| Identification |
|---|
| BMDB Protein ID
| BMDBP01989 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic AMP-dependent transcription factor ATF-1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein dimerization activity |
| Specific Function
| This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). |
| Pathways
|
- TNF/Stress Related Signaling
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| ATF1 |
| Gene Sequence
|
>813 bp
ATGGAAGATTCTCACAAGAGTAACACTTCAGAGACAGCACCTCAATCTGGTTCCACAGTT
CAGGCAGCTCATATTTCTCATATTGCTCAACAGGTATCATCTTTATCAGAGAGTGAGGAG
TCTCAGGACTCATCTGACAGCATAGGCTCCTCACAGAAAACCCACGGGATCCTAGCACGG
CGCCCATCTTACAGAAAGATTTTGAAAGACCTATCTTCTGAAGATATACGGGGCAGAAAA
GGAGACGGAGAAAACCCTGGAGTCTCTGCTGTCACTTCTATGTCTGTTCCAACTCCCATC
TATCAGACCAGCACCGGACAGTACATTGCCATTGCCCCAAATGGAGCCTTACAGCTGGCC
AGTCCAGGCACAGATGGAGTACAGGGCCTTCAGACATTAACCATGACAAATTCAGGCAGT
ACTCAGCAAGGTACAACAATTCTCCAGTACGCACAGACTTCTGATGGACAACAAATACTT
GTGCCCAGCAACCAGGTTGTTGTACAAACTGCGTCAGGAGATATGCAGACATATCAGATC
CGTACTACACCTTCAGCTACTTCACTACCACAGACTGTGGTGATGACATCTCCCGTGACC
CTTACATCTCAGACATCCAAGACAGATGACCCCCAACTGAAAAGAGAAATAAGGTTGATG
AAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTG
GAAAATCGAGTCGCAGTTCTGGAAAATCAAAACAAAACTCTAATAGAAGAGTTAAAAACT
TTGAAGGATCTTTATTCTAATAAAAGTGTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 270 |
| Molecular Weight
| 29261.0 |
| Theoretical pI
| 8.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cyclic AMP-dependent transcription factor ATF-1
MEDSHKSNTSETAPQSGSTVQAAHISHIAQQVSSLSESEESQDSSDSIGSSQKTHGILAR
RPSYRKILKDLSSEDIRGRKGDGENPGVSAVTSMSVPTPIYQTSTGQYIAIAPNGALQLA
SPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQI
RTTPSATSLPQTVVMTSPVTLTSQTSKTDDPQLKREIRLMKNREAARECRRKKKEYVKCL
ENRVAVLENQNKTLIEELKTLKDLYSNKSV
|
| External Links |
|---|
| GenBank ID Protein
| AAI23856.1 |
| UniProtKB/Swiss-Prot ID
| Q08DA8 |
| UniProtKB/Swiss-Prot Entry Name
| ATF1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123855 |
| GeneCard ID
| ATF1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
