| Identification |
|---|
| BMDB Protein ID
| BMDBP01831 |
| Secondary Accession Numbers
| None |
| Name
| Transcription factor MafF |
| Synonyms
|
Not Available
|
| Gene Name
| MAFF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding |
| Specific Function
| Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| MAFF |
| Gene Sequence
|
>519 bp
ATGTCTGTGGATCCCTTATCCAGCAAAGCGCTGAAGATCAAGCGTGAGCTGAGCGAAAAC
ACGCCGCACCTGTCGGACGAAGCGCTGATGGGGCTGTCTGTGCGCGAGCTGAACCGGCAC
CTGCGAGGGCTCTCGGCCGAGGAGGTGACGCGGCTCAAGCAGCGGCGCCGCACACTCAAG
AACCGCGGCTACGCGGCCAGCTGCCGCGTGAAGCGCGTGTGCCAGAAGGAGGAGCTGCAG
AAGCAGAAGTCGGAGCTGGAGCGCGAGGTGGACAAGCTGGCGCGCGAGAACGCCGCCATG
CGCTTGGAGCTCGACGCGCTGCGCGGCAAGTGCGAGGCGCTGCAGGGCTTCGCGCGCTCG
GTGGCCGCCGCCCGCGGGCCCGCGGCGCTGGTGGCGCCGGCCAGCGTCATCACTATCGTC
AAGTCGGCCCCGAGCCCCGGCCCGGGCCCCGCCCCTGGCCCGGGCCCCGCCTCCGGCCCG
GGCCCCGCCCCCGGCCCCGCCCCCGCCGCCTGCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 18231.0 |
| Theoretical pI
| 10.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transcription factor MafF
MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLK
NRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARS
VAAARGPAALVAPASVITIVKSAPSPGPGPAPGPGPASGPGPAPGPAPAACS
|
| External Links |
|---|
| GenBank ID Protein
| AAI51585.1 |
| UniProtKB/Swiss-Prot ID
| A7YY73 |
| UniProtKB/Swiss-Prot Entry Name
| MAFF_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151584 |
| GeneCard ID
| MAFF |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
