| Identification |
|---|
| BMDB Protein ID
| BMDBP01876 |
| Secondary Accession Numbers
| None |
| Name
| G-protein coupled receptor 84 |
| Synonyms
|
Not Available
|
| Gene Name
| GPR84 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor activity |
| Specific Function
| Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| GPR84 |
| Gene Sequence
|
>1191 bp
ATGTGGAACGCTTCTGACGTCAACTTCTCCTGCTACCATGAGTCTGTGCTGGGCTATCGT
TACGTGGCAGTTAGCTGGGGAATTGTGGTGGCCGTGACGGGCACGGTGGGCAACGTGCTC
ACCCTGCTGGCCTTGGCCATCCAGCCCAAGCTCCGAACCCGCTTCAACCTGCTCATCGCC
AACCTCACAGTGGCTGATCTGCTCTATTGCACCCTTCTCCAGCCCTTCTCGGTGGACACC
TACCTCCACCTGCACTGGCGCACCGGTGCCACCTTCTGCCAGATCTTTGGGTTCCTCCTT
TTTGTATCCAACTCTGTCTCCATCCTCACCCTCTGCCTCATCGCCCTGGGGCGCTATCTC
CTCATTGCCCACCCTAAGCTCTTTCCCCAAGTTTTCAGTGCCAAGGGCATAGTGCTGGCA
CTGGTGAGCACCTGGGTGGTGGCTGTGGCCAGCTTCGCTCCCCTCTGGCCAATCTATATC
TTGGTGCCCGTAGTCTGCACTTGCAGCTTTGATCGCATCCGAGGCCAGCCCTACACCACC
ATCCTCATGGGCATCTATTTTGTGGTTGGGCTCAGCAGTGTCGGTGTCTTCTATTGCCTC
ATCCACCAGCAGGTGAAGCGAGCAGCACAGGCAATGAATCAGTACAAGCTGCGCCAGGCA
AGCATCCGTTCCAACCATGTGGCTGGGGCACACGAGGCCGTGCCTGGTCGTTTCCAGGAG
CTAGACAGTGGGCTGGCATCAGGAGGACCCAGCGAGGGGATTTCATCTGAGCCAGTCAGT
GCTGCCACCACCCAGACCCTGGAAGGAGACTCATCAGAAGTCAGGGACCAGAGCAACAGT
AAGGCAGCTAAGCAGATGGCAGAGAAAAACCCTCCAGGAGTGGCTGCCAAGGCCAGGACA
ACTAAAGGAGCCCAGAGAGCTCAGGACTCTCCATCAGAGTTTGGGAAGGTAACCCGGATG
TGTTTTGCTGTGTTCCTCTGCTTCACCCTGAGCTACATCCCTTTCTTGCTACTCAACATC
CTGGATGCCAAGGTCCAGGCTCCCCGAGTTGTCCACATGCTCGCTGCCAACCTCACCTGG
CTTAATGGCTGCATCAACCCTGTGCTGTACGCAGCCATGAACCGCCAGTTCCGCCAAGCC
TACGGCTCCCTCCTGAGACGAGGGCCCCAGAGTTTCCATAGGTTCCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 396 |
| Molecular Weight
| 43517.0 |
| Theoretical pI
| 9.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 27-47
- 58-78
- 95-115
- 145-165
- 181-201
- 321-341
- 353-373
|
| Protein Sequence
|
>Probable G-protein coupled receptor 84
MWNASDVNFSCYHESVLGYRYVAVSWGIVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIA
NLTVADLLYCTLLQPFSVDTYLHLHWRTGATFCQIFGFLLFVSNSVSILTLCLIALGRYL
LIAHPKLFPQVFSAKGIVLALVSTWVVAVASFAPLWPIYILVPVVCTCSFDRIRGQPYTT
ILMGIYFVVGLSSVGVFYCLIHQQVKRAAQAMNQYKLRQASIRSNHVAGAHEAVPGRFQE
LDSGLASGGPSEGISSEPVSAATTQTLEGDSSEVRDQSNSKAAKQMAEKNPPGVAAKART
TKGAQRAQDSPSEFGKVTRMCFAVFLCFTLSYIPFLLLNILDAKVQAPRVVHMLAANLTW
LNGCINPVLYAAMNRQFRQAYGSLLRRGPQSFHRFH
|
| External Links |
|---|
| GenBank ID Protein
| ABQ12923.1 |
| UniProtKB/Swiss-Prot ID
| Q2KI97 |
| UniProtKB/Swiss-Prot Entry Name
| GPR84_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT030483 |
| GeneCard ID
| GPR84 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
