| Identification |
|---|
| BMDB Protein ID
| BMDBP01991 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic nucleotide-gated olfactory channel |
| Synonyms
|
Not Available
|
| Gene Name
| CNGA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| CNGA2 |
| Gene Sequence
|
>1992 bp
ATGACAGAAAAAGCCAATGGCGTGAAGAGCTCCCCAGCCAATAACCACAACCACCATGCC
CCTCCTGCCATCAAGGCCAGTGGCAAAGATGACCACAGGGCCAGCAGCCGGCCACAGTCT
GCTGCTGCTGATGACACCTCCTCAGAGCTACAGCAACTGGCAGAGATGGATGCCCCCCAG
CAGAGGAGGGGTGGCTTCCGCAGGATTGCCCGCCTGGTGGGGGTCCTCAGAGAGTGGGCT
TACAGGAACTTCCGTGAGGAGGAGCCTAGACCTGACTCATTCCTTGAGCGTTTCCGGGGG
CCTGAGCTCCACACCGTGACAACACAACAAGGAGACGGCAAAGGCGACAAGGACGGCGAG
GGCAAGGGCACCAAGAAGAAGTTTGAACTCTTTGTCTTGGACCCAGCCGGGGACTGGTAC
TACCGCTGGCTTTTTCTCATTGCCTTGCCCGTCCTCTACAACTGGTGCCTATTGGTGGCC
AGAGCCTGCTTCAGTGACCTGCAGAAAGGCTACTACATAGTGTGGCTGGTGCTGGATTAC
GTCTCAGATGTGGTCTACATCGCAGACCTCTTCATCCGACTGCGCACAGGTTTCTTGGAG
CAGGGGCTACTGGTGAAAGACACCAAGAAGTTGCGGGACAACTACATCCACACCATGCAG
TTTAAGCTGGATGTGGCCTCCATCATCCCTACAGACCTGATCTATTTTGCTGTGGGGATC
CATAACCCTGAGGTGCGCTTCAACCGCCTGCTACACTTTGCCCGCATGTTTGAGTTCTTT
GACCGCACTGAGACACGCACCAGCTACCCCAACATCTTCCGAATAAGCAACCTGATCCTC
TACATCTTGATCATCATTCACTGGAATGCCTGCATCTACTATGCCATCTCCAAGTCCATC
GGCTTTGGGGTAGACACCTGGGTTTACCCCAACATCACTGACCCTGAGTATGGCTACCTG
TCTAGGGAGTACATCTATTGCCTTTACTGGTCTACACTGACCCTCACCACCATTGGGGAG
ACACCACCCCCTGTAAAGGATGAGGAGTACCTGTTTGTCATCTTTGACTTCCTGATTGGT
GTCCTCATCTTTGCCACCATCGTGGGAAATGTGGGCTCCATGATCTCCAACATGAATGCC
ACCCGGGCTGAGTTCCAGGCCAAGATTGATGCTGTCAAACATTATATGCAGTTCCGAAAG
GTCAGCAAGGAGATGGAAGCCAAGGTCATTAGGTGGTTTGACTACTTGTGGACCAATAAG
AAGAGTGTAGATGAGCGAGAAGTCCTCAAAAACCTGCCAGCAAAGCTCAGGGCTGAGATA
GCCATCAACGTCCACCTGTCCACACTCAAGAAAGTGCGCATCTTTCAGGACTGTGAGGCT
GGCCTGCTGGTGGAACTGGTATTAAAGCTCCGGCCTCAGGTCTTTAGCCCTGGGGACTAC
ATTTGCCGCAAGGGGGATATTGGGAAGGAGATGTACATAATCAAGGAGGGAAAATTGGCA
GTGGTGGCTGATGACGGTGTCACTCAGTATGCCCTGCTCTCGGCTGGGAGTTGCTTTGGA
GAGATCAGTATCCTTAATATTAAGGGCAGCAAAATGGGCAATCGGCGCACAGCCAACATC
CGCAGTCTTGGCTACTCTGATCTGTTCTGCTTGTCCAAGGATGATCTTATGGAAGCTGTG
ACTGAGTACCCTGATGCCAAGAGGGTCTTGGAGGAGAGAGGCCGGGAGATTCTGATGAAG
GAGGGCTTGTTGGATGAGAATGAGGTGGCAGCCAGCATGGAGGTAGATGTGCAGGAAAAG
CTAGAACAGCTGGAGACCAACATGGACACCTTGTACACTCGTTTTGCCCGCCTGCTGGCC
GAGTACACGGGAGCCCAGCAGAAGCTCAAGCAGCGCATCACAGTTTTGGAAACGAAGATG
AAGCAGAATAATGAGGATGACTCCCTGTCAGATGGGATGAACAGCCCAGAGCCACCTGCC
GAGAAGCCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 663 |
| Molecular Weight
| 76014.0 |
| Theoretical pI
| 6.74 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 141-160
- 174-192
- 217-236
- 275-297
- 350-369
- 454-474
|
| Protein Sequence
|
>Cyclic nucleotide-gated olfactory channel
MTEKANGVKSSPANNHNHHAPPAIKASGKDDHRASSRPQSAAADDTSSELQQLAEMDAPQ
QRRGGFRRIARLVGVLREWAYRNFREEEPRPDSFLERFRGPELHTVTTQQGDGKGDKDGE
GKGTKKKFELFVLDPAGDWYYRWLFLIALPVLYNWCLLVARACFSDLQKGYYIVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTMQFKLDVASIIPTDLIYFAVGI
HNPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLILYILIIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLSREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKEMEAKVIRWFDYLWTNK
KSVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKRVLEERGREILMKEGLLDENEVAASMEVDVQEK
LEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNNEDDSLSDGMNSPEPPA
EKP
|
| External Links |
|---|
| GenBank ID Protein
| CAA38754.1 |
| UniProtKB/Swiss-Prot ID
| Q03041 |
| UniProtKB/Swiss-Prot Entry Name
| CNGA2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X55010 |
| GeneCard ID
| CNGA2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
