| Identification |
|---|
| BMDB Protein ID
| BMDBP01824 |
| Secondary Accession Numbers
| None |
| Name
| Follicle-stimulating hormone receptor |
| Synonyms
|
Not Available
|
| Gene Name
| FSHR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in follicle-stimulating hormone receptor activity |
| Specific Function
| G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. |
| Pathways
|
- Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
- Vasopressin Regulation of Water Homeostasis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| FSHR |
| Gene Sequence
|
>2088 bp
ATGGCCTTGCTCCTGGTGGCCTTGCTCGCATTCCTGAGCCTGGGCTCAGGATGCCATCAT
CGACTCTGTCACTGCTCTAACGGAGTTTTCCTCTGCCAGGAGAGCAAGGTGACAGAGATT
CCCTCCGACCTCCCCAGGGATGCAGTCGAACTGAGGTTTGTTCTCACCAAGCTTCGAGTC
ATCCCAAAAGGAGCCTTTTCAGGATTTGGAGACCTGGAGAAAATAGAGATCTCACAGAAT
GATGTCTTGGAAGTGATAGAGGCAAACGTGTTCTCCAACCTGCCCAAACTACATGAAATT
AGAATTGAAAAGGCCAACAACCTGCTATACATCGACCCTGATGCCTTCCAGAACCTTCCC
AACCTCCGATATCTGTTAATATCCAACACAGGTATTAAGCACTTGCCAGCTGTTCACAAG
ATTCAGTCTCTCCAAAAGGTTTTACTAGATATTCAAGATAATATAAACATCCACACAGTT
GAAAGAAATTCTTTCATGGGGCTAAGTTTTGAAAGTATGACTGTATGGCTGAGTAAGAAT
GGGATTCAAGAAATACACAACTGTGCATTCAATGGAACCCAACTCGATGAGCTGAATCTA
AGTGATAACAGTAATTTGGAAGAACTGCCTAATGATGTTTTCCAGGGAGCCTCTGGACCG
GTCATTCTAGATATTTCAAGAACCAGGATCCGTTCCCTGCCTAGCTATGGCTTAGAAAAT
CTTAAGAAGCTGCGGGCCAAGTCAACTTACCGCTTAAAAAAGCTTCCCAGTCTGGAAAAA
TTTGTCACACTCGTGGAGGCCAGCCTCACCTACCCCAGCCACTGCTGTGCCTTTGCAAAC
TGGAGGCGGCAAACCTCTGACCTTCATCCAATTTGCAACAAATCTATTTTAAGGCAAGAA
GTTGATGACATGACTCAGGCTAGGGGTCAGAGAGTCTCTTTGGCAGAAGATGATGAGCCC
AGCTATGCCAAAGGATTTGACGTGATGTACAGTGAATTTGACTATGACTTATGCAATGAA
GTGGTTGATGTGACTTGCTCCCCTGAGCCAGACGCATTTAATCCATGTGAAGATATCATG
GGGGATGATATTCTCAGAGTCTTGATATGGTTTATTAGCATCCTGGCCATCACTGGGAAC
ATCCTAGTGCTGGTGATCCTGATCACCAGCCAGTATAAACTCACAGTCCCCCGGTTCCTC
ATGTGCAATCTGGCCTTTGCCGATCTCTGCATTGGAATCTACCTGCTGCTCATAGCCTCA
GTTGATGTCCACACCAAAACGGAGTACCACAACTATGCCATCGACTGGCAAACTGGAGCA
GGCTGTGATGCTGCCGGCTTTTTCACTGTCTTTGCCAGTGAGCTCTCAGTCTACACTCTG
ACCGCCATCACGCTGGAAAGATGGCATACCATCACCCATGCCATGCAGCTCGAATGCAAA
GTGCAGCTCCGCCATGCTGCCAGCATCATGCTGGTGGGCTGGATCTTTGCTTTTGCAGTT
GCCCTTTTTCCCATCTTTGGCATCAGCAGCTACATGAAGGTGAGCATCTGCCTGCCCATG
GACATTGACAGCCCCTTGTCACAACTCTATGTCATGTCCCTCCTTGTGCTCAATGTCCTG
GCCTTTGTGGTCATCTGTGGCTGCTACACTCACATCTACCTCACGGTGAGGAACCCCAAC
ATCACATCCTCTTCTAGTGACACCAAGATAGCCAAGCGCATGGCCATGCTCATCTTCACC
GACTTCCTCTGCATGGCACCCATCTCCTTCTTTGCCATCTCTGCCTCCCTCAAGGTGCCC
CTCATCACTGTGTCCAAGTCAAAGATCCTCCTGGTCCTGTTCTACCCCATCAACTCCTGT
GCCAACCCCTTCCTCTATGCCATCTTCACCAAGAACTTCCGCAGGGATTTCTTCATTCTG
CTGAGCAAGTTTGGCTGCTATGAAGTGCAAGCCCAGACCTATAGGTCAGAAACCTCATCC
ACTGCCCACAACTTTCATCCAAGGAACGGCCACTGCCCCCCAGCTCCCAGGGTTACTAAT
GGTTCCAATTACACACTTATCCCCCTAAGACATTTAGCCAAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 695 |
| Molecular Weight
| 78085.0 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 367-387
- 399-421
- 444-465
- 486-508
- 529-550
- 574-597
- 609-630
|
| Protein Sequence
|
>Follicle-stimulating hormone receptor
MALLLVALLAFLSLGSGCHHRLCHCSNGVFLCQESKVTEIPSDLPRDAVELRFVLTKLRV
IPKGAFSGFGDLEKIEISQNDVLEVIEANVFSNLPKLHEIRIEKANNLLYIDPDAFQNLP
NLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHTVERNSFMGLSFESMTVWLSKN
GIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVFQGASGPVILDISRTRIRSLPSYGLEN
LKKLRAKSTYRLKKLPSLEKFVTLVEASLTYPSHCCAFANWRRQTSDLHPICNKSILRQE
VDDMTQARGQRVSLAEDDEPSYAKGFDVMYSEFDYDLCNEVVDVTCSPEPDAFNPCEDIM
GDDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
VDVHTKTEYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECK
VQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
AFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVP
LITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEVQAQTYRSETSS
TAHNFHPRNGHCPPAPRVTNGSNYTLIPLRHLAKN
|
| External Links |
|---|
| GenBank ID Protein
| AAC37324.1 |
| UniProtKB/Swiss-Prot ID
| P35376 |
| UniProtKB/Swiss-Prot Entry Name
| FSHR_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| L22319 |
| GeneCard ID
| FSHR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
