| Identification |
|---|
| BMDB Protein ID
| BMDBP01846 |
| Secondary Accession Numbers
| None |
| Name
| Calcium-activated chloride channel regulator 1 |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium channel activity |
| Specific Function
| May be involved in mediating calcium-activated chloride conductance (PubMed:8537359). May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
>2712 bp
ATGGTGCCTCGTCTGACTGTCATTCTGTTCCTAACTTTGCACCTCCTGCCTGGAATGAAA
AGTTCAATGGTAAATTTGATTAACAATGGATATGATGGCATTGTCATTGCAATTAACCCT
AGTGTGCCAGAAGATGAAAAACTCATTCAAAACATAAAGGAAATGGTAACTGAAGCTTCT
ACTTACCTGTTTCATGCCACCAAACGAAGAGTTTATTTCAGGAATGTAAGCATTTTAATT
CCAATGACGTGGAAGTCAAAATCTGAGTACTTAATGCCAAAACAAGAATCATATGACCAG
GCAGAAGTCATAGTTGCTAATCCTTACCTAAAACATGGAGATGATCCCTATACACTTCAA
TATGGAAGATGTGGAGAAAAAGGACAATATATACATTTTACTCCAAACTTCTTGCTGACT
AATAATTTGCCTATCTATGGGTCCCGAGGCAGAGCATTTGTCCATGAGTGGGCCCATCTC
CGATGGGGAATATTTGATGAGTATAACGGGGACCAGCCATTCTATATCTCCAGAAGGAAC
ACTATTGAAGCAACAAGATGTTCAACTCATATTACTGGTACTAATGTGATTGTCAAATGC
CAGGGAGGCAGCTGTATAACAAGGCCATGCAGACGTGACTCACAGACAGGGCTGTATGAG
GCAAAATGTACATTCATCCCAGAAAAATCCCAGACTGCAAGGGAGTCCATCATGTTTATG
CAAAGTCTCCATTCTGTGACTGAATTTTGTACAGAAAAAACACACAATGTGGAAGCTCCA
AACCTACAAAACAAAATGTGCAATGGCAAAAGCACATGGGATGTAATCATGAACTCTACT
GACTTTCAAAATACATCTCCCATGACAGAAATGAATCCACCGACTCAACCTACATTTTCA
TTGCTCAAGTCCAAACAGCGAGTAGTTTGTTTGGTACTTGATAAATCTGGAAGCATGTCT
TCAGAAGATCGTCTCTTTCGAATGAATCAAGCAGCAGAATTATTCTTGATTCAAATTATT
GAAAAGGGATCCTTGGTTGGGATGGTTACATTTGACAGTGTTGCTGAAATCCGAAATAAT
CTAACAAAAATAACTGATGATAATGTTTATGAAAATATCACTGCAAATCTGCCTCAAGAA
GCTAATGGTGGAACTTCAATTTGTAGGGGGCTCAAAGCAGGATTTCAGGCAATTATTCAG
AGTCAACAGAGCACTTCTGGTTCTGAAATCATACTACTAACCGATGGGGAAGATAATGAA
ATACACTCATGCATTGAGGAGGTAAAACAAAGTGGTGTGATCATTCACACCATTGCCCTG
GGACCTTCTGCTGCCAAAGAACTGGAGACACTGTCAGATATGACAGGAGGACATCGGTTT
TATGCCAATAAAGACATAAATGGCCTTACTAATGCGTTCAGTAGAATTTCATCTAGAAGT
GGCAGTATCACTCAGCAGACTATTCAGTTGGAAAGCAAAGCCTTGGCAATTACAGAAAAG
AAATGGGTAAATGGTACGGTGCCTGTGGATAGTACAATTGGAAATGACACTTTCTTTGTT
GTCACATGGACAATAAAAAAGCCAGAAATTCTTCTCCAGGATCCAAAAGGAAAGAAATAT
AAAACCTCAGATTTCAAAGAAGATAAGCTAAATATTCATTCTGCTCGTCTTCGAATACCT
GGTATTGCAGAGACAGGTACTTGGACTTACAGCCTTCTAAATAATCATGCCAGTCCTCAA
ATACTAACAGTGACAGTGACCACTCGAGCAAGAAGTCCTACTACACCCCCAGTAACTGCA
ACAGCTCACATGAGTCAAAATACAGCACACTACCCTAGCCCAGTGATTGTTTATGCACAA
GTCAGTCAAGGGTTTTTGCCTGTACTGGGAATCAATGTAACTGCCATTATAGAAACTGAA
GATGGCCATCAAGTAACACTGGAGCTCTGGGACAATGGTGCAGGTGCTGATACTGTCAAG
AATGATGGCATCTATTCAAGATATTTTACAGATTACCGTGGAAATGGTAGATACAGTTTA
AAAGTACATGCCGAGGCAAGAAACAACACGGCTAGGCTAAGTTTAAGACAACCACAGAAC
AAAGCCCTGTATATACCAGGCTATATTGAAAATGGTAAAATTATACTGAACCCACCCAGA
CCTGAAGTCAAAGATGACCTGGCAAAAGCTGAAATAGAAGACTTTAGCAGACTAACCTCT
GGAGGGTCATTTACTGTATCAGGAGCTCCTCCTGGTAATCACCCTTCTGTGCTCCCACCC
AATAAAATTATAGACCTTGAAGCAAAATTTAAAGAAGATCACATTCAACTTTCATGGACA
GCCCCTGCGAATGTCCTAGATAAAGGAAAAGCCAACAGCTACATTATAAGAATAAGTAAG
AGTTTCCTGGATCTCCAAAAAGATTTTGACAATGCTACTTTAGTGAATACTTCCAGTCTA
AAACCTAAGGAGGCCGGCTCAGATGAAAATTTTGAATTTAAACCAGAACCTTTTAGAATA
GAAAATGGCACCAACTTCTATATTGCAGTCCAAGCCATCAATGAAGCCAATCTCACCTCA
GAGGTTTCTAACATCGCACAAGCAATCAAGTTTATTCCTATGCCAGAAGACAGTGTCCCT
GCTCTGGGTACCAAGATTTCTGCAATCAATTTGGCAATTTTTGCATTAGCTATGATTTTA
TCTATAGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 903 |
| Molecular Weight
| 100306.0 |
| Theoretical pI
| 7.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Epithelial chloride channel protein
MVPRLTVILFLTLHLLPGMKSSMVNLINNGYDGIVIAINPSVPEDEKLIQNIKEMVTEAS
TYLFHATKRRVYFRNVSILIPMTWKSKSEYLMPKQESYDQAEVIVANPYLKHGDDPYTLQ
YGRCGEKGQYIHFTPNFLLTNNLPIYGSRGRAFVHEWAHLRWGIFDEYNGDQPFYISRRN
TIEATRCSTHITGTNVIVKCQGGSCITRPCRRDSQTGLYEAKCTFIPEKSQTARESIMFM
QSLHSVTEFCTEKTHNVEAPNLQNKMCNGKSTWDVIMNSTDFQNTSPMTEMNPPTQPTFS
LLKSKQRVVCLVLDKSGSMSSEDRLFRMNQAAELFLIQIIEKGSLVGMVTFDSVAEIRNN
LTKITDDNVYENITANLPQEANGGTSICRGLKAGFQAIIQSQQSTSGSEIILLTDGEDNE
IHSCIEEVKQSGVIIHTIALGPSAAKELETLSDMTGGHRFYANKDINGLTNAFSRISSRS
GSITQQTIQLESKALAITEKKWVNGTVPVDSTIGNDTFFVVTWTIKKPEILLQDPKGKKY
KTSDFKEDKLNIHSARLRIPGIAETGTWTYSLLNNHASPQILTVTVTTRARSPTTPPVTA
TAHMSQNTAHYPSPVIVYAQVSQGFLPVLGINVTAIIETEDGHQVTLELWDNGAGADTVK
NDGIYSRYFTDYRGNGRYSLKVHAEARNNTARLSLRQPQNKALYIPGYIENGKIILNPPR
PEVKDDLAKAEIEDFSRLTSGGSFTVSGAPPGNHPSVLPPNKIIDLEAKFKEDHIQLSWT
APANVLDKGKANSYIIRISKSFLDLQKDFDNATLVNTSSLKPKEAGSDENFEFKPEPFRI
ENGTNFYIAVQAINEANLTSEVSNIAQAIKFIPMPEDSVPALGTKISAINLAIFALAMIL
SIV
|
| External Links |
|---|
| GenBank ID Protein
| AAC48511.1 |
| UniProtKB/Swiss-Prot ID
| P54281 |
| UniProtKB/Swiss-Prot Entry Name
| CLCA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U36445 |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
