1.0 2018-05-07 22:28:56 UTC 2020-05-20 21:04:40 UTC BMDBP01865 Enzyme GABRA2 Involved in chloride channel activity Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2842688). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). BMDB0000112 Gamma-Aminobutyric acid BMDB0000492 Chlorine 6 >1356 bp ATGAAGACGAAACTGAACAGCTCCAATATGCAGTTGCTGCTTTTTGTTTTCTTGGCGTGG GATCCAGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACAAGAATTCTAGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTATGTGACCAGTTTTGGCCCTGTC TCAGATACAGACATGGAATATACAATCGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGATTAAAATTTAAAGGTCCTATGAACATCCTTCGACTCAACAATTTAATGGCCAGCAAA ATCTGGACTCCAGATACCTTTTTCCACAATGGGAAGAAATCGGTGGCACACAATATGACA ATGCCAAATAAGCTTCTCCGAATCCAGGATGATGGGACCCTGCTGTACACAATGAGGCTT ACAGTTCAAGCTGAATGTCCAATGCACTTGGAGGATTTTCCAATGGATGCCCACTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACCTCAGAGGTTACTTACATTTGGACATAC AATGCGTCTGATTCTGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGATCTG CCGGGCCAATCAATTGGGAAGGAGACAATTAAATCTAGTACAGGTGAATATACCGTAATG ACAGCTCATTTCCACTTGAAAAGAAAAATTGGATATTTTGTGATTCAGACATATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTGTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACAGTGTTTGGAGTAACAACTGTTCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGC TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGAAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAAGCCTCTGTG ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GACCCAGTTCTCTCCACCATCTCCAAGAGCGCAACCACTCCAGAACCCAACAAGAAACCG GAAAACAAGCCAGCCGAAGCCAAGAAGACCTTCAATAGCGTTAGCAAAATTGACAGAATG TCTAGAATAGTTTTCCCAGTTTTGTTTGGTACATTTAATTTAGTTTACTGGGCCACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA 451 51146.0 9.51 252-273 279-300 313-334 420-441 1-28 >Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNSSNMQLLLFVFLAWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLPGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP CAA30924.1 P10063 GBRA2_BOVIN X12361 GABRA2