| Identification |
|---|
| BMDB Protein ID
| BMDBP01870 |
| Secondary Accession Numbers
| None |
| Name
| Anoctamin-4 |
| Synonyms
|
Not Available
|
| Gene Name
| ANO4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| ANO4 |
| Gene Sequence
|
>2763 bp
ATGGAGACGAGCTCTTCTGGAATCACTAATGGGAGAACCAGAGTCTTCCACCCAGTGGCC
AAGGATGTCAATATTCTTTTTGATGAATTAGAAGCTGTCAACAGTCCTTGCAAAGATGAC
GACTCTCTCCTTCACCCTGGAAATCTTACCAGTACTTCAGATGATGCTAGCAGGTTGGAA
GCCGGGGGAGAGACAGTACCAGAAAAAAACAAATTAAATGGCCTTTACTTCAGAGACGGA
AAATGTCGAATTGACTACATTCTTGTGTACAGAAAATCCAACCCCCAGATGGAAAAGAGA
GAAGTATTTGAAAGAAATATTAGAGCAGAAGGATTACAAATGGAGAAAGAGTCCTCTCTA
ATAAATAGTGACATTATCTTTGTGAAGTTGCATGCCCCATGGGAAGTGCTTGGAAGATAT
GCAGAACAAATGAATGTAAGAATGCCTTTCAGGAGAAAAATCTATTACCTGCCCCGCCGG
TACAAGTTCATGAGCAGGATCGATAAACAAATAAGCAGGTTTCGGAGATGGTTACCTAAG
AAGCCAATGAGGCTGGACAAGGAGACACTGCCAGACCTGGAGGAGAATGACTGCTACACT
GCCCCTTTCAGCCAGCAAAGGATCCATCACTTCATCATACACAACAAAGACACTTTCTTC
AACAATGCCACAAGAAGTAGAATTGTACATCATATTTTACAAAGAATAAAGTATGAAGAA
GGAAAAAACAAAATTGGTCTGAATCGTTTGCTTACTAATGGCTCCTATGAAGCTGCATTT
CCTCTGCACGAGGGAAGTTACAGAAGTAAAAACTCCATCAGAACCCACGGAGCGGTAAAC
CACCGACATCTGCTCTATGAGTGCTGGGCGTCCTGGGGTGTGTGGTACAAATACCAGCCT
TTGGATCTTGTAAGGCGGTACTTTGGAGAGAAGATTGGGTTGTACTTTGCCTGGTTGGGC
TGGTACACCGGCATGCTCTTCCCAGCTGCCTTCATTGGATTGTTTGTCTTTTTGTATGGC
GTCATCACTCTGGATCACTGCCAAGTCAGTAAAGAAGTCTGCCAAGCTACAGATATCATC
ATGTGTCCTGTGTGTGATAAATACTGTCCATTCATGAGGCTGTCAGACAGCTGCGTTTAT
GCCAAGGTAACCCATCTTTTTGACAATGGAGCCACTGTTTTCTTTGCTGTTTTCATGGCA
GTCTGGGCAACAGTTTTCCTAGAGTTTTGGAAGAGACGGAGAGCAGTAATTGCTTATGAC
TGGGATTTGATAGACTGGGAAGAAGAGGAGGAAGAAATACGGCCCCAGTTTGAAGCCAAG
TATTCCAAGAAAGAGAGGATGAATCCCATTTCCGGCAAGCCAGAACCATATCAAGCATTT
GCAGATAAATGCAGCCGACTTATTGTTTCTGCATCTGGAATATTTTTTATGATCTGCGTG
GTGATCGCCGCTGTGTTCGGGATTGTCATTTACAGGGTGGTGACCGTCAGCACTTTCGCA
GCCTTTAAGTGGGCATTAATCAGGAATAATTCTCAGGTTGCAACTACAGGAACTGCTGTG
TGCATCAATTTCTGCATCATTATGCTGCTGAATGTGCTCTATGAAAAGGTTGCTCTTCTT
CTGACAAATTTAGAACAGCCTCGCACAGAGTCCGAGTGGGAGAACAGCTTCACCCTGAAA
ATGTTTCTTTTTCAGTTTGTCAATCTGAACAGCTCCACATTTTACATCGCGTTCTTCCTC
GGAAGATTCACAGGACACCCAGGTGCCTACTTGAGGCTGATAAACAGGTGGAGACTAGAA
GAGTGCCACCCTAGTGGATGCCTTATTGATCTCTGTATGCAAATGGGTATTATAATGGTG
CTAAAGCAGACCTGGAATAATTTCATGGAACTTGGCTACCCGTTAATTCAGAATTGGTGG
ACTAGAAGAAAAGTACGACAAGAACATGGGCCTGAAAGGAAAATAAGTTTCCCACAATGG
GAAAAGGACTACAACCTTCAGCCGATGAATGCCTACGGACTCTTTGATGAATACTTAGAA
ATGATTCTTCAGTTTGGATTTACAACTATCTTTGTGGCAGCTTTTCCCCTAGCACCACTT
CTGGCCTTACTGAATAATATAATTGAAATTCGACTTGACGCTTATAAATTTGTCACACAG
TGGAGGCGACCTTTAGCTTCAAGGGCCAAAGATATAGGAATTTGGTATGGGATTCTTGAA
GGCATTGGAATTCTCTCCGTTATTACAAATGCATTTGTGATAGCGATCACATCTGACTTT
ATCCCTCGCTTGGTATATGCTTATAAGTATGGACCTTGTGCGGGCCAAGGAGAAGCTGGG
CAAAAGTGCATGGTTGGCTATGTGAATGCCAGCTTGTCTGTATTCCGAATTTCTGACTTT
GAGAACAGATCTGAACCTGAGTCTGATGGCAGTGAGTTCTCGGGGACTCCTCTCAAGTAC
TGTAGATACCGAGACTACCGTGACCCTCCTCATTCACTGGTGCCCTACGGCTACACACTA
CAGTTCTGGCACGTCCTAGCAGCCCGACTGGCTTTTATCATTGTGTTCGAGCACCTCGTG
TTTTGTATAAAGCACCTCATTTCATATCTGATCCCAGACCTCCCAAAAGATCTAAGGGAT
CGAATGAGAAGAGAGAAGTACTTGATTCAGGAGATGATGTATGAAGCAGAACTGGAGCGT
CTCCAGAAGGAACGAAAGGAGAGGAAGAAAAATGGAAAAGCACACCACAATGAGTGGCCG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 920 |
| Molecular Weight
| 107708.0 |
| Theoretical pI
| 8.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 324-344
- 390-410
- 471-491
- 513-533
- 561-581
- 681-701
- 734-754
- 851-871
|
| Protein Sequence
|
>Anoctamin-4
METSSSGITNGRTRVFHPVAKDVNILFDELEAVNSPCKDDDSLLHPGNLTSTSDDASRLE
AGGETVPEKNKLNGLYFRDGKCRIDYILVYRKSNPQMEKREVFERNIRAEGLQMEKESSL
INSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPK
KPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYEE
GKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQP
LDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVCQATDII
MCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYD
WDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFADKCSRLIVSASGIFFMICV
VIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALL
LTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLE
ECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQW
EKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQ
WRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAG
QKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTL
QFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELER
LQKERKERKKNGKAHHNEWP
|
| External Links |
|---|
| GenBank ID Protein
| AAI47938.1 |
| UniProtKB/Swiss-Prot ID
| A6QLE6 |
| UniProtKB/Swiss-Prot Entry Name
| ANO4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC147937 |
| GeneCard ID
| ANO4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
