCTAGCAATGCCTCCGTCATGAACCTTCTG
GTCATCAGCTTCGACAGATACTTTTCCATCACGAGGCCGCTCACGTACCGAGCCAAACGA
ACAACAAAGCGAGCTGGTGTGATGATAGGTTTGGCTTGGGTCATCTCCTTCATCCTTTGG
GCTCCTGCCATCTTGTTCTGGCAATACTTTGTTGGGAAGAGAACTGTGCCTCCAGGGGAG
TGCTTCATCCAGTTCCTCAGCGAGCCCACCATAACCTTCGGAACGGCCATTGCTGCCTTT
TATATGCCTGTCACCATCATGACTATTTTATACTGGAGGATCTATAAGGAAACTGAAAAA
CGTACCAAAGAACTTGCTGGGCTGCAAGCCTCTGGAACAGAGGCCGAAGCGGAGAACTTT
GTCCACCCCACGGGCAGTTCTCGAAGCTGCAGCAGCTATGAGCTCCAGCAGCAGAGCATG
AAACGCTCAGCCAGGAGGAAGTACGGACGCTGCCATTTCTGGTTCACGACCAAGAGTTGG
AAGCCAAGCGCCGAGCAGATGGACCAAGACCACAGCAGCAGTGACAGCTGGAATAACAAT
GATGCCGCTGCCTCCCTGGAGAACTCCGCCTCCTCCGACGAGGAGGACATTGGCTCAGAG
ACCAGAGCCATCTACTCCATCGTGCTCAAGCTCCCAGGTCACAGCACCATCCTCAACTCC
ACCAAACTACCTTCATCAGACAACCTGCAGGTGCCGGAGGAGGAGCTGGGTTCAGTGGGC
TTGGAGAGGAAACCCAGCAAACTTCAGACCCAGCAGAGCATGGACGATGGAGGCAGCTTT
CAGAAAAGCTTCTCCAAGCTTCCCATCCAGTTAGAGTCTGCCGTGGACACAGCCAAGGCC
TCTGATGTCAACTCCTCGGTGGGGAAGACCACGGCCACTCTACCTCTATCCTTTAAGGAA
GCTACACTGGCCAAGAGGTTTGCTCTGAAGACCAGAAGCCAGATCACTAAGCGGAAACGG
ATGTCCCTCATCAAGGAGAAGAAAGCGGCCCAGACCCTCAGCGCCATCCTGCTTGCCTTC
ATCATCACCTGGACCCCCTACAATATCATGGTTCTAGTGAACACCTTTTGTGACAGCTGC
ATCCCCAAAACCTATTGGAATCTGGGCTACTGGCTGTGCTACATCAACAGCACCGTGAAC
CCCGTGTGCTATGCCCTGTGCAACAAAACATTCAGAAACACTTTCAAGATGCTGCTGTTG
TGTCAGTGTGACAAGAGGAAGAGACGCAAGCAGCAGTACCAGCAGAGACAGTCGGTCATT
TTCCACAAGCGGGTGCCTGAGCAGGCCTTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 590 |
| Molecular Weight
| 66103.0 |
| Theoretical pI
| 9.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 68-91
- 105-125
- 143-164
- 185-207
- 230-252
- 493-513
- 528-547
|
| Protein Sequence
|
>Muscarinic acetylcholine receptor M3
MTLHNNNTTSPLFPNISSSWIHGPSDTGLPPGTVTHFGSYNISRAAGNLSSPNGTTSDPL
GGHTIWQVVFIAFLTGVLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFILWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQSM
KRSARRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGSVGLERKPSKLQTQQSMDDGGSF
QKSFSKLPIQLESAVDTAKASDVNSSVGKTTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVN
PVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
|
| External Links |
|---|
| GenBank ID Protein
| AAA51866.1 |
| UniProtKB/Swiss-Prot ID
| P41984 |
| UniProtKB/Swiss-Prot Entry Name
| ACM3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U08286 |
| GeneCard ID
| CHRM3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
