Identification
BMDB Protein ID BMDBP01947
Secondary Accession Numbers None
Name Adrenodoxin, mitochondrial
Synonyms Not Available
Gene Name FDX1
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus Not Available
SNPs FDX1
Gene Sequence Not Available
Protein Properties
Number of Residues 186
Molecular Weight 19756.0
Theoretical pI 5.3
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Adrenodoxin, mitochondrial
MAARLLRVASAALGDTAGRWRLLARPRAGAGGLRGSRGPGLGGGAVATRTLSVSGRAQSS
SEDKITVHFINRDGETLTTKGKIGDSLLDVVVQNNLDIDGFGACEGTLACSTCHLIFEQH
IFEKLEAITDEENDMLDLAYGLTDRSRLGCQICLTKAMDNMTVRVPDAVSDARESIDMGM
NSSKIE
GenBank ID Protein AAA30357.1
UniProtKB/Swiss-Prot ID P00257
UniProtKB/Swiss-Prot Entry Name ADX_BOVIN
PDB IDs
GenBank Gene ID M11746
GeneCard ID FDX1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available