1.0 2018-05-07 22:29:21 UTC 2020-05-20 21:07:32 UTC BMDBP01954 Enzyme SLC11A1 Inorganic ion transport and metabolism Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity). BMDB0000692 Iron 2 2q43-q44 >1647 bp ATGTCAGGTGACACGGGCCCCCCAAAGCAGGGAGGGACCAGATATGGCTCCATCTCCAGC CCACCCAGTCCAGAGCCACAGCAAGCACCTCCCGGAGGGACCTACCTAAGTGAGAAGATC CCCATTCCGGATACAGAATCGGGTACATTCAGCCTGAGGAAGCTGTGGGCCTTCACGGGG CCTGGATTCCTCATGAGCATCGCATTCCTGGACCCAGGAAACATTGAGTCGGATCTTCAG GCTGGGGCTGTGGCTGGATTCAAACTGCTCTGGGTGCTGCTGTGGGCCACAGTGTTGGGC TTGCTTTGCCAGCGACTGGCTGCCCGGCTGGGCGTGGTGACAGGCAAGGACTTGGGCGAG GTCTGCCATCTCTACTACCCTAAGGTGCCCCGCATTCTCCTCTGGCTGACCATCGAGCTA GCCATCGTGGGCTCAGACATGCAGGAAGTCATTGGCACAGCTATTGCATTCAGTCTGCTC TCCGCCGGACGAATCCCACTCTGGGGTGGTGTCCTCATCACCGTCGTGGACACTTTCTTC TTCCTCTTCCTCGATAACTACGGGTTGCGGAAGCTGGAAGCCTTTTTTGGATTTCTTATT ACCATAATGGCCTTGACCTTCGGCTATGAGTACGTGGTGGCTCAGCCTGCTCAGGGAGCA TTGCTTCAGGGCCTGTTCCTGCCCTCGTGCCCAGGCTGTGGCCAGCCCGAGCTGCTGCAA GCCGTGGGCATCATTGGCGCCATCATCATGCCCCACAACATCTACCTGCATTCCTCCCTG GTCAAGTCTCGAGAGGTAGACCGGTCCCGGCGGGCGGACATCCGAGAGGCCAACATGTAC TTCCTGATTGAAGCCACCATCGCCCTGTCTGTCTCCTTCCTCATCAACCTGTTTGTCATG GCTGTCTTTGGGCAAGCCTTCTACAAGCAAACCAACCAGGCTGCGTTCAACATCTGTGCC GACAGCAGCCTCCACGACTACGCGCCGATCTTTCCCAGGAACAACCTGACCGTGGCAGTG GACATTTACCAAGGAGGCGTGATCCTGGGCTGCCTCTTTGGTCCTCCAGCCCTGTACATC TGGGCCGTGGGTCTCCTGGCTGCTGGGCAGAGCTCCACCATGACCGGCACCTACGCGGGA CAGTTTGTGATGGAGGGCTTCCTGAAGCTGCGGTGGTCACGCTTCGCCCGAGTCCTGCTC ACTCGCTCCTGCGCCATCCTGCCCACTGTGCTCCTGGCTGTCTTCAGGGACTTGCGGGAC CTGTCAGGCCTCAACGACCTGCTCAATGTGCTGCAGAGCCTGCTGCTTCCCTTCGCTGTG CTGCCCATCCTCACCTTCACCAGCATGCCCGCCCTGATGCAGGAGTTTGCCAATGGCCTG GTGAGCAAAGTTATCACTTCCTCCATCATGGTGCTGGTCTGCGCCGTCAACCTTTACTTC GTGATCAGCTACTTGCCCAGCCTCCCCCACCCTGCCTACTTCAGCCTTGTAGCACTGCTG GCCGCAGCCTACCTGGGCCTCACCACTTACCTGGTCTGGACCTGTCTCATCACCCAGGGA GCCACTCTTCTGGCCCACAGTTCCCACCAACGCTTCCTGTATGGGCTTCCTGAAGAGGAT CAGGAGAAGGGGAGGACCTCGGGATGA 548 59568.0 6.85 56-73 83-102 140-160 165-184 194-214 238-256 285-304 347-366 398-415 427-447 464-485 494-513 None >Natural resistance-associated macrophage protein 1 MSGDTGPPKQGGTRYGSISSPPSPEPQQAPPGGTYLSEKIPIPDTESGTFSLRKLWAFTG PGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGE VCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITVVDTFF FLFLDNYGLRKLEAFFGFLITIMALTFGYEYVVAQPAQGALLQGLFLPSCPGCGQPELLQ AVGIIGAIIMPHNIYLHSSLVKSREVDRSRRADIREANMYFLIEATIALSVSFLINLFVM AVFGQAFYKQTNQAAFNICADSSLHDYAPIFPRNNLTVAVDIYQGGVILGCLFGPPALYI WAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLLAVFRDLRD LSGLNDLLNVLQSLLLPFAVLPILTFTSMPALMQEFANGLVSKVITSSIMVLVCAVNLYF VISYLPSLPHPAYFSLVALLAAAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEED QEKGRTSG AAA82582.1 Q27981 NRAM1_BOVIN U12862 SLC11A1