| Identification |
|---|
| BMDB Protein ID
| BMDBP01932 |
| Secondary Accession Numbers
| |
| Name
| Coagulation factor V |
| Synonyms
|
Not Available
|
| Gene Name
| F5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| Pathways
|
Not Available
|
| Reactions
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| F5 |
| Gene Sequence
|
>6636 bp
ATGTTCCTCGCTTGCCCTGGCTTCTGGGTCCTCGTGGTCCTAGGCAGCAGCTGGGCAGGC
TGGGGGAACCTAGGGGCTGAAGCAGCAAAGCTAAGGCAGTTCTACGTAGCTGCTCAGAGC
ATCAGATGGAACTACCGCCCCGAGTCCACACACCTCAGTTCGAAACCTTTTGAAACCTCC
TTTAAGAAAATTGTCTACAGGGAGTATGAAGCATATTTTCAGAAAGAAAAACCACAATCC
AGAACTTCAGGACTTCTTGGGCCTACTTTGTATGCTGAAGTTGGAGACATCATGAAAGTT
CACTTTAAGAATAAAGCACACAAGCCCTTAAGCATCCATGCTCAAGGAATTAAGTACAGT
AAATTCTCAGAAGGTGCGTCTTACTCTGACCACACACTCCCCATGGAGAAGATGGATGAT
GCTGTAGCTCCGGGCCAAGAATATACCTATGAGTGGATTATCAGTGAGCACAGTGGGCCC
ACCCACGATGACCCTCCATGCCTCACACACATCTATTACTCCTATGTAAATCTGGTGGAG
GACTTCAACTCTGGACTGATTGGACCTCTGCTTATTTGTAAGAAAGGCACCCTAACCGAG
GATGGAACTCAGAAAATGTTTGAGAAGCAACATGTACTGATGTTTGCTGTGTTTGATGAA
AGTAAAAGCTGGAACCAGACATCATCCTTAATGTACACAGTCAATGGCTATGTGAATGGG
ACGATGCCAGATATAACAGTCTGTGCCCATGACCACATCAGTTGGCATCTGATTGGAATG
AGCTCTGGGCCAGAACTGTTCTCCATCCATTTCAATGGTCAGGTCCTGGAGCAGAACCAT
CATAAGATCTCAGCCATCACTCTCGTCAGCGCCACGTCCACAACCGCAAACATGACCGTG
AGCCCCGAGGGAAGGTGGACCATAGCTTCTCTCATCCCCAGACATTTTCAAGCTGGGATG
CAGGCTTACATAGACATTAAAAACTGTGCAAAGAAAACCAGAAATCCTAAGAAACTAACT
CGAGACCAGAGGCGGCACATTAAGAGATGGGAATACTTCATTGCTGCAGAGGAAGTCATT
TGGGACTATGCACCTATAATACCAGCAAACATGGACAAAAAATACAGATCTCTGCATTTG
GATAATTTCTCAAACCGAATTGGAAAACATTATAAGAAGGTTGTCTACAAACAGTACCAA
GATGACTCCTTCACCAAACGCCTGGAGGATCCCAGTAGTGAAGGAGATGGGATCTTGGGC
CCTATTATCAGAGCCCAGGTCAGAGACACACTGAAAATCGTGTTCAAAAATATGGCCAGC
CGCTCCTACAGCATTTACCCTCACGGTGTGACATTCTCTCCTTATGACAATGAAGTAAAC
TCTTCCTCAACCTCAGGCAGCAACACCATGATCAGAGCAGTTCGACCAGGGGAAACCTAC
ACTTATAAGTGGAACATCCTAGAATCTGATGAACCCACAGAAAATGATGCTCAGTGCTTA
ACAAGACCATACTACAGTAATGTGGACATCACAAGGGACCTTGCTTCTGGACTGATAGGG
CTTCTTCTAATTTGTAAGAGCAGATCCTTGGATAGACGAGGCATACAGAGGGCAGCAGAC
ATCGAGCAGCAGGCTGTGTTTGCCGTGTTTGACGAGAACAAGAGCTGGTACATTGAGGAC
AACATCTACAAGTTTTGTGAAAATCCTGAGAAAGTGAAACGTGATGACCCCAAGTTTTAT
GAGTCAAACATCATGAGTAATTTCACTCTTCCAGCTATTAACGGCTATGTGCCTGAGAGT
ATACCCATACTAGGGTTCTGCTTTGATGACACTGTCCAGTGGCACTTCTGCAGTGTGGGA
ACCCAGAATGACATTTTGACCATTCACTTCACTGGGCACTCATTCATCTATGGAAAGAGG
CACGAGGACACCTTGACCCTTTTCCCCATGCAGGGGGAATCCGTGACTGTCACAATGGAT
AATGTTGGAACTTGGATGTTAACCACCATGAATTCCAATCCAAGAAGCAAAAAACTACGG
CTGAGGTTCAGGGATGCTAAGTGTATCCGGAATGATGATGATGACTCCTATGAGATTATA
TATGAACCTTCAGGATCTACAGCCATGACTACAAAGAAAATTCATGATTCTTCAGAAATC
GAAGATGAAAATGATGCTGACTCTGATTACCAGGACGAACTGGCTTTAATACTAGGTCTT
AGGTCATTCAGAAATTCATCACTGAATCAGGAGAAAGATGAGCTCAATCTTACCGCCCTA
GCTCTGGAGAAAGACTCTGAATTCATTCCTCCGAGTGCCAACAGATCTCTTGATTCAAAT
TCTTCTTCCCGAAGTCATGTTAGCAGGCTTATTGCCAAAAACTTTGCAGAATCTCTGAAA
ACTCTTCTGCACCTGGAAGCCCCTGCAGCTGGTTCCCCCCTGGAACACGCTGGCTTAGAT
AAGAACTCAGCTCTCAACCCTCCCATGGCAGAGCATTCCAGCCCTTATTCTGAAGACCCT
AGAGAAGATCATCCACTCTCAGATGTCACAGGGGTAAGCCTACTTCCATTTGGCACAGGA
TTCAAAAATCGAAAACCTGCCAAACATCAAAGATTCCAGGTAGGAAGAGGCCAAGCAGCA
AAGCATAAGTTCTCCCAGACGCGATTCCCAGCACATAAAACCAGGACACGTTTAAGCCAA
GACAACTCTTCTTCTTCCAGAATGGGGCCCTGGGAGGACATTCCCAGTGATCTGTTACTC
TTACAACAAAAGGATCCATATAAGATTCTGAATGGAGAATGGCATTTGGTTTCTGAGAAA
GGCAGTTATGAAATAATCCAAGATGCTAATGAAAACAAGACTGTTAATAAGTTGCCAAAC
AGCCCCCAGAATGACTCAAGGACTTGGGGAGAAAACATCCCTTTCAAAAACAGTCATGGA
AAGCAGAGTGGCCACCCAACATTTTTGGTAACTAGACGTAAACCTCTACAAGACAGACAG
GATAGAAGAAATAGTAGATTGAAGGAAGGCCTTCCGTTAATTAGGACACGAAGAAAGAAA
AAGGAAGAGAAGCCTGCATACCATGTTCCTCTATCTCCAAGGAGTTTTCATCCTCTGAGA
GGAGAGGTCAATGCCTCATTTTCAGACAGAAGACATAATCATTCATTGTTACTCCATGCG
TCCAATGAAACATCTCTTTCCATAGACCTCAATCAGACATTCCCCTCTATGAATCTTAGC
CTTGCAGCCTCACTTCCTGACCATGACCAGACCTCACCAAATGACACCACCAGTCAGACT
AGCTCCCCTCCAGATCTTTATCCGACAGTGAGCCCAGAGGAACACTATCAAATATTCCCT
ATTCAAGACTCTGATCCAACACATTCTACTACAGCCCCCAGTAACAGATCTCCTGATCCA
ACACATTCTACTACAGCCCCCAGTAACAGATCTCCTCCCACACAGCCCAGCCAGATACCC
AACTATGACCTAAGAAACAGGGCCATCCCTACTGATGTGAGTCAAATTTTCCCTTCCTTG
GAACTCGAAGTCTGGCAGACAGCTACCTCTCTAGACCTCAGTCAACCATCCATCTCCCCA
GACCTTGGCCAGATGGCACTTTCCCCAGACCCCGGCCAGGAGTCTCTCTCTCCAGACCTT
GGCCAGACGTCCCTCTCTCCAGACCTCAGCCAGGAGTCTCTCTCCCCAGACCTTGGCCAG
ACAGCCCTTTCCCCAGACCCCAGCCAGGAGTCTCTCTCCCCAGACCTTGGCCAGACAGCC
CTTTCCCCAGACCCCAGCCAGGAGTCTCTCTCCCCAGACCTTGGCCAGACAGCCCTTTCC
CCAGACCCCGGCCAGGAGTCTCTCTCTCCAGACCTTGGCCAGACGTCCCTCTCTCCAGAC
CTCAGCCAGGAGTCTCTCTCCCCAGACCTTGGCCAGACAGCCCTTTCCCCAGACCCCAGC
CAGGAGTCTCTCTCCCCAGACCTTGGCCAGACAGCCCTTTCCCCAGACCCCAGCCAGGAG
TCTCTCTCTCCAGACCTTGGCCAGACGTCCCTCTCTCCAGACCTTGGCCAGGAGTCTCTC
TCCCCAGACCTTGGCCAGACAGCCCTTTCCCCAGACCCCAGCCAGGAGTCTCTCTCTCCA
GACCTTGGCCAGACGTCCCTCTCTCCAGACCTTGGCCAGGAGTCTCTCTCCCCAGACCTT
GGCCAGACAGCCCTTTCCCCAGACCTCAGCCAGGAGTCTCTCTCTCCAGATCTTGGCCAG
ACACCCCTCTCTCCAGACCTCAGCCTGGAGTCTCTTTCTCCAGACCTCAGCCAGCTTGAT
CTCAAGCAGACATCACCTCCTCTAGATCTTAATCAGACATCCCACACTTCTGAATCAAGT
CAGTCATTGCCTCTTCCAGAATTTGGTCAGACTTTCCCTAATGCAGATATTGGTCAGATG
CCATCTCCTCCACCAGACTCTACACTAAATAACACTTTTATACCAGAAGAATTTAATCCG
CTGGTTGTAGTAGGCCTCAGTAGAGATGATGGAGATTATATTGAAATTATTCCAAGGCAG
AAGGAAGAGAGCAGTGAAGAAGACTATGGTGAATTTGAGTTTGTAGCCTATAATGACCCT
TACCAAACTGATCTTAGGACAGATATCAACTCCTCCAGAAATCCTGACAACATTGCAGCA
TGGTACCTCCGCAGCAACACTGGAAACAGAAAATATTATTACATTGCAGCTGAAGAAATA
TCCTGGGATTATTCAAAATTTGTGCAAAGTGATGACGTTGACTATGTTCCAGAGGACACC
GTATACAAGAAAGTAGTTTTCCGAAAGTACCTTGATAGCACTTTTACCAAACTTGATCCT
CAGGGGGAGTATGAAGAGCATCTTGGCATACTTGGTCCAGTCATTAGAGCTGAAGTGGAT
GATGTTATCCAAGTTCGTTTTAAAAATTTAGCATCCAGACCATATTCTCTTCATGCCCAT
GGGCTTTCCTATGAAAAATCATCAGAAGGAAAGACTTATGAAGATGACTCTCCTGAATGG
TTTAAGGAGGACAATGCTATTCAGCCCAATAAAACTTACACCTATGTATGGCACGCCACT
ACGCGATCCGGGCCAGAAAACCCTGGATCTGCCTGTCGGGCTTGGGCCTACTACTCAGCA
GTGAACCCAGAAAAAGACATCCATTCAGGCTTGATAGGGCCTCTTCTGATCTGCCGAAAA
GGGACACTTGATAAGGAGACCAACATGCCTGTGGACATGAGAGAATTTGTCCTGCTTTTT
ATGGTCTTTGATGAAAAGAAGAGCTGGTATTATGACAAGAAGCCCACAAGGTCTTGGAGA
CGTGCATCCTCAGAAGTAAAAAACTCCCATGAGTTTCATGCCATCAATGGGATGATCTAC
AACTTGCCTGGCTTGAGAATGTACGAGCAAGAGTGGGTGAGGTTGCACCTGCTGAACTTA
GGCGGCTCCCGAGACATTCACGTGGTTCACTTTCATGGCCAGACCTTGCTAGAAAACGGC
ACTCAACAGCACCAGTTAGGGGTCTGGCCCCTTCTGCCTGGTTCATTTAAAACTCTTGAA
ATGAAGGCATCAAAACCTGGCTGGTGGCTCCTAGACACGGAAGTTGGAGAAATTCAGAGA
GCAGGGATGCAGACACCATTTCTCATTGTAGACAGAGAATGTAAGATGCCAATGGGACTA
AGCACTGGCCTGATAGCTGACTCACAGATCCAGGCTTCTGAGTTTTGGGGTTATTGGGAA
CCCAAATTAGCAAGGTTAAACAATGGTGGATCATACAATGCTTGGATTGCAGAAAAACTT
TCAACGGAATTTAACCCTGAACCTTGGATCCAGGTAGACATGCAAAAGGAAGTCCTGCTC
ACGGGGATCCAGACCCAGGGCGCCAAACACTACCTGAAGCCCTACTACACCACCGAGTTC
TGTGTGGCTTACAGCTTGGATCGGAAAAACTGGCGTATCTTCAAAGGGAACAGCACAAGG
AATGTGATGTATTTTGGTGGCAATTCAGATGCTTCTACAATAAAAGAGAATCAGATTGAC
CCACCTGTTGTGGCTAGATACATTAGGATCTCTCCAACTGGATCCTATAACAAACCTGCC
CTTCGATTGGAGCTGCAAGGTTGTGAGGTTAATGGATGCTCCACACCGCTGGGTATGGAA
AGTGGAAAGATAGAAAACAAGCAAATCACCGCTTCCTCGTTTAAAAAGTCTTGGTGGGGA
AATTACTGGGAACCCTTCCTTGCACGTCTTAATGCCCAGGGCCGTGTAAATGCCTGGCAA
GCTAAGGCAAACAACAACAATCAGTGGTTACAAATTGATCTGCTCAAAATCAAGAAGATA
ACTGCGATTGTAACACAAGGATGCAAGTCTCTGTCCTCTGAAATGTATGTGAAGAGCTAC
ACCATCCACTACAGTGACCAGGGAACGGACTGGAAACCTTACAGGGAGAAATCCTCAATG
GTGGACAAGATTTTCGAAGGAAATAATAATGTCAGAGGACATGTGAAGAACTTTTTCAAC
CCACCAATCATCTCCAGGTTTATACGCATCATTCCTAAAACATGGAATCAGAGTATTGCA
CTTCGCTTGGAACTCTTTGGCTGTGATATGTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 2211 |
| Molecular Weight
| 248983.0 |
| Theoretical pI
| 5.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 324-344
- 390-410
- 471-491
- 513-533
- 561-581
- 681-701
- 734-754
- 851-871
|
| Protein Sequence
|
>Coagulation factor V
MFLACPGFWVLVVLGSSWAGWGNLGAEAAKLRQFYVAAQSIRWNYRPESTHLSSKPFETS
FKKIVYREYEAYFQKEKPQSRTSGLLGPTLYAEVGDIMKVHFKNKAHKPLSIHAQGIKYS
KFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWIISEHSGPTHDDPPCLTHIYYSYVNLVE
DFNSGLIGPLLICKKGTLTEDGTQKMFEKQHVLMFAVFDESKSWNQTSSLMYTVNGYVNG
TMPDITVCAHDHISWHLIGMSSGPELFSIHFNGQVLEQNHHKISAITLVSATSTTANMTV
SPEGRWTIASLIPRHFQAGMQAYIDIKNCAKKTRNPKKLTRDQRRHIKRWEYFIAAEEVI
WDYAPIIPANMDKKYRSLHLDNFSNRIGKHYKKVVYKQYQDDSFTKRLEDPSSEGDGILG
PIIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYDNEVNSSSTSGSNTMIRAVRPGETY
TYKWNILESDEPTENDAQCLTRPYYSNVDITRDLASGLIGLLLICKSRSLDRRGIQRAAD
IEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSNFTLPAINGYVPES
IPILGFCFDDTVQWHFCSVGTQNDILTIHFTGHSFIYGKRHEDTLTLFPMQGESVTVTMD
NVGTWMLTTMNSNPRSKKLRLRFRDAKCIRNDDDDSYEIIYEPSGSTAMTTKKIHDSSEI
EDENDADSDYQDELALILGLRSFRNSSLNQEKDELNLTALALEKDSEFIPPSANRSLDSN
SSSRSHVSRLIAKNFAESLKTLLHLEAPAAGSPLEHAGLDKNSALNPPMAEHSSPYSEDP
REDHPLSDVTGVSLLPFGTGFKNRKPAKHQRFQVGRGQAAKHKFSQTRFPAHKTRTRLSQ
DNSSSSRMGPWEDIPSDLLLLQQKDPYKILNGEWHLVSEKGSYEIIQDANENKTVNKLPN
SPQNDSRTWGENIPFKNSHGKQSGHPTFLVTRRKPLQDRQDRRNSRLKEGLPLIRTRRKK
KEEKPAYHVPLSPRSFHPLRGEVNASFSDRRHNHSLLLHASNETSLSIDLNQTFPSMNLS
LAASLPDHDQTSPNDTTSQTSSPPDLYPTVSPEEHYQIFPIQDSDPTHSTTAPSNRSPDP
THSTTAPSNRSPPTQPSQIPNYDLRNRAIPTDVSQIFPSLELEVWQTATSLDLSQPSISP
DLGQMALSPDPGQESLSPDLGQTSLSPDLSQESLSPDLGQTALSPDPSQESLSPDLGQTA
LSPDPSQESLSPDLGQTALSPDPGQESLSPDLGQTSLSPDLSQESLSPDLGQTALSPDPS
QESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDLGQTALSPDPSQESLSP
DLGQTSLSPDLGQESLSPDLGQTALSPDLSQESLSPDLGQTPLSPDLSLESLSPDLSQLD
LKQTSPPLDLNQTSHTSESSQSLPLPEFGQTFPNADIGQMPSPPPDSTLNNTFIPEEFNP
LVVVGLSRDDGDYIEIIPRQKEESSEEDYGEFEFVAYNDPYQTDLRTDINSSRNPDNIAA
WYLRSNTGNRKYYYIAAEEISWDYSKFVQSDDVDYVPEDTVYKKVVFRKYLDSTFTKLDP
QGEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNKTYTYVWHATTRSGPENPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRK
GTLDKETNMPVDMREFVLLFMVFDEKKSWYYDKKPTRSWRRASSEVKNSHEFHAINGMIY
NLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLE
MKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTGLIADSQIQASEFWGYWE
PKLARLNNGGSYNAWIAEKLSTEFNPEPWIQVDMQKEVLLTGIQTQGAKHYLKPYYTTEF
CVAYSLDRKNWRIFKGNSTRNVMYFGGNSDASTIKENQIDPPVVARYIRISPTGSYNKPA
LRLELQGCEVNGCSTPLGMESGKIENKQITASSFKKSWWGNYWEPFLARLNAQGRVNAWQ
AKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTIHYSDQGTDWKPYREKSSM
VDKIFEGNNNVRGHVKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDMY
|
| External Links |
|---|
| GenBank ID Protein
| AAA30512.1 |
| UniProtKB/Swiss-Prot ID
| Q28107 |
| UniProtKB/Swiss-Prot Entry Name
| FA5_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M81440 |
| GeneCard ID
| F5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
