| Identification |
|---|
| BMDB Protein ID
| BMDBP01946 |
| Secondary Accession Numbers
| None |
| Name
| CDGSH iron-sulfur domain-containing protein 2 |
| Synonyms
|
Not Available
|
| Gene Name
| CISD2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 2 iron, 2 sulfur cluster binding |
| Specific Function
| Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| CISD2 |
| Gene Sequence
|
>408 bp
ATGGTGCTGGAGAGCGTGGCCCGCATCGTAAAGGTGCAGCTCCCCGCGTATCTGAAGCGG
CTTCCAGTGCCCGAGAGTATTACAGGGTTCGCCCGACTCACAGTTTCAGAATGGCTTCGG
TTGTTGCCTTTCCTTGGCGTACTCGCACTACTTGGCTACCTTGCAGTTCGTCCATTCCTC
CCGAAGAAAAAGCAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCC
AAAGTGGTGAATGAAATAAACATCGAAGATTTGTGCCTTACTAAAGCAGCTTATTGTAGG
TGTTGGCGTTCTAAGACGTTTCCTGCCTGTGATGGTTCACATAATAAACACAATGAATTG
ACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 135 |
| Molecular Weight
| 15278.0 |
| Theoretical pI
| 10.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CDGSH iron sulfur domain-containing protein 2
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFL
PKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNEL
TGDNVGPLILKKKEV
|
| External Links |
|---|
| GenBank ID Protein
| AAI22677.1 |
| UniProtKB/Swiss-Prot ID
| Q05B71 |
| UniProtKB/Swiss-Prot Entry Name
| CISD2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122676 |
| GeneCard ID
| CISD2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
