| Identification |
|---|
| BMDB Protein ID
| BMDBP01874 |
| Secondary Accession Numbers
| None |
| Name
| Sodium/myo-inositol cotransporter 2 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC5A11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sodium ion binding |
| Specific Function
| Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
| Pathways
|
- Lactose Degradation
- Trehalose Degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| SLC5A11 |
| Gene Sequence
|
>2025 bp
ATGGAGAGCAGCGCCAGCAGCCCTCCTCTCACACAGTCAGATCCCCTGGAGGCGTTTCCC
CGGAGGACGCTGGAAGCAGGAGACATCGCAGTGCTGGTTCTATATTTCCTCTTTGTCCTG
GCTGTTGGACTATGGTCCACAGTGAAGACCAAAAGAGACACCGTGAAAGGCTACTTTCTA
GCTGGAGGCAACATGCTGTGGTGGCCAGTGGGTGCATCCTTGTTTGCCAGCAACGTTGGA
AGTGGACATTTCGTTGGCCTGGCAGGGTCAGGTGCTGCTGCGGGTCTTTCTGTAACTGCT
TATGAGCTTAATGGCTTATTTTTCGTGCTGATGTTGTCCTGGATCTTCCTTCCAATCTAC
ATCACTGGTCAGGTCACCACGATGCCAGAGTACCTACGGAAACGTTTTGGTGGCAACAGG
ATTCCCATCATCCTGGCTGTGCTCTACCTGTTTATCTACATCTTCACCAAGATCTCGGTG
GACATGTATGCAGGCGCCATCTTCATTCAGCAGTCTTTGCATGTGAATCTCTACTTGGCC
ATAGTCGGGTTGCTGGCCGTCACAGCTCTATACACCATCGCAGGTGGCCTGGCAGCTGTG
ATCTACACGGATGCTCTACAGACTCTGATCATGCTTATAGGAGCGCTCATCCTGATGGGC
TACAGTTTTGCTGCAGTTGGTGGGTTGGAAGGCTTGGAGGAGAAATATTTTTTGGCAATG
GCCAGCAACCGGAGCGGGAACAGCAGCTGCGGGTTGCCCCGGGAAGATGCCTTCCATATT
TTCCGAGACCCAGTGACGTCTGATCTCCCATGGCCCGGGATCCTATTTGGAATGTCCATC
CCGTCTCTCTGGTATTGGTGCACGGATCAGGTGATTGTTCAGCGGACTCTGGCTGCCAAG
AACCTGTCCCACGCCAAAGGGGGCTCTCTGATGGCCGCATACCTGAAGGTGCTACCCCTT
TTCATCATGGTGTTCCCGGGTATGGTCAGCCGTGTCCTCTTTCCAGACGAAGTAGCTTGT
GCAGACCCAGAAATCTGCCGGAAGGTCTGTAGCAACCCCGCCGGCTGCTCTGACATCGCG
TATCCCAAACTTGTGCTGGAACTCCTGCCTACAGGGCTCCGTGGGCTCATGATGGCTGTG
ATGGTGGCGGCGCTCACGTCTTCCCTCACCTCCATCTTTAACAGTGCCAGCACCATCTTC
ACCATGGACCTCTGGAACCATCTCCGGCCTCGGGCATCTGAGAAGGAGCTCATGATTGTG
GGCAGGGTGTTTGTGTTGCTTCTGGTGTTGGTCTCCATCCTCTGGATCCCTGTGGTCCAG
GCCAGCCAGGGCGGCCAGCTCTTCATCTACATCCAGTCCATCAGCTCCTACCTACAGCCA
CCTGTGGCTGTGGTCTTCATCATGGGATGTTTCTGGAAGCGGGCCAATGAAAAGGGTGCC
TTCTTCGGTCTCGTCTTAGGCCTCCTCCTAGGCTTGGTTAGGCTGATCCTGGACTTCATT
TACGTGCAGCCTCGCTGTGACCAGCTGGATGAGCGCCCAGCCGTGGTAAAGGATGTCCAC
TACCTCTACTTCTCTATGATCCTGTCCTCGGTCACCCTGATCACAGTGTGTGCCGTGAGC
TGGTTCACAGAGCCGCCCTCCAAGGAAATGGTCAGTCGCTTGACCTGGTTTACTCGCCAT
GACCCCGTGGTCCAGAAGGAACAGGTGCCGTCAGCAACCCCACCGCCTCTTACCCTTTCT
CAAAACGGGACACCAGAGGCCAGCGGCACCAACACCCAGTTCGAGATGGTTCAAGAAAAC
CTGTCCAAAACCCACAGCTGCGACATGACCACAAAGCGGTCCAAAGTGGTGAAAGCCATC
TTGTGGCTCTGTGGGGTGGAGAACAAGGGCAAGGAGCAAGCACCCAGCAGAGCGGACCCG
ATCATAGTTTCCCTGGAAGAAAACCCCTTGGTGAAAACCCTTCTGGACCTCAACCTCATC
ATTTGCATCAGCTGTGCCATATTTCTCTGGGGCTACTTTGCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 674 |
| Molecular Weight
| 73957.0 |
| Theoretical pI
| 7.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 26-46
- 57-77
- 103-123
- 141-161
- 181-201
- 209-229
- 273-293
- 309-329
- 375-397
- 419-439
- 447-467
- 480-500
- 522-542
- 654-674
|
| Protein Sequence
|
>Sodium/myo-inositol cotransporter 2
MESSASSPPLTQSDPLEAFPRRTLEAGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFL
AGGNMLWWPVGASLFASNVGSGHFVGLAGSGAAAGLSVTAYELNGLFFVLMLSWIFLPIY
ITGQVTTMPEYLRKRFGGNRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHVNLYLA
IVGLLAVTALYTIAGGLAAVIYTDALQTLIMLIGALILMGYSFAAVGGLEGLEEKYFLAM
ASNRSGNSSCGLPREDAFHIFRDPVTSDLPWPGILFGMSIPSLWYWCTDQVIVQRTLAAK
NLSHAKGGSLMAAYLKVLPLFIMVFPGMVSRVLFPDEVACADPEICRKVCSNPAGCSDIA
YPKLVLELLPTGLRGLMMAVMVAALTSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIV
GRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRANEKGA
FFGLVLGLLLGLVRLILDFIYVQPRCDQLDERPAVVKDVHYLYFSMILSSVTLITVCAVS
WFTEPPSKEMVSRLTWFTRHDPVVQKEQVPSATPPPLTLSQNGTPEASGTNTQFEMVQEN
LSKTHSCDMTTKRSKVVKAILWLCGVENKGKEQAPSRADPIIVSLEENPLVKTLLDLNLI
ICISCAIFLWGYFA
|
| External Links |
|---|
| GenBank ID Protein
| AAI02963.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZC26 |
| UniProtKB/Swiss-Prot Entry Name
| SC5AB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102962 |
| GeneCard ID
| SLC5A11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
