| Identification |
|---|
| BMDB Protein ID
| BMDBP01857 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit alpha-4 |
| Synonyms
|
Not Available
|
| Gene Name
| GABRA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| GABRA4 |
| Gene Sequence
|
>1671 bp
ATGGTTTCTGCCAAGAAGGTACCCGCGATCGCGATGTCCTTCGGGGTCAGTTTCGCCCTC
CTGCACTTCCTGTGCCTGGCGGCTTGTTTAAACGAATCCCCAGGACAGAACCAAAAGGAG
GAGAAATTATGCCCAGAAAATTTTACCCGCATCCTGGACAGTTTACTCGATGGTTATGAC
AACAGGCTGCGTCCTGGATTTGGGGGTCCTGTTACAGAAGTGAAAACTGACATATATGTC
ACTAGCTTTGGACCTGTTTCCGATGTTGAAATGGAATACACAATGGATGTGTTCTTCAGA
CAGACATGGATTGACAAAAGACTAAAATATGATGGCCCCATTGAAATTTTGAGATTGAAC
AATATGATGGTAACAAAAGTGTGGACTCCTGATACTTTCTTCAGGAATGGAAAGAAATCT
GTCTCACATAATATGACAGCTCCAAATAAACTTTTTAGAATTATGAGAAATGGCACAATT
TTATACACAATGAGACTCACCATAAGTGCAGAATGTCCCATGAGATTGGTGGACTTCCCC
ATGGATGGCCATGCCTGCCCTTTGAAATTTGGGAGTTATGCCTATCCGAAGAGTGAGATG
ATTTATACCTGGACAAAAGGTCCTGAGAAATCAGTAGAAGTTCCAAAGGAGTCTTCCAGC
TTAGTTCAGTATGACTTGATTGGGCAAACTGTATCGAGTGAAACTATCAAATCCATCACA
GGTGAATATATTGTTATGACGGTTTATTTTCACCTCAGACGGAAGATGGGTTATTTTATG
ATTCAAACATACATTCCATGTATTATGACAGTAATTCTTTCTCAAGTTTCATTCTGGATA
AATAAGGAATCAGTTCCAGCTAGGACTGTATTTGGAATAACCACAGTCCTGACCATGACC
ACACTGAGCATCAGTGCACGGCCAATTTCTTTACCCAAAGTGTCCTATGCAACTGCCATG
GATTGGTTCATAGCTGTCTGCTTTGCTTTTGTATTTTCGGCCCTTATTGAGTTTGCTGCC
GTCAACTACTTTACCAATGTTCAAATGGAAAAAGCCAAAAGGAAGACATCAAAAGCCCCC
CAGGAAATTTCAGCTGCTCCAGTGCTGAGAGAAAAGCATCCTGAAACACCTCTGCAGAAC
ACAAATGCCAATTTGAGCATGAGAAAAAGAGCCAACGCCTTGGTTCACTCTGAATCTGAT
GTTGGCAGCAGAACTGATGTGGGAAACCATTCTAGCAAGTCTTCCACGGTTGTTCAAGGA
TCTTCTGAAGCCACACCACAGTCTTACTTAGCTTCCAGTCCAAACCCATTTAGCCGTGCA
AATGCAGCTGAAACTATATCTGCCGCAAGAGCAATTCCATCTGCTCTTCCTTCTACTCCT
AGTAGAACTGGGTATGTGCCCCGACAAGTCCCAGTTGGATCTGCTTCTACCCAGCATGTG
TTTGGATCAAGACTGCAGCGAATTAAGACCACAGTTAATAGCATAGGGACTTCGGGGAAG
TTATCAGCCACTACTACTCCCTCTGCTCCACCACCTTCTGGATCTGGCACAAGTAAAATA
GACAAATATGCCCGCATTCTCTTTCCAGTAACATTTGGGGCATTTAATATGGTCTATTGG
GTTGTTTACTTATCTAAGGACACTATGGAGAAATCAGAAAGTCTAATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 555 |
| Molecular Weight
| 61547.0 |
| Theoretical pI
| 9.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 259-280
- 285-306
- 318-340
- 525-544
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit alpha-4
MVSAKKVPAIAMSFGVSFALLHFLCLAACLNESPGQNQKEEKLCPENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNVQMEKAKRKTSKAPQ
EISAAPVLREKHPETPLQNTNANLSMRKRANALVHSESDVGSRTDVGNHSSKSSTVVQGS
SEATPQSYLASSPNPFSRANAAETISAARAIPSALPSTPSRTGYVPRQVPVGSASTQHVF
GSRLQRIKTTVNSIGTSGKLSATTTPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWV
VYLSKDTMEKSESLM
|
| External Links |
|---|
| GenBank ID Protein
| CAA43696.1 |
| UniProtKB/Swiss-Prot ID
| P20237 |
| UniProtKB/Swiss-Prot Entry Name
| GBRA4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X61456 |
| GeneCard ID
| GABRA4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
