1.0 2018-05-07 22:29:29 UTC 2020-05-20 21:10:36 UTC BMDBP01983 Enzyme MMACHC Involved in cobalamin binding Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives. Adenosylcobalamin biosynthesis Cofactor biosynthesis BMDB0000608 Cobalt BMDB0002174 Cobalamin 3 >843 bp ATGGAGCCGCTAGTCGCAGAGCTGAAGCAGAAGATTGAGGACACGTTGTGCCCTTTTGGC TTCGAAGTTTACCCCTTCCAGGTGGCATGGTACAATGCACTCCTGCCTCCAGCCTTCCAC CTACCCCTGCCAGGACCTACACTGGCCTTCCTGGTACTCAGCACACCTGCCATGTTTGAC CAGGCCCTCAAGCCCTTCCTGCAGAGCCACCACCTCCAACCACTGACTGACCCTGTGGAC CAGTGTGTGGCCTACCACCTGGGCCGAGTTAGAGAGAGCCTCCCAGAGCTGCAGATAGAA GTCATCGCTGACTACGAGGTACACCCCAACCGGCGCCCCAAGATCCTGGCCCAGACAGCA GCCCATGTAGCAGGGGCTGCTTACTACTATCAGCGACAGGATGTGGAGTCTGACCCTTGG GGGACCCAGCACATAGCAGGTGTGTGCATACATCCCAGGTTTGGGGGCTGGTTTGCCATC CGAGGGGTGGTGCTACTGCGAGGAACAGAGGTGCCGAATCTGCCACCCACAAAGCCCGTT GACTGTGTACCCACAAGAGCTGACCGCATCAGCCTGCTTGAACGCTTCAATTTCCATTGG CGTGACTGGACTTACCGGGATGCTGTGACACCTCAGGAGCGCTACTCAGAAGAGCAGAAG GCATACTTTTCCACTCCTCCTGCCCAACGCTTGGCCTTACTGGGCTTGCTTCAGCCCTCA GAGGAGCCTAGCTCTCCATCCCAAGAGCTTCACATCACTACACTCTTATCCAAGAAGCCT CAGAATCCCAGGAGAGGCTGGCTCAGTCCCACAGTTTCCCCACCTATATCCCCTGGACCC TGA 280 31633.0 6.85 19-39 None >Methylmalonic aciduria and homocystinuria type C homolog MEPLVAELKQKIEDTLCPFGFEVYPFQVAWYNALLPPAFHLPLPGPTLAFLVLSTPAMFD QALKPFLQSHHLQPLTDPVDQCVAYHLGRVRESLPELQIEVIADYEVHPNRRPKILAQTA AHVAGAAYYYQRQDVESDPWGTQHIAGVCIHPRFGGWFAIRGVVLLRGTEVPNLPPTKPV DCVPTRADRISLLERFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLLQPS EEPSSPSQELHITTLLSKKPQNPRRGWLSPTVSPPISPGP AAX09009.1 Q5E9C8 MMAC_BOVIN BT020992 MMACHC