| Identification |
|---|
| BMDB Protein ID
| BMDBP01944 |
| Secondary Accession Numbers
| None |
| Name
| Glutaredoxin-2, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| GLRX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| GLRX2 |
| Gene Sequence
|
>474 bp
ATGTACTGGCGCCGCGCAGCGCTGGTGGGGACTCGGCTCATCCCGGTCAGGAGCAGCTCA
GCCGGCCGGCTTGAGGGGCCAGCGGGAATTTCGGGCTCCGGGATGGGGAACAGCACATCA
TCATCTTTGGGAAATGCAGCAACTGCTCCCGTGAATCAGATCCAAGAGACCATTTCTAAT
AATTGTGTGGTGATTTTCTCCAAGACATCCTGTTCTTACTGTACGATGGCAAAAAACCTT
TTCCATGACATGAATGTTAACTATAAAGTGGTGGAACTGGACATGCTTGAATATGGAAGT
CAGTTTCAAGATGCTCTTCACAAAATGACTGGCGAAAGAACCGTACCACGAATATTTGTC
AATGGAACTTTTATTGGAGGCGCAACTGACACTCATAGGCTTCACAAAGAAGGGAAATTG
CTTCCACTGGTTCACCAGTGTCATTTAAAAAACAGTAAGAGGGAAGAACTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 157 |
| Molecular Weight
| 17202.0 |
| Theoretical pI
| 9.28 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutaredoxin-2, mitochondrial
MYWRRAALVGTRLIPVRSSSAGRLEGPAGISGSGMGNSTSSSLGNAATAPVNQIQETISN
NCVVIFSKTSCSYCTMAKNLFHDMNVNYKVVELDMLEYGSQFQDALHKMTGERTVPRIFV
NGTFIGGATDTHRLHKEGKLLPLVHQCHLKNSKREEL
|
| External Links |
|---|
| GenBank ID Protein
| AAI09743.1 |
| UniProtKB/Swiss-Prot ID
| Q32L67 |
| UniProtKB/Swiss-Prot Entry Name
| GLRX2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109742 |
| GeneCard ID
| GLRX2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
