1.0 2018-05-07 22:29:24 UTC 2020-05-20 21:06:47 UTC BMDBP01967 Enzyme STRA6 Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid (By similarity). BMDB0000305 Vitamin A 21 >2007 bp ATGTCCACCCAGGCGGCAGGGAACCAGACCTCCTCCGGGGCCACTGACAGCGAGGATTCC TATGACAGCTGGTACATCGACGAGCCCCAGGGTGGCCAGGAGCTCCAGCCCGAGGGGCTG GTCCCCTCCTGCCAGCCCAATGTGCCACCCAGCCTCTACCACACCTGCCTGGCCGTGCTG TCGATCCTCGTGTTGTTTCTGCTGGCCATGCTGGTGAGGCGCCGCCAGCTCTGGCCCCGC TGTGGGCATGGCAGGCCCGGGCTGCCCAGCCCTGTGGATTTCTTGACTGGGGACAGGCCC CGGACCGTGCCTGCCGCTGTCTTCATGGTCCTCTTCAGCTCCCTGTGCCTGCTGCTCCCC ACCGAGGACCCGCTGCCTTTCCTGAGCCTCGCCTCACCACCCGGCCGAGATGGGGAAGCT GAGACTTCAAGAGGGCCTTGGAAGATACTGGCTCTGCTGTATTACCCTGCCCTCTACTAT CCGCTGGCTGCCTGTGCCACCGTCAGGCATGGAGCCGCCCACCTGCTCGGCAGCCTGCTG TCCTGGGCTCATCTGGGGGTCCAGGTCTGGCAAAGGGCAGAGTGTCCTGAGTCACCCAAG ATTTACAAGTACTACTCCCTGTTGGCCTCGCTGCCTCTCCTTCTGGGCCTCGGATTCCTG AGCCTTTGGTACCCAGTGCAGCTGGTGAGAAGCTTCGGTCACGGGGCAGCCACGGGTTCC AAGGGGCTGCAGAGCAGCTACTCTGAAGAATATCTGAGGACCCTCCTTTGCCAGAAGAAG CTGAAAAGCAGCTCCCACACCTGCAAGCGTGGCTTCGCATCCCAGGCCTGGATGTACTTC AGACACTCCGTCTACATTCCACAACGAGGATTCCGACTCCCCCTGAAGCTGGTGCTCTCA GTCACCCTGACAGGGACGGCCATCTACCAGGTGGCCCTGCTGCTGCTAGTGGGCGTGGTA CCCACCATCCAGAAGGTGAGGGCGGGGATCACCACGGACGTCTCCTACCTGCTGGCCGGC TTTGGGATCGTGCTCTCAGAGGACAGGCAGGAGGTGGTGGAGCTGGTGAAGCACCACCTG TGGGCTCTAGAAGTTTGCTACATCTCGGCCTTGGTGCTGTCTTGCTTGCTGACCTTCCTC ATGCTGGTCCACTCGCTGGTGACACACAGGACCAACCTGCGAGCTCTGCACCGAGGGGGC GCCCTGGACATAGGCCCCCTGACCCAGAGCCCCCGCCCCTCCCGCCAGGCCATATTCTGC TGGATGAGCTTCACCGCCTACCAGACTGCTTTTACCTGCCTTGGACTCCTGGTACAGCAG ATCCTCTTCTTCCTGGGGACCTTGACCCTGGCCTTCCTGGTGTTCATGCCCATGCTTCAC GGCAGGAACCTCCTGCTCCTCCATTACCTGAAGTCCTCGTGGCCCTTCTGGCTGACCTTG GCCCTGGCTGTGACCCTGCAGAACGCAGCGGCCCACTGGGCCTTCCTGGACACTCACCAT GGACGCCCGGGGCTGACCAACCGAAGAGCACTCTATGCAGCCACCTTCCTTCTCTTCCCC GTCAACGTGCTGGTGGGCACCATGGTGGCCGCCTGGAGAGTGCTCCTCTCTGCCCTCTAC AATGCCGTCCACCTTGGCCGGATGGACCTCAGCCTGCTGCCGCTTAGAGCTGCCACTCTT GACCCCGGCTACCACACATACTGCAACTTCTTGAGGATGGAGGCCAGCCAGTCACACCCA GCTGCGACGGCCTTCTGTGCCCTGCTTCTGCGGACTCAGAGGCCCAAGCCCCGCGCGACC CCCCAGGATGGCCTCAGACTGGGGGAGGAAGAGGAAGGGATTCAGCTGCTACAGACCAAG GACCTGGTGGCCAAGGGAGCGGGGCCCAGGGCCCGCCAAGGCAGGGCTCGCTGGGGTCTG GCGTACACGCTGCTGCACAACCCAGCTCTGCAGGCCTTCCGGAAGACAGCCCTGCCAGGT GCCCGGCCCAACGGTGCCCAGCCCTGA 668 73762.0 9.67 52-72 102-122 146-166 170-190 207-227 297-317 369-389 424-444 475-495 None >Stimulated by retinoic acid gene 6 protein homolog MSTQAAGNQTSSGATDSEDSYDSWYIDEPQGGQELQPEGLVPSCQPNVPPSLYHTCLAVL SILVLFLLAMLVRRRQLWPRCGHGRPGLPSPVDFLTGDRPRTVPAAVFMVLFSSLCLLLP TEDPLPFLSLASPPGRDGEAETSRGPWKILALLYYPALYYPLAACATVRHGAAHLLGSLL SWAHLGVQVWQRAECPESPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFGHGAATGS KGLQSSYSEEYLRTLLCQKKLKSSSHTCKRGFASQAWMYFRHSVYIPQRGFRLPLKLVLS VTLTGTAIYQVALLLLVGVVPTIQKVRAGITTDVSYLLAGFGIVLSEDRQEVVELVKHHL WALEVCYISALVLSCLLTFLMLVHSLVTHRTNLRALHRGGALDIGPLTQSPRPSRQAIFC WMSFTAYQTAFTCLGLLVQQILFFLGTLTLAFLVFMPMLHGRNLLLLHYLKSSWPFWLTL ALAVTLQNAAAHWAFLDTHHGRPGLTNRRALYAATFLLFPVNVLVGTMVAAWRVLLSALY NAVHLGRMDLSLLPLRAATLDPGYHTYCNFLRMEASQSHPAATAFCALLLRTQRPKPRAT PQDGLRLGEEEEGIQLLQTKDLVAKGAGPRARQGRARWGLAYTLLHNPALQAFRKTALPG ARPNGAQP ABG81428.1 Q0V8E7 STRA6_BOVIN BT026272 STRA6