| Identification |
|---|
| BMDB Protein ID
| BMDBP01998 |
| Secondary Accession Numbers
| None |
| Name
| CREB-regulated transcription coactivator 2 |
| Synonyms
|
Not Available
|
| Gene Name
| CRTC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| CRTC2 |
| Gene Sequence
|
>2082 bp
ATGGCGACGTCGGGAGCGAATGGGCCCGGTTCGGCCACGGCCTCAGCTTCCAATCCGCGT
AAGTTTAGTGAGAAGATCGCGCTGCAGAAGCAGCGTCAGGCCGAGGAGACGGCGGCCTTC
GAGGAGGTGATGATGGACATCGGCTCCACCCGGTTACAGGCCCAAAAACTTCGGCTGGCA
TACACAAGGAGCTCCCACTATGGTGGCTCTCTGCCCAATGTGAACCAGATTGGCTGTGGC
CTAGCCGAGTTCCAGAGCCCCCTCCACTCCCCTCTGGATTCATCTCGGAGCACTCGACAT
CACGGGCTGGTGGAACGGGTGCAGCGAGATCCCCGAAGAATGGTGTCCCCGCTTCGCCGC
TACGCCCGCCACATTGACAGCTCTCCCTATAGTCCTGCCTATTTATCTCCTCCCCCGGAG
TCCAGCTGGCGGAGGACAATGCCCTGGGGCAGTTTCCCTGCAGAGAAGGGACAGTTGTTT
CGACTACCATCTGCACTTAACAGGACAAGCTCTGACTCTGCCCTTCACACAAGCGTGATG
AACCCCAGCCCTCAGGACACGTATCCAAGCCCTGCAGCCCCCAGCGTCCTGCCGAGCCGC
CGTGGAGGTTGTCTGGACGGCGAGACGGACTCCAAAGTCCCTGCTATTGAGGAGAACTTG
CTAGATGATAAGCACTTGTTGAAACCATGGGATGCTAAGAAGCTGTCCTCGTCCTCCTCC
CGACCTCGGTCCTGTGAAGTCCCTGGAATTAACATCTTCCCGTCTCCTGACCAGCCTGCC
ACTGTGCCTGTCCTCCCACCTGCCATGAACACGGGAGGCTCCCTACCTGACCTCACCAAC
CTGCACTTTCCCCCACCGCTACCCACCCCCCTGGACCCAGAGGAGACAGCCTATCCCAGC
CTGAGTGGGGGCAGCAGTACCTCCAATTTGACCCACACCATGACCCACCTGGGCATCAGC
GGGGGCCTGGCCCTGGGCCCGGGCTATGATGCGCCAGGACTTCATTCACCTCTCAGCCAC
CCATCCTTTCAGTCCTCCCTAAGCAATCCCAACCTCCAGGCTTCCCTGAGCAGTCCTCAG
CCCCAGCTCCAGGGCTCCCACAGTCACCCCTCACTGCCTGCTTCCTCCTTGGCTCGCCAC
GCACTGCCCACCACCTCCCTGGGCCACCCCTCGCTCAGTGCCCCGGCCCTCTCCTCCTCC
TCTTCCTCCTCTTCCGCTTCCTCTCCGGTGCTGGGGGCCCCCGCTTACCCAGCTTCTGCC
CCTGGGGCCTCCCCCCGCCACCGCCGTGTGCCCCTCAGTCCCCTGAGTTTGCCCGCGGGC
CCAGCCGACGCCAGAAGGTCCCAACAGCAACTGCCCAAACAGTTTTCGCCAACAATGTCA
CCCACCTTGTCTTCCATCACTCAGGGCGTCGCCCTGGATACCAGTAAGCTGCCCACCGAC
CAGCGGCTGCCTCCATACCCATACAGCCCCCCAAGTCTGGTTCTGCCCACCCAGCAACCC
ACCCCAAAGCCTCTGCAGCAGCCAGGGCTGCCCTCTCAGGCCTGCTCAGTGCAGCCCTCA
GGGGGCCAGCCCCCAGGCAGGCAGCTGCAGTATGGGACACTGTACCCGCCCGGACCCAGT
GGGCACGGGCAACAGTCTTACCACCGGTCGATGAGTGACTTCAGCCTGGGGAACCTGGAG
CAGTTCAACATGGAGAACCCATCGACCAGCCTGGCGCTGGATCCCCCTGGCTTTTCCGAA
GGGCCTGGCTTCTTAGGGGGTGAGGGACCAGTGAGTGGCCCCCAGGACCCTCACGCCCTC
AACCACCAGAACGTAACCCACTGTTCCCGCCACGGCTCAGGGCCTAACGTCATCCTCACA
GGAGACGCCTCCCCAGGCTTCTCCAAGGAGATTGCAGCGGCCCTGGCCGGAGTGCCGGGC
TTCGAGGTGTCAGCAGCTGGGCTGGGGCTGGGGCTGGGGCTGGAGGAGGAGCTGCGCATG
GAGCCACTGGGCCTGGAGGGGCTCAGCATGCTGAGTGACCCCTGCGCCCTGCTGCCTGAT
CCGGCTGTGGAGGACTCGTTCCGCAGTGACCGGCTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 693 |
| Molecular Weight
| 72818.0 |
| Theoretical pI
| 7.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>CREB-regulated transcription coactivator 2
MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLA
YTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRR
YARHIDSSPYSPAYLSPPPESSWRRTMPWGSFPAEKGQLFRLPSALNRTSSDSALHTSVM
NPSPQDTYPSPAAPSVLPSRRGGCLDGETDSKVPAIEENLLDDKHLLKPWDAKKLSSSSS
RPRSCEVPGINIFPSPDQPATVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPS
LSGGSSTSNLTHTMTHLGISGGLALGPGYDAPGLHSPLSHPSFQSSLSNPNLQASLSSPQ
PQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASA
PGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTD
QRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPS
GHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHAL
NHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRM
EPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI23455.1 |
| UniProtKB/Swiss-Prot ID
| Q08E26 |
| UniProtKB/Swiss-Prot Entry Name
| CRTC2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123454 |
| GeneCard ID
| CRTC2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
