1.0 2018-05-07 22:29:06 UTC 2020-05-20 21:07:10 UTC BMDBP01900 Enzyme COLEC11 Involved in binding Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. BMDB0000169 D-Mannose BMDB0000174 L-Fucose BMDB0000464 Calcium 8 >804 bp ATGAAGCGGGCTCTGGCTCTGATGGGCCTGGCCTTCCTGTGTGTGCTCCGGGCTGGGGCC GCGCAGCAGACAGTGGACGACGCCTGCTCTGTGCAGATCCTCGTTCCCGGCCTCAAAGGG GATGCTGGTGAGAAGGGGGACAAAGGCGCCCCAGGACGGCCCGGGAGAGTCGGCCCCACG GGAGAGAAAGGAGACGTGGGCGACAAGGGACAGAAGGGCGGCGTGGGGCGCCACGGGAAG ATCGGCCCCATTGGCTCCAAAGGTGAAAAAGGAGATTCTGGTGACATAGGACCCCCTGGC CCTAACGGAGAACCAGGCATCCCGTGCGAGTGCAGCCAGCTGAGGAAGGCCATCGGGGAG ATGGACAACCAGGTCACCCAGCTCACGGCCGAGCTGAAGTTCATAAAGAACGCCGTTGCC GGGGTGCGCGAGACGGAGCAGAAGATGTACCTGCTGGTGAAGGAGGAGAAGCGCTACCTG GACGCGCAGCTGGCCTGCCAGGGCCGGGGCGGCACACTGAGCATGCCCAAGGACGAGGCC GCCAACGCGCTGCTGGCCGCCTACATCACGCAGGCCGGCCTGGCCCGCGTCTTCATCGGC ATCAATGACCTGGAGAGGGAAGGCGCGTTCGTCTACGCGGACCGCTCGCCGATGCAGACC TTCAGCAAGTGGCGCAGCGGGGAACCCAACAACGCCTACGACGAGGAGGACTGCGTGGAG CTGGTGGCCTCAGGGGGTTGGAACGACGTGGCCTGCCACCTTACCATGCACTTCCTCTGC GAGTTCGACAAGGAGCACGTGTAG 267 28333.0 5.45 81-106 1-21 >Collectin-11 MKRALALMGLAFLCVLRAGAAQQTVDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPT GEKGDVGDKGQKGGVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGIPCECSQLRKAIGE MDNQVTQLTAELKFIKNAVAGVRETEQKMYLLVKEEKRYLDAQLACQGRGGTLSMPKDEA ANALLAAYITQAGLARVFIGINDLEREGAFVYADRSPMQTFSKWRSGEPNNAYDEEDCVE LVASGGWNDVACHLTMHFLCEFDKEHV AAI18359.1 Q17QH6 COL11_BOVIN BC118358 COLEC11