| Identification |
|---|
| BMDB Protein ID
| BMDBP01852 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit alpha-5 |
| Synonyms
|
Not Available
|
| Gene Name
| GABRA5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| GABRA5 |
| Gene Sequence
|
>1389 bp
ATGGACAATGGAATGTTCTCTAGCTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT
TCCATGAACTTAGCCAGTCACTTTGGCTTTTCACAAATGCCAACCAGCTCTGTAAAAGCT
GAGACCGATGACAACATCACGATATTCACCAGGATCCTGGATGGGCTGCTGGACGGTTAC
GACAACAGACTGAGGCCCGGGCTCGGAGAGCGTATCACTCAGGTGAGAACGGACATCTAC
GTCACCAGCTTCGGCCCCGTGTCCGACACGGAGATGGAATATACCATCGACGTATTTTTC
CGACAAAGCTGGAAAGACGAAAGGCTTCGGTTTAAAGGGCCCATGCAGCGCCTTCCACTC
AACAATCTCCTCGCCAGCAAAATTTGGACTCCAGACACGTTCTTCCACAACGGGAAGAAG
TCCATCGCCCACAACATGACCACGCCCAACAAGCTGCTGCGTCTGGAGGACGACGGCACG
CTGCTGTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCAATGCAACTTGAAGACTTT
CCAATGGATGCCCATGCCTGCCCTCTGAAATTTGGCAGCTACGCATATCCTAATTCCGAA
GTCATCTATGTCTGGACCAACGGCACCGCCAAGTCAGTGGTGGTGGCAGAAGATGGCTCC
AGGCTGAACCAGTACCACCTCATGGGGCAGACCGTGGGCACGGAGAACATCAGCACCAGC
ACAGGTGAATACACAATCATGACAGCTCATTTCCATCTGAAGAGGAAGATTGGCTACTTT
GTCATCCAGACCTACCTCCCCTGCATCATGACCGTGATCTTGTCACAAGTGTCCTTTTGG
CTGAACCGAGAATCAGTTCCTGCCAGGACAGTGTTTGGGGTGACCACGGTGCTGACCATG
ACCACCCTCAGCATCAGCGCCCGGAACTCTCTGCCCAAAGTGGCTTATGCAACAGCCATG
GACTGGTTCATAGCCGTGTGTTACGCTTTTGTGTTCTCTGCGCTGATCGAGTTTGCTACC
GTCAACTATTTCACAAAGAGAGGCTGGGCCTGGGATGGGAAAAAAGCCTTGGAAGCAGCC
AAGATCAAGAAAAAGGAGCGTGAGCTTACAATAAATAAGTCAACAAACGCTTATACTACT
GGGAAGATGACCCACCCCCCGAACATCCCAAAGGAGCAGACCCCTGCAGGGACCACAAAT
GCCTCTTCAGCCTCAGTAAAACCTGAAGACAAGGCTTCTGAAAACAAAAAGACTTACAAC
AGCATCAGCAAGATTGACAAAATGTCCCGAATTATATTCCCACTTCTGTTTGGCACTTTC
AACCTAGTCTACTGGGCAACGTATTTGAATAGGGAGCCAGTGATTAAAGGGGCTACCTCT
CCAAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 462 |
| Molecular Weight
| 52172.0 |
| Theoretical pI
| 9.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 260-281
- 286-307
- 319-341
- 428-449
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit alpha-5
MDNGMFSSFIMIKNLLLFCISMNLASHFGFSQMPTSSVKAETDDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVIYVWTNGTAKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKERELTINKSTNAYTTGKMTHPPNIPKEQTPAGTTNASSASVKPEDKASENKKTYN
SISKIDKMSRIIFPLLFGTFNLVYWATYLNREPVIKGATSPK
|
| External Links |
|---|
| GenBank ID Protein
| AAI23419.1 |
| UniProtKB/Swiss-Prot ID
| Q08E50 |
| UniProtKB/Swiss-Prot Entry Name
| GBRA5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123418 |
| GeneCard ID
| GABRA5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
